MTERFD1

Entrez Summary: N/A
UniProt Summary: Binds promoter DNA and regulates initiation of transcription (PubMed:17662942). Required for normal mitochondrial transcription and translation, and for normal assembly of mitochondrial respiratory complexes. Required for normal mitochondrial function (By similarity). Maintains 16S rRNA levels and functions in mitochondrial ribosome assembly by regulating the biogenesis of the 39S ribosomal subunit (By similarity). {ECO:0000250|UniProtKB:Q8R3J4, ECO:0000269|PubMed:17662942}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
WYE-354 6μM R02 exp90	1.71
Hydroxyurea 100μM R07 exp329	1.73
Hippuristanol 0.12μM R08 exp489 no dilution day6	1.84
Arsenate 40μM R06 exp264	1.88
Thimerosal 0.85μM R08 exp529	1.98
Oligomycin-A 2μM R00 exp25	2.7

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	1/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

mitochondrial ribosome assembly
mitochondrial transcription
mitochondrial RNA metabolic process
ribosome assembly
double-stranded DNA binding
mitochondrial translation
mitochondrial gene expression
macroautophagy
mitochondrial outer membrane
transcription regulatory region DNA binding
ribonucleoprotein complex assembly
ribonucleoprotein complex subunit organization
process utilizing autophagic mechanism
autophagy
ribosome biogenesis
translation
peptide biosynthetic process
ribonucleoprotein complex biogenesis
amide biosynthetic process
peptide metabolic process
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
organelle assembly
cellular amide metabolic process
cellular protein-containing complex assembly
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
negative regulation of transcription, DNA-templated
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
mitochondrion
organic cyclic compound biosynthetic process
negative regulation of RNA metabolic process
negative regulation of cellular macromolecule biosynthetic process
organonitrogen compound biosynthetic process
negative regulation of nucleobase-containing compound metabolic process
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process