BRD1

Gene Information

Official Symbol: BRD1
Official Name: bromodomain containing 1
Aliases and Previous Symbols: N/A
Entrez ID: 23774
UniProt: O95696
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. {ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:21880731}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
BML-284 0.09μM R08 exp460	-3.96
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179	-3.61
Demecolcine 0.03μM R05 exp228	-3.41
Vemurafenib 6.6μM R08 exp434	-3.33
Azithromycin 100μM R08 exp452	-3.29
2-Methoxyestradiol 0.55 to 0.75μM on day4 R07 exp311	-3.24
Mdivi-1 15μM R05 exp217	-3.21
Milciclib 2μM R08 exp502	-3.2
GSK626616 14μM R08 exp485	-3.1
UMK57 1μM R01 exp59	-3.08
Quercetin 20μM R08 exp517	-3.07
2-Methoxyestradiol 0.55μM R07 exp310	-3
FTY720 3μM R08 exp483	-2.98
Vemurafenib 6.6μM R02 exp89	-2.8
Vinblastine 0.002μM R01 exp60	-2.74
LLY-283 2.6μM R06 exp290	-2.71
Chloroquine 32μM R08 exp470	-2.69
MK2206 4μM R08 exp504	-2.65
Nicotine 3000μM R08 exp510	-2.65
Colchicine 0.009μM R05 exp215	-2.59
Deferoxamine 11μM R07 exp350	-2.53
A-395 10μM R05 exp218	-2.51
Apcin 50 to 100μM on day4 R04 exp176	-2.44
BI-D1870 2μM R04 exp162	-2.43
UMK57 0.6μM R03 exp107	-2.37
GSK591 2.6μM R03 exp128	-2.33
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312	-2.31
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	-2.28
Bafilomycin-A1 0.009μM R08 exp454	-2.28
Clomiphene 4.4μM R02 exp68	-2.2
S-trityl-L-cysteine 0.5μM R05 exp243	-2.16
UNC1999 2μM R03 exp155	-2.16
BS-181 20μM R08 exp461	-2.12
Chlorpromazine 10μM R07 exp344	-2.03
LJH685 50μM R08 exp433	-1.99
BVD-523 15μM R02 exp67	-1.96
CI-1040 9.5μM R08 exp472	-1.92
Rucaparib 6.5μM R08 exp520	-1.92
HMS-I1 1μM R01 exp46	-1.9
Q15 2.7μM R02 exp79	-1.89
L-74142 5μM R03 exp131	-1.85
CCT251545 20μM R07 exp326	-1.84
BI-D1870 3.15μM R02 exp66	-1.82
Artemisinin 50μM R08 exp450	-1.81
Bortezomib 0.05μM R00 exp7	-1.78
TRAIL 50ng/ml R00 exp36	-1.78
AICAR 240μM R03 exp116	-1.76
Ribavirin 10 to 15μM on day4 R04 exp160	-1.76
Apcin 25μM plus proTAME 2μM R04 exp177	-1.74
Cerivastatin 0.15μM R05 exp226	-1.72
NN-Dimethylsphingosine 2.5μM R08 exp508	-1.72
Hydroxychloroquine 30μM R08 exp490	-1.71
KU-0063794 3.8μM R02 exp71	-1.71
Thioridazine 5μM R08 exp530	-1.71
Selumetinib 20μM R02 exp81	-1.7
SB203580 25μM R03 exp149	-1.7
ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319	1.76
Salubrinal 20μM R07 exp399	1.79
5-Azacytidine 2μM R07 exp330	1.91
LY2090314 0.003μM R08 exp500 no dilution day6	2
Alda-1 10μM R06 exp262	2.02
Resminostat 0.5μM R07 exp393	2.02
Trichostatin-A 0.06μM R07 exp415	2.07
Lead acetate 2000μM R08 exp497	2.1
Hippuristanol 0.12μM R08 exp489 no dilution day6	2.12
THZ531 0.11 to 0.125μM on day4 R07 exp410	2.17
Tubacin 1.6μM R07 exp416	2.26
Hypoxia 5%O2 R04 exp191	2.29
Zebularine 20μM R07 exp423	2.29
Hippuristanol 0.12μM R08 exp488	2.34
Rapamycin 0.001μM R08 exp429	2.35
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	2.41
Staurosporine 0.02μM R08 exp524	2.44
Nifuroxazide 5μM R03 exp102	2.48
THZ531 0.11 to 0.175μM on day4 R07 exp413	2.83
THZ531 0.225μM R08 exp444	2.89
Etoposide 0.1μM R05 exp198	3.01
LY2090314 0.003μM R08 exp499	3.41
Pyridostatin 4μM R05 exp240	3.59
Oligomycin-A 2μM R00 exp25	3.8
ML-792 0.2μM R08 exp505	4.18

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 13999
Expression level (log2 read counts): 6.43

Expression Distribution

Gene	Correlation
KAT7	0.591
ARID4B	0.551
RBM26	0.48
BRMS1	0.475
SAP130	0.45
SLC25A1	0.442
ING1	0.435
PCGF1	0.419
SUDS3	0.403

Bromodomain
EPL1
PHD

MOZ/MORF histone acetyltransferase complex
response to immobilization stress
response to electrical stimulus
histone H3 acetylation
histone acetylation
internal peptidyl-lysine acetylation
peptidyl-lysine acetylation
internal protein amino acid acetylation
histone binding
perikaryon
protein acetylation
protein acylation
peptidyl-lysine modification
histone modification
covalent chromatin modification
nuclear speck
dendrite
chromatin organization
peptidyl-amino acid modification
chromosome organization
response to abiotic stimulus