ID3

Entrez Summary: N/A
UniProt Summary: Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Involved in myogenesis by inhibiting skeletal muscle and cardiac myocyte differentiation and promoting muscle precursor cells proliferation. Inhibits the binding of E2A-containing protein complexes to muscle creatine kinase E-box enhancer. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. {ECO:0000269|PubMed:8437843}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Rapamycin 10μM R00 exp30	-2.44
Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307	-2.27
Rapamycin 1μM R00 exp29	-2.24
Rapamycin 0.001μM R08 exp429	-2.18
Pomalidomide 20μM R07 exp391	-2.06
Hypoxia 5%O2 R04 exp191	-1.97
Rapamycin 2μM R07 exp306	-1.87
GSK-LSD1 10μM R03 exp123	-1.85
PFI-3 10μM R03 exp144	-1.82
Wiskostatin 3μM R07 exp422	-1.79
Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471	-1.75
SNS-032 15μM R08 exp443	1.75
Deferoxamine 11μM R07 exp350	1.76
Etoposide 0.3μM R05 exp199	1.81
Tanespimycin 14μM R08 exp527	1.82
THZ531 0.225μM R08 exp444	1.87
Rucaparib 6.5μM R08 exp520	1.89
Diepoxybutane 3μM R07 exp354	1.9
TIC10 10μM R08 exp532	1.95
Aphidicolin 0.4μM R08 exp440	2.03
Cerivastatin 0.15μM R05 exp226	2.06
Atovaquone 15μM R08 exp451	2.07
CI-1040 9.5μM R08 exp472	2.07
JQ1 0.8μM R08 exp435	2.1
Mitomycin-C 0.06μM R08 exp503	2.11
Monensin 0.3μM R08 exp507	2.19
BVD-523 15μM R02 exp67	2.22
Mdivi-1 15μM R05 exp217	2.39
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	2.43
Rotenone 20μM R00 exp34	2.66
3-Bromopyruvate 7μM R04 exp175	3
BML-284 0.09μM R08 exp460	3.1
Actinomycin-D 0.001μM R00 exp3	3.25
5-Fluorouracil 20μM R00 exp2	3.28
UMK57 1μM R01 exp59	3.59
UM131593 0.2μM R03 exp106	5.92
LY2090314 0.003μM R08 exp500 no dilution day6	5.99
LY2090314 0.003μM R08 exp499	6.11

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

leptomycin B binding
response to leptomycin B
cellular response to leptomycin B
notochord development
negative regulation of myoblast differentiation
negative regulation of osteoblast differentiation
regulation of myoblast differentiation
negative regulation of DNA binding
cellular response to fatty acid
RNA polymerase II transcription factor binding
negative regulation of ossification
metanephros development
response to fatty acid
regulation of DNA replication
regulation of osteoblast differentiation
cellular response to antibiotic
odontogenesis
regulation of DNA binding
circadian rhythm
protein dimerization activity
negative regulation of DNA-binding transcription factor activity
negative regulation of binding
regulation of ossification
cellular response to acid chemical
negative regulation of neuron differentiation
transcription corepressor activity
protein domain specific binding
kidney development
rhythmic process
renal system development
negative regulation of neurogenesis
muscle organ development
response to antibiotic
negative regulation of nervous system development
urogenital system development
transcription factor binding
negative regulation of cell development
response to acid chemical
regulation of binding
regulation of DNA-binding transcription factor activity