FLI1

Entrez Summary: This gene encodes a transcription factor containing an ETS DNA-binding domain. The gene can undergo a t(11;22)(q24;q12) translocation with the Ewing sarcoma gene on chromosome 22, which results in a fusion gene that is present in the majority of Ewing sarcoma cases. An acute lymphoblastic leukemia-associated t(4;11)(q21;q23) translocation involving this gene has also been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012].
UniProt Summary: Sequence-specific transcriptional activator (PubMed:24100448, PubMed:26316623, PubMed:28255014). Recognizes the DNA sequence 5'-C[CA]GGAAGT-3'. {ECO:0000269|PubMed:24100448, ECO:0000269|PubMed:26316623, ECO:0000269|PubMed:28255014}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
LY2090314 0.003μM R08 exp500 no dilution day6	-2.67
I-BRD9 4μM R07 exp365	-2.42
Rapamycin 0.001μM R08 exp429	-2.19
Rapamycin 2μM plus FK-506 5μM R07 exp308	-2.02
FTY720 3μM R08 exp483	-1.95
THZ531 0.11 to 0.175μM on day4 R07 exp413	-1.93
A-366 10μM R03 exp115	-1.91
Dimethyloxaloylglycine 100μM R05 exp229	-1.91
Rapamycin 1μM R00 exp29	-1.83
Radicicol 0.16μM R05 exp242	-1.82
THZ531 0.11 to 0.125μM on day4 R07 exp410	-1.8
Vemurafenib 6.6μM R08 exp434	-1.8
Rapamycin 2μM R07 exp306	-1.78
YM155 0.001μM R08 exp432	-1.77
Selumetinib 20μM R02 exp81	-1.76
Chloroquine 32μM R08 exp470	-1.76
BAY-598 4μM R05 exp220	-1.75
Trametinib 10μM R02 exp83	-1.75
Cyclosporin-A 0.8μM R07 exp347	-1.73
Curcumin 6.5μM R06 exp277	-1.72
Chlorpromazine 10μM R07 exp344	-1.7
Ethanol 0.01 R05 exp234	-1.7
Geldanamycin 0.015 to 0.05μM on day4 R07 exp317	-1.7
MK2206 4μM R08 exp504	-1.7
Rotenone 20μM R00 exp34	1.81
Cerivastatin 0.15μM R05 exp226	1.92
Fluvastatin 2.2μM R06 exp282	1.98
A-196 10μM R03 exp114	2.06
UM131593 0.2μM R03 exp106	2.6

Global Fraction of Cell Lines Where Essential: 4/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	3/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Ets
SAM PNT

megakaryocyte development
megakaryocyte differentiation
bone cell development
myeloid cell development
RNA polymerase II distal enhancer sequence-specific DNA binding
bone development
myeloid cell differentiation
nuclear body
hemostasis
blood circulation
chromatin binding
circulatory system process
DNA-binding transcription activator activity, RNA polymerase II-specific
skeletal system development
regulation of body fluid levels
RNA polymerase II proximal promoter sequence-specific DNA binding
hemopoiesis
hematopoietic or lymphoid organ development
immune system development
DNA-binding transcription factor activity
animal organ morphogenesis
positive regulation of transcription by RNA polymerase II
DNA binding
positive regulation of transcription, DNA-templated
DNA-binding transcription factor activity, RNA polymerase II-specific
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
cell development
positive regulation of RNA metabolic process
positive regulation of nucleobase-containing compound metabolic process
positive regulation of macromolecule biosynthetic process
system process
positive regulation of cellular biosynthetic process
positive regulation of gene expression
positive regulation of biosynthetic process