FOXRED1

Entrez Summary: This gene encodes a protein that contains a FAD-dependent oxidoreductase domain. The encoded protein is localized to the mitochondria and may function as a chaperone protein required for the function of mitochondrial complex I. Mutations in this gene are associated with mitochondrial complex I deficiency. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010].
UniProt Summary: Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) (PubMed:20858599, PubMed:25678554). Involved in mid-late stages of complex I assembly (PubMed:25678554). {ECO:0000269|PubMed:20858599, ECO:0000269|PubMed:25678554}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Mubritinib 0.2μM R02 exp65	1.7
Artemisinin 50μM R08 exp450	1.73
Clomiphene 4.4μM R02 exp68	1.73
Chloroquine 32μM R08 exp470	1.74
Torin1 0.08μM R02 exp82	1.85
2-Methoxyestradiol 0.55 to 0.75μM on day4 R07 exp311	1.89
Amiloride 100μM R08 exp447	1.91
Atovaquone 15μM R08 exp451	1.95
GSK-J4 1.5μM R08 exp441	1.98
GSK626616 14μM R08 exp485	2.04
Cannabidiol 13μM R08 exp465	2.09
Oligomycin-A 2μM R00 exp25	2.11
Arsenate 40μM R06 exp264	2.13
UM0125461 0.74μM R02 exp84	2.21
Genistein 15μM R07 exp360	2.28
Ribavirin 10 to 15μM on day4 R04 exp160	2.34
HMS-I2 10μM R06 exp288	4.61

Global Fraction of Cell Lines Where Essential: 3/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	1/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	1/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

mitochondrial respiratory chain complex I
NADH dehydrogenase complex assembly
mitochondrial respiratory chain complex I assembly
mitochondrial respiratory chain complex assembly
oxidoreductase activity
mitochondrial inner membrane
mitochondrion organization
cellular protein-containing complex assembly
oxidation-reduction process
mitochondrion
protein-containing complex assembly
protein-containing complex subunit organization