SEPSECS

Gene Information

Official Symbol: SEPSECS
Official Name: Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase
Aliases and Previous Symbols: N/A
Entrez ID: 51091
UniProt: Q9HD40
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The amino acid selenocysteine is the only amino acid that does not have its own tRNA synthetase. Instead, this amino acid is synthesized on its cognate tRNA in a three step process. The protein encoded by this gene catalyzes the third step in the process, the conversion of O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec).[provided by RefSeq, Mar 2011].
UniProt Summary: Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl- tRNA(Sec) required for selenoprotein biosynthesis. {ECO:0000269|PubMed:17142313}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Ribavirin 10 to 15μM on day4 R04 exp160	-3.15
Ixabepilone 0.004 to 0.005μM on day4 R04 exp184	-2.9
Apcin 50 to 100μM on day4 R04 exp176	-2.6
BH1 1μM R04 exp169	-2.55
Benzoate 10000μM R08 exp455	-2.53
Etoposide 10μM R00 exp20	-2.47
Vincristine 0.0005μM R04 exp190	-2.47
Epothilone-B 0.0015μM R05 exp231	-2.42
A-395N 10μM R05 exp219	-2.4
1-Methyl-nicotinamide-chloride 1000μM R03 exp113	-2.35
Etoposide 0.1μM R05 exp198	-2.33
MKC9989 10μM R03 exp133	-2.33
Epothilone-D 0.004 to 0.006μM on day4 R05 exp232	-2.29
Tubacin 1.6μM R07 exp416	-2.28
Arsenic trioxide 60μM R08 exp449	-2.26
Docetaxel 0.001 to 0.002μM on day4 R04 exp159	-2.25
proTAME 5μM R04 exp187	-2.22
Selumetinib 20μM R02 exp81	-2.21
UM0125461 0.74μM R02 exp84	-2.11
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	-2.08
BML-284 0.09μM R08 exp460	-2.06
Nicotinamide Riboside 100μM R03 exp139	-2.05
Cabazitaxel 0.001μM R05 exp223	-2.03
Nicotinate 1000μM R03 exp140	-2.01
Taxol 0.004μM R03 exp103	-2
L-74142 5μM R03 exp131	-1.99
Parthenolide 2.5μM R05 exp238	-1.98
GSK-LSD1 10μM R03 exp123	-1.97
Temozolomide 200μM R04 exp189	-1.94
JQ1 0.01μM R03 exp130	-1.93
BI-2536 0.0042μM R03 exp95	-1.91
Myriocin 25μM R06 exp293	-1.91
Artemisinin 50μM R08 exp450	-1.9
A-196 10μM R03 exp114	-1.89
Geldanamycin 0.015 to 0.025μM on day4 R07 exp316	-1.88
Phenformin 20μM R03 exp143	-1.88
Apcin 25μM plus proTAME 2μM R04 exp177	-1.86
GW501516 25μM R06 exp285	-1.83
Radicicol 0.16μM R05 exp242	-1.82
Cisplatin 0.35μM R06 exp273	-1.8
CVT-10216 0.1μM R06 exp278	-1.8
Palbociclib 1μM R07 exp382	-1.75
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179	-1.74
Ammonium tetrathiomolybdate 10μM R08 exp448	-1.7
ABT-702 5μM plus CoCl2 18μM R07 exp320	1.7
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	1.71
CoCl2 18μM R07 exp346	2.1
UM0129480 7μM R02 exp85	2.58
KU-0063794 3.8μM R02 exp71	2.84
HMS-I2 10μM R06 exp288	3.5

Global Fraction of Cell Lines Where Essential: 168/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	4/28
blood	6/28
bone	13/26
breast	7/33
central nervous system	22/56
cervix	0/4
colorectal	0/17
esophagus	2/13
fibroblast	1/1
gastric	3/16
kidney	7/21
liver	11/20
lung	15/75
lymphocyte	5/16
ovary	6/26
pancreas	3/24
peripheral nervous system	3/16
plasma cell	3/15
prostate	0/1
skin	4/24
soft tissue	2/9
thyroid	1/2
upper aerodigestive	4/22
urinary tract	7/29
uterus	3/5

Essentiality in NALM6

Essentiality Rank: 244
Expression level (log2 read counts): 5.39

Expression Distribution

Gene	Correlation
EEFSEC	0.657
GCLC	0.452
PSTK	0.444
PPCDC	0.442
DDX39A	0.421
PTAR1	0.409

transferase activity, transferring selenium-containing groups
selenocysteinyl-tRNA(Sec) biosynthetic process
selenocysteine metabolic process
translational readthrough
selenocysteine incorporation
serine family amino acid metabolic process
tRNA binding
translational elongation
tRNA metabolic process
alpha-amino acid metabolic process
cellular amino acid metabolic process
regulation of translation
translation
regulation of cellular amide metabolic process
peptide biosynthetic process
ncRNA metabolic process
posttranscriptional regulation of gene expression
amide biosynthetic process
peptide metabolic process
RNA biosynthetic process
cellular amide metabolic process
carboxylic acid metabolic process
oxoacid metabolic process
organic acid metabolic process
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
organic cyclic compound biosynthetic process
organonitrogen compound biosynthetic process
cellular nitrogen compound biosynthetic process
RNA metabolic process
cellular macromolecule biosynthetic process
small molecule metabolic process
macromolecule biosynthetic process
gene expression