UBQLN1

Gene Information

Official Symbol: UBQLN1
Official Name: ubiquilin 1
Aliases and Previous Symbols: N/A
Entrez ID: 29979
UniProt: Q9UMX0
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes an ubiquitin-like protein (ubiquilin) that shares a high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain an N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and thus are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to modulate accumulation of presenilin proteins, and it is found in lesions associated with Alzheimer's and Parkinson's disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Bisphenol A 100μM R06 exp269	-1.86
Etoposide 0.1μM R05 exp198	1.71
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	1.74
Vinblastine 0.002μM R01 exp60	1.8
Citral 75μM R06 exp275	1.83
Benzoate 10000μM R08 exp455	1.93
GSK-J4 1-1.25μM to day4 R07 exp363	1.95
Tozasertib 0.1μM R07 exp414	1.99
Atovaquone 15μM R08 exp451	2
Cytochalasin-B 5μM R07 exp349	2
UMK57 1μM R01 exp59	2
MLN-4924 2μM R00 exp22	2.03
Hydroxyurea 100μM R07 exp329	2.05
UM131593 0.2μM R03 exp106	2.1
Aphidicolin 0.4μM R08 exp440	2.13
PU-H71 1μM R08 exp515	2.18
CI-1040 9.5μM R08 exp472	2.19
42°C R08 exp539	2.24
6-Thio-2-deoxyguanosine 2μM R06 exp259	2.33
Wortmannin 5μM R00 exp38	2.49
Pyridostatin 4μM R05 exp240	2.51
Hippuristanol 0.12μM R08 exp488	2.62
Artemisinin 50μM R08 exp450	2.64
Dinaciclib 0.007μM R07 exp355	2.72
RO-3307 4.7μM R02 exp80	2.76
Latrunculin-B 10μM R07 exp374	2.87
AICAR 240μM R05 exp211	2.92
Olaparib 4μM R08 exp512	2.95
Hippuristanol 0.12μM R08 exp489 no dilution day6	2.98
Thimerosal 0.85μM R08 exp529	3.07
Tanespimycin 14μM R08 exp527	3.14
Dorsomorphin 5μM R07 exp357	3.17
Rotenone 20μM R00 exp34	3.19
Doxorubicin 0.02μM R08 exp478	3.35
AICAR 240μM R03 exp116	3.43
Bortezomib 0.005μM R00 exp6	3.48
Etoposide 1μM R00 exp19	3.7
Mitomycin-C 0.06μM R08 exp503	3.78
UM0129480 7μM R02 exp85	3.87
GSK626616 14μM R08 exp485	4
MS023 2μM R03 exp134	4.01
Bleomycin 5μM R08 exp459	4.09
Pimelic-diphenylamide-106 5μM R00 exp28	4.23
Etoposide 0.3μM R05 exp199	4.33
Ethanol 0.01 R05 exp234	4.38
Staurosporine 0.02μM R08 exp524	4.94
5-Fluorouracil 20μM R00 exp2	5.17
MS023 7μM R03 exp135	6.33
Actinomycin-D 0.001μM R00 exp3	6.9
Benzoate 20000μM R08 exp456	6.91

Gene	Correlation
BAK1	0.781
MARCH5	0.755
PLAA	0.741
VDAC2	0.741
APAF1	0.726
CASP9	0.712
FAF2	0.676
SERF2	0.66
CYCS	0.628
HCCS	0.611
DIABLO	0.595
DOHH	0.581
ENY2	0.553
MFN1	0.553
HSPD1	0.542
ATAD1	0.538
GFPT1	0.523
STAU1	0.522
THG1L	0.514
GABPA	0.499
UAP1	0.491
BAP1	0.487
RPTOR	0.486
ZZZ3	0.486
MTOR	0.478
RAD23B	0.475
GMPPB	0.474
ROMO1	0.466
TRIAP1	0.466
DDHD2	0.458
HARS	0.458
UBE2K	0.453
MEAF6	0.44
KDSR	0.434
UBE2G2	0.429
GTF3A	0.427
TRIM28	0.426
PPP2R3C	0.426
CUL3	0.426
TADA2A	0.424
NAE1	0.424
MLST8	0.424
NUDC	0.422
NXT1	0.421
NSD1	0.417
METAP2	0.415
VHL	0.414
DPAGT1	0.409
BPTF	0.407
PMM2	0.406
RNMT	0.405
GNAS	0.405
LAMTOR5	0.403
SEC16A	0.401
ATP5J	0.401

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 17571
Expression level (log2 read counts): 7.4

Expression Distribution

Rad60-SLD
UBA
ubiquitin

negative regulation of store-operated calcium channel activity
negative regulation of toll-like receptor 3 signaling pathway
positive regulation of ER-associated ubiquitin-dependent protein catabolic process
aggrephagy
regulation of store-operated calcium channel activity
regulation of ER-associated ubiquitin-dependent protein catabolic process
regulation of toll-like receptor 3 signaling pathway
positive regulation of ERAD pathway
selective autophagy
regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
regulation of ERAD pathway
polyubiquitin modification-dependent protein binding
autophagosome maturation
negative regulation of calcium ion transmembrane transporter activity
positive regulation of response to endoplasmic reticulum stress
negative regulation of toll-like receptor signaling pathway
negative regulation of calcium ion transmembrane transport
negative regulation of cation channel activity
aggresome
proteasome complex
negative regulation of calcium ion transport
autophagosome assembly
regulation of oxidative stress-induced cell death
autophagosome organization
regulation of toll-like receptor signaling pathway
autophagosome
negative regulation of ion transmembrane transporter activity
ubiquitin-dependent ERAD pathway
regulation of cellular response to oxidative stress
negative regulation of transporter activity
negative regulation of cation transmembrane transport
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
regulation of response to endoplasmic reticulum stress
regulation of response to oxidative stress
regulation of calcium ion transmembrane transporter activity
ERAD pathway
kinase binding
negative regulation of ion transmembrane transport
positive regulation of ubiquitin-dependent protein catabolic process
positive regulation of proteasomal protein catabolic process