Table of Contents
iCRT14 30μM R08 exp492
Mechanism of Action
Inhibits β-catenin-dependent transcription, may alter interaction of β-catenin with TCF4
- Class / Subclass 1: Gene Regulation / Transcription Inhibitor
Technical Notes
Protein References
- PubChem Name: CID 5967294
- Synonyms: N/A
- CAS #: 677331-12-3
- PubChem CID: 5967294
- IUPAC: (5Z)-5-[(2,5-dimethyl-1-pyridin-3-ylpyrrol-3-yl)methylidene]-3-phenyl-1,3-thiazolidine-2,4-dione
- INCHI Name: InChI=1S/C21H17N3O2S/c1-14-11-16(15(2)23(14)18-9-6-10-22-13-18)12-19-20(25)24(21(26)27-19)17-7-4-3-5-8-17/h3-13H,1-2H3/b19-12-
- INCHI Key: NCSHZXNGQYSKLR-UNOMPAQXSA-N
- Molecular Weight: 375.4
- Canonical SMILES: CC1=CC(=C(N1C2=CN=CC=C2)C)C=C3C(=O)N(C(=O)S3)C4=CC=CC=C4
- Isomeric SMILES: CC1=CC(=C(N1C2=CN=CC=C2)C)/C=C\\3/C(=O)N(C(=O)S3)C4=CC=CC=C4
- Molecular Formula: C21H17N3O2S
Protein Supplier
- Supplier Name: Med Chem Express
- Catalog #: HY-16665
- Lot #: 23429
Protein Characterization
- HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C21H17N3O2S 376.11142; found 376.11235
Dose Response Curve
- Platform ID: iCRT14
- Min: -11.0010; Max: 69.6272
| IC | Concentration (µM) |
|---|---|
| IC10 | 4.0980 |
| IC20 | 8.5500 |
| IC30 | 13.9400 |
| IC40 | 20.8100 |
| IC50 | 30.0600 |
| IC60 | 43.4100 |
| IC70 | 64.8100 |
| IC80 | N/A |
| IC90 | N/A |
Screen Summary
- Round: 08
- Dose: 30µM
- Days of incubation: 8
- Doublings: 1.2
- Numbers of reads: 17101968
Screen Results
| Sensitive/Resistant hits (FDR<0.05) | CRANKS | Score Plot | Top 30 Genes | Screen Similarity | Top 30 Sensitive GO terms | Top 30 Resistant GO terms |
|---|---|---|---|---|---|---|
| 12/56 | Scores |
iCRT14 30μM R08 exp492
Oligomycin-A 2μM R00 exp25 vs iCRT14 30μM R08 exp492
Senexin-A 25μM R07 exp400 vs iCRT14 30μM R08 exp492
UM0129480 7μM R02 exp85 vs iCRT14 30μM R08 exp492
Thimerosal 0.85μM R08 exp529 vs iCRT14 30μM R08 exp492
Hippuristanol 0.12μM R08 exp488 vs iCRT14 30μM R08 exp492
Cannabidiol 20μM R08 exp466 vs iCRT14 30μM R08 exp492
LLY-283 2.6μM R06 exp290 vs iCRT14 30μM R08 exp492
Trimetrexate 0.03μM R08 exp535 vs iCRT14 30μM R08 exp492
Rotenone 0.07μM R08 exp431 vs iCRT14 30μM R08 exp492
Calcium Ionophore 0.4μM R07 exp342 vs iCRT14 30μM R08 exp492
AICAR 240μM R03 exp116 vs iCRT14 30μM R08 exp492
Lead acetate 2000μM R08 exp497 vs iCRT14 30μM R08 exp492
Lead acetate 2000μM R08 exp498 no dilution day6 vs iCRT14 30μM R08 exp492
Amiloride 100μM R08 exp447 vs iCRT14 30μM R08 exp492
Mubritinib 0.2μM R02 exp65 vs iCRT14 30μM R08 exp492
FK-506 30μM R07 exp359 vs iCRT14 30μM R08 exp492
Aphidicolin 0.4μM R08 exp440 vs iCRT14 30μM R08 exp492
Phenformin 20μM R05 exp212 vs iCRT14 30μM R08 exp492
ONC212 0.15μM R08 exp513 vs iCRT14 30μM R08 exp492
Dorsomorphin 5μM R07 exp357 vs iCRT14 30μM R08 exp492
Ethanol 0.01 R05 exp234 vs iCRT14 30μM R08 exp492
∆-9-Tetrahydrocannabinol 30μM R08 exp445 vs iCRT14 30μM R08 exp492
QNZ 0.01μM R05 exp241 vs iCRT14 30μM R08 exp492
Chloroquine 32μM R08 exp470 vs iCRT14 30μM R08 exp492
Hydroxyurea 100μM R07 exp329 vs iCRT14 30μM R08 exp492
QNZ 0.01μM R08 exp439 vs iCRT14 30μM R08 exp492
UM0125461 0.74μM R02 exp84 vs iCRT14 30μM R08 exp492
CR131-b 0.005μM R08 exp474 vs iCRT14 30μM R08 exp492
JQ1 0.8μM R08 exp435 vs iCRT14 30μM R08 exp492
Torin1 0.08μM R02 exp82 vs iCRT14 30μM R08 exp492
Milciclib 2μM R08 exp502 vs iCRT14 30μM R08 exp492
Thapsigargin 0.005μM R07 exp407 vs iCRT14 30μM R08 exp492
Hippuristanol 0.12μM R08 exp489 no dilution day6 vs iCRT14 30μM R08 exp492
GSK-J4 1.5μM R08 exp441 vs iCRT14 30μM R08 exp492
