NSUN4

Entrez Summary: N/A
UniProt Summary: Involved in mitochondrial ribosome assembly. 5- methylcytosine rRNA methyltransferase that probably is involved in mitochondrial ribosome small subunit (SSU) maturation by methylation of mitochondrial 12S rRNA; the function is independent of MTERFD2/MTERF4 and assembled mitochondrial ribosome large subunit (LSU). Targeted to LSU by MTERFD2/MTERF4 and probably is involved in a final step in ribosome biogenesis to ensure that SSU and LSU are assembled. In vitro can methylate 16S rRNA of the LSU; the methylation is enhanced by MTERFD/MTERF4. {ECO:0000269|PubMed:21531335, ECO:0000269|PubMed:23022348}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 10/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	1/26
breast	1/33
central nervous system	0/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	1/21
liver	1/20
lung	2/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

rRNA (cytosine-C5-)-methyltransferase activity
mature ribosome assembly
small ribosomal subunit rRNA binding
positive regulation of mitochondrial translation
regulation of mitochondrial translation
rRNA methylation
regulation of mitochondrial gene expression
rRNA modification
methyltransferase activity
mitochondrial large ribosomal subunit
ribosome assembly
RNA methylation
positive regulation of translation
positive regulation of cellular amide metabolic process
RNA modification
rRNA processing
rRNA metabolic process
ribonucleoprotein complex assembly
ribonucleoprotein complex subunit organization
macromolecule methylation
ribosome biogenesis
methylation
regulation of translation
mitochondrial matrix
ncRNA processing
regulation of cellular amide metabolic process
ribonucleoprotein complex biogenesis
ncRNA metabolic process
posttranscriptional regulation of gene expression
organelle assembly
cellular protein-containing complex assembly
RNA processing
protein-containing complex assembly
positive regulation of cellular protein metabolic process
RNA metabolic process
positive regulation of protein metabolic process
protein-containing complex subunit organization
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
positive regulation of gene expression