HIST1H2BE

Gene Information

Official Symbol: H2BC6
Official Name: H2B clustered histone 6
Aliases and Previous Symbols: N/A
Entrez ID: 8344
UniProt: P62807
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Gene	Correlation
ORC1	0.527
PSMB4	0.525
SNRPA1	0.511
SUPT6H	0.505
TCEB3C	0.504
NUPL1	0.504
ORC6	0.502
RAD51	0.5
TICRR	0.496
VASN	0.495
COPB1	0.493
AAMP	0.491
TRAIP	0.491
CCDC94	0.49
CDC73	0.49
TCEB3CL2	0.489
ARCN1	0.483
ADRA1D	0.482
TBC1D3G	0.481
NFATC4	0.479
CDC6	0.479
HAP1	0.478
TBC1D3F	0.477
DTL	0.475
SF3A1	0.471
NAPA	0.471
CHAF1A	0.471
PSMD1	0.47
COPG1	0.469
DNTTIP2	0.469
GOLGA8H	0.468
RAD21	0.467
RFC1	0.466
CWC22	0.461
TCEB3CL	0.46
TBC1D3H	0.459
PSMA6	0.458
COX8A	0.458
KPNB1	0.457
TOP1MT	0.456
ELMOD3	0.455
AQR	0.455
ZNF106	0.455
LRR1	0.454
SEC13	0.454
C1QTNF9B	0.454
PSAP	0.453
RPL14	0.453
NUP160	0.453
ATP6V1C1	0.452
PSMD3	0.451
ZNF655	0.45
RBM39	0.45
RPS2	0.45
KCTD17	0.448
RPL34	0.447
PSMB1	0.445
TPX2	0.445
RPL30	0.445
PSMD7	0.445
GOLGA8J	0.444
RAN	0.444
TIMELESS	0.442
HIST2H2BF	0.441
GOLGA6L6	0.441
RPL35	0.44
TFIP11	0.439
TBC1D3K	0.438
PSMD11	0.438
DDX56	0.438
TBC1D3L	0.438
TBC1D3E	0.438
TBC1D3I	0.438
NUFIP2	0.438
POLR1A	0.435
TTC31	0.433
UPF1	0.43
COPB2	0.43
C14orf93	0.429
ATP6V0C	0.429
CBWD3	0.429
TBC1D3	0.429
MT1E	0.429
PAN3	0.429
CCNA2	0.429
SYT9	0.428
CCDC64B	0.428
SLC4A1	0.427
COPZ1	0.426
CHD4	0.426
GID4	0.425
PSMB3	0.424
DDTL	0.424
PSMC6	0.423
PAN2	0.422
PLK1	0.422
YTHDC1	0.42
NARFL	0.42
HNRNPA1	0.42
CBWD5	0.419
PSMD14	0.419
EXOSC5	0.418
AKIRIN2	0.418
RILPL1	0.418
NOL10	0.417
CDCA3	0.417
ZNF830	0.416
DIDO1	0.416
NUP153	0.416
POLA1	0.415
SCAF1	0.415
EXD1	0.415
VPS54	0.415
HIST2H3C	0.414
HIST2H3A	0.414
DDX23	0.413
SSH2	0.413
PSMC2	0.413
GAR1	0.412
STIL	0.412
TGM5	0.412
TBC1D3C	0.412
PLA2G4F	0.412
SUPT5H	0.411
UBL5	0.411
MED17	0.41
RPS12	0.41
GOSR2	0.41
POLA2	0.408
CDC45	0.408
ACSF2	0.408
BAGE2	0.408
PCF11	0.408
ISCU	0.407
BAGE5	0.407
EGR2	0.407
BAGE4	0.407
HGC6.3	0.407
BAGE3	0.407
BAGE	0.407
LIPE	0.406
FBXW9	0.406
ITGA2B	0.405
IGFN1	0.405
C2orf27B	0.405
NUP205	0.405
GOLGA8O	0.404
UBAP1	0.404
IK	0.403
COPA	0.403
RPS28	0.403
AAAS	0.403
OGFR	0.402
AHCTF1	0.401
TUBA8	0.4
NPIPB8	0.4
GOLGA8K	0.4

Global Fraction of Cell Lines Where Essential: 91/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	3/28
blood	11/28
bone	4/26
breast	5/33
central nervous system	3/56
cervix	0/4
colorectal	1/17
esophagus	2/13
fibroblast	0/1
gastric	2/16
kidney	3/21
liver	0/20
lung	6/75
lymphocyte	3/16
ovary	5/26
pancreas	0/24
peripheral nervous system	6/16
plasma cell	3/15
prostate	1/1
skin	4/24
soft tissue	1/9
thyroid	0/2
upper aerodigestive	2/22
urinary tract	4/29
uterus	1/5

Essentiality in NALM6

Essentiality Rank: 1532
Expression level (log2 read counts): -4.27

Expression Distribution