CASP9

Entrez Summary: This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein can undergo autoproteolytic processing and activation by the apoptosome, a protein complex of cytochrome c and the apoptotic peptidase activating factor 1; this step is thought to be one of the earliest in the caspase activation cascade. This protein is thought to play a central role in apoptosis and to be a tumor suppressor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]. COMPLETENESS: complete on the 3' end.
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
GSK-J4 1μM R07 exp362	-1.89
Deguelin 0.15μM R05 exp209	1.76
6-Thio-2-deoxyguanosine 2μM R06 exp259	1.78
Ethanol 0.01 R05 exp234	1.82
UM0129480 7μM R02 exp85	1.83
Tanespimycin 14μM R08 exp527	1.84
Diepoxybutane 3μM R07 exp354	1.91
Nutlin-3A 1.6μM R06 exp294	1.94
Bortezomib 0.05μM R00 exp7	1.97
Rotenone 2μM R00 exp33	2.08
Bleomycin 5μM R08 exp459	2.16
Atovaquone 15μM R08 exp451	2.29
Artemisinin 50μM R08 exp450	2.3
JQ1 0.8μM R08 exp435	2.32
CI-1040 9.5μM R08 exp472	2.41
AICAR 240μM R05 exp211	2.72
PU-H71 1μM R08 exp515	2.74
GSK-J4 1.5μM R08 exp441	2.75
MS023 2μM R03 exp134	2.81
Etoposide 1μM R00 exp19	2.86
Rotenone 20μM R00 exp34	2.87
AICAR 240μM R03 exp116	2.93
THZ1 0.06μM R08 exp531	2.97
Etoposide 0.3μM R05 exp199	3.09
Hippuristanol 0.12μM R08 exp488	3.2
Staurosporine 0.02μM R08 exp524	3.26
SNS-032 15μM R08 exp443	3.33
Olaparib 4μM R08 exp512	3.35
RO-3307 4.7μM R02 exp80	3.43
Aphidicolin 0.4μM R08 exp440	3.68
Benzoate 20000μM R08 exp456	3.7
Pimelic-diphenylamide-106 5μM R00 exp28	3.97
Hippuristanol 0.12μM R08 exp489 no dilution day6	4.25
5-Fluorouracil 20μM R00 exp2	4.44
CR131-b 0.005μM R08 exp474	4.44
Mitomycin-C 0.06μM R08 exp503	4.57
Doxorubicin 0.02μM R08 exp478	4.85
MS023 7μM R03 exp135	5.94
Actinomycin-D 0.001μM R00 exp3	5.97

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution