CCT7

Entrez Summary: This gene encodes a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 5 and 6. [provided by RefSeq, Oct 2009].
UniProt Summary: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Tubastatin-A 2.5μM R07 exp417	-1.96
NN-Diethyl-meta-toluamide 500μM R08 exp438	-1.77
Brefeldin A 0.02μM R00 exp8	1.73
Doxorubicin 0.02μM R08 exp478	1.73
SNS-032 15μM R08 exp443	1.76
NFN1 1μM R03 exp100	1.83
CI-1040 9.5μM R08 exp472	1.86
Rotenone 2μM R00 exp33	1.87
MLN-4924 2μM R00 exp22	1.9
Actinomycin-D 0.001μM R00 exp3	1.91
Amiloride 100μM R08 exp447	1.94
Rotenone 20μM R00 exp34	1.94
BVD-523 15μM R02 exp67	1.99
Pimelic-diphenylamide-106 5μM R00 exp28	2.43
Actinomycin-D 0.01μM R00 exp4	2.57
Etoposide 1μM R00 exp19	3.16

Global Fraction of Cell Lines Where Essential: 12/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	1/26
breast	1/33
central nervous system	1/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	1/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	1/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution