HIST2H3A
Gene Information
- Official Symbol: H3C15
- Official Name: H3 clustered histone 15
- Aliases and Previous Symbols: N/A
- Entrez ID: 333932
- UniProt: Q71DI3
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: N/A
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Pfam Domains GO Terms
Pfam Domains
| Histone |
GO Terms
| chromatin silencing at rDNA |
| interleukin-7-mediated signaling pathway |
| response to interleukin-7 |
| cellular response to interleukin-7 |
| nucleosomal DNA binding |
| regulation of megakaryocyte differentiation |
| chromatin organization involved in negative regulation of transcription |
| chromatin silencing |
| nucleosome |
| chromatin organization involved in regulation of transcription |
| negative regulation of gene expression, epigenetic |
| regulation of gene silencing by miRNA |
| regulation of gene silencing by RNA |
| regulation of posttranscriptional gene silencing |
| nucleosome assembly |
| regulation of gene silencing |
| chromatin assembly |
| gene silencing |
| chromatin assembly or disassembly |
| nucleosome organization |
| DNA packaging |
| protein-DNA complex assembly |
| regulation of myeloid cell differentiation |
| regulation of gene expression, epigenetic |
| protein-DNA complex subunit organization |
| blood coagulation |
| coagulation |
| hemostasis |
| DNA conformation change |
| regulation of hemopoiesis |
| wound healing |
| protein heterodimerization activity |
| regulation of body fluid levels |
| response to wounding |
| cytokine-mediated signaling pathway |
| chromatin organization |
| cellular protein-containing complex assembly |
| cellular response to cytokine stimulus |
| chromosome organization |
| response to cytokine |
| negative regulation of transcription, DNA-templated |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of RNA metabolic process |
| negative regulation of cellular macromolecule biosynthetic process |
| negative regulation of nucleobase-containing compound metabolic process |
| negative regulation of macromolecule biosynthetic process |
| negative regulation of cellular biosynthetic process |
| negative regulation of biosynthetic process |
| protein-containing complex assembly |
| regulation of immune system process |
| negative regulation of gene expression |
| regulation of cell differentiation |
| protein-containing complex subunit organization |
| extracellular region |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Etoposide 0.1μM R05 exp198 | 1.75 |
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| POLR2J3 | 0.574 |
| SF3A1 | 0.543 |
| PSMB4 | 0.536 |
| TCEB3CL2 | 0.523 |
| IGFN1 | 0.513 |
| CHD4 | 0.512 |
| NPIPB5 | 0.51 |
| POLA1 | 0.506 |
| TCEB3C | 0.503 |
| COPG1 | 0.503 |
| PAF1 | 0.501 |
| UPF1 | 0.5 |
| C14orf93 | 0.5 |
| GOLGA6L3 | 0.499 |
| C1QTNF9B | 0.499 |
| TCEB3CL | 0.498 |
| POLA2 | 0.498 |
| RPS2 | 0.497 |
| UQCRH | 0.492 |
| HIST1H4B | 0.49 |
| MT1E | 0.488 |
| PAN3 | 0.487 |
| SLC4A1 | 0.483 |
| PWP2 | 0.483 |
| VASN | 0.483 |
| TBC1D3L | 0.483 |
| TBC1D3K | 0.482 |
| TBC1D3E | 0.482 |
| ORC1 | 0.482 |
| HAP1 | 0.482 |
| TBC1D3I | 0.481 |
| COPE | 0.477 |
| PSMD3 | 0.476 |
| SEC13 | 0.476 |
| USP35 | 0.475 |
| MED17 | 0.474 |
| PSAP | 0.473 |
| POLR2F | 0.472 |
| RPL35 | 0.471 |
| COX7A2L | 0.469 |
| TBC1D3C | 0.468 |
| RBBP5 | 0.466 |
| RPS9 | 0.465 |
| KCTD17 | 0.463 |
| PDE4DIP | 0.462 |
| GOLGA8O | 0.462 |
| RRP7A | 0.46 |
| PSMB2 | 0.459 |
| FAM160A1 | 0.457 |
| SNRPA1 | 0.456 |
| NCAPG | 0.455 |
| BYSL | 0.455 |
| INCENP | 0.455 |
| DISP2 | 0.454 |
| RPS19 | 0.453 |
| CBWD5 | 0.453 |
| HINFP | 0.451 |
| CBWD3 | 0.451 |
| SFPQ | 0.451 |
| GOLGA6L4 | 0.45 |
| TBC1D3H | 0.45 |
| POLE | 0.447 |
| SLC38A7 | 0.446 |
| ORC6 | 0.446 |
| TBC1D3 | 0.443 |
| UTP3 | 0.443 |
| RPS5 | 0.442 |
| WDR75 | 0.441 |
| CGB2 | 0.439 |
| NUP160 | 0.439 |
| CDC73 | 0.436 |
| TSPY8 | 0.435 |
| RPS20 | 0.435 |
| NPIPB8 | 0.435 |
| NFATC4 | 0.435 |
| SLC6A17 | 0.434 |
| CCNA2 | 0.431 |
| TRIM52 | 0.431 |
| EBNA1BP2 | 0.431 |
| PSMD1 | 0.431 |
| CHAF1A | 0.431 |
| TBC1D3G | 0.43 |
| TBC1D3F | 0.43 |
| KIAA0947 | 0.429 |
| TYMS | 0.428 |
| EXOSC5 | 0.427 |
| CTR9 | 0.427 |
| PAN2 | 0.427 |
| ARCN1 | 0.427 |
| TWISTNB | 0.427 |
| RRN3 | 0.426 |
| SUPT6H | 0.426 |
| IK | 0.425 |
| CBWD6 | 0.425 |
| SSH2 | 0.425 |
| RAD51 | 0.424 |
| FAM231A | 0.423 |
| RPS7 | 0.423 |
| CLCN6 | 0.423 |
| FAM231C | 0.423 |
| LRR1 | 0.422 |
| AAMP | 0.422 |
| SF3B2 | 0.42 |
| PSMB1 | 0.42 |
| AQR | 0.42 |
| COL2A1 | 0.42 |
| POLR2D | 0.419 |
| HIST2H2BF | 0.419 |
| NUP54 | 0.418 |
| PSMD2 | 0.418 |
| TUBA8 | 0.417 |
| TRAIP | 0.417 |
| ATP13A1 | 0.416 |
| KIF3C | 0.416 |
| DDTL | 0.416 |
| LAD1 | 0.416 |
| MDM2 | 0.416 |
| HIST1H2BE | 0.414 |
| ZNF574 | 0.414 |
| MYT1L | 0.413 |
| NUPL1 | 0.412 |
| TFIP11 | 0.412 |
| RPS19BP1 | 0.411 |
| ANKLE2 | 0.41 |
| CCDC116 | 0.41 |
| RRP15 | 0.41 |
| CWC22 | 0.41 |
| DOCK6 | 0.409 |
| MFSD12 | 0.409 |
| ZNF655 | 0.408 |
| ABHD8 | 0.408 |
| CEP192 | 0.408 |
| MSH5 | 0.407 |
| BID | 0.407 |
| DAND5 | 0.406 |
| RAD21 | 0.406 |
| NOP16 | 0.405 |
| SNRNP200 | 0.405 |
| INTS5 | 0.405 |
| KRT78 | 0.404 |
| GGA3 | 0.404 |
| PARP3 | 0.404 |
| DDX56 | 0.404 |
| CANT1 | 0.403 |
| SUPT5H | 0.403 |
| HIVEP3 | 0.403 |
| ATP6V0C | 0.403 |
| EXOSC9 | 0.401 |
| RPL38 | 0.401 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 721/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 1/1 |
| bile duct | 28/28 |
| blood | 27/28 |
| bone | 26/26 |
| breast | 29/33 |
| central nervous system | 54/56 |
| cervix | 4/4 |
| colorectal | 17/17 |
| esophagus | 13/13 |
| fibroblast | 1/1 |
| gastric | 16/16 |
| kidney | 21/21 |
| liver | 20/20 |
| lung | 75/75 |
| lymphocyte | 16/16 |
| ovary | 25/26 |
| pancreas | 24/24 |
| peripheral nervous system | 15/16 |
| plasma cell | 14/15 |
| prostate | 1/1 |
| skin | 23/24 |
| soft tissue | 9/9 |
| thyroid | 2/2 |
| upper aerodigestive | 21/22 |
| urinary tract | 29/29 |
| uterus | 4/5 |
Essentiality in NALM6
- Essentiality Rank: 1333
- Expression level (log2 read counts): -0.71
Expression Distribution
HIST2H3A Expression in NALM6 Cells: -0.71
