Pfam Domains GO Terms
| RNA pol Rpb6 |
| RNA polymerase II activity |
| RNA polymerase I activity |
| RNA polymerase I complex |
| RNA polymerase II, core complex |
| RNA polymerase III activity |
| RNA polymerase III complex |
| transcription elongation from RNA polymerase I promoter |
| termination of RNA polymerase I transcription |
| DNA-directed 5-3 RNA polymerase activity |
| 7-methylguanosine mRNA capping |
| 7-methylguanosine RNA capping |
| RNA capping |
| transcription initiation from RNA polymerase I promoter |
| transcription by RNA polymerase I |
| positive regulation of viral transcription |
| transcription by RNA polymerase III |
| positive regulation of gene expression, epigenetic |
| regulation of viral transcription |
| somatic stem cell population maintenance |
| snRNA transcription by RNA polymerase II |
| snRNA transcription |
| DNA-templated transcription, termination |
| transcription-coupled nucleotide-excision repair |
| transcription elongation from RNA polymerase II promoter |
| positive regulation of type I interferon production |
| fibroblast growth factor receptor signaling pathway |
| regulation of gene silencing by miRNA |
| regulation of gene silencing by RNA |
| regulation of posttranscriptional gene silencing |
| DNA-templated transcription, elongation |
| ncRNA transcription |
| positive regulation of viral process |
| cellular response to fibroblast growth factor stimulus |
| nucleotide-excision repair |
| response to fibroblast growth factor |
| regulation of type I interferon production |
| regulation of gene silencing |
| fibrillar center |
| stem cell population maintenance |
| maintenance of cell number |
| transcription initiation from RNA polymerase II promoter |
| regulation of viral process |
| DNA-templated transcription, initiation |
| regulation of symbiosis, encompassing mutualism through parasitism |
| regulation of gene expression, epigenetic |
| RNA splicing, via transesterification reactions with bulged adenosine as nucleophile |
| mRNA splicing, via spliceosome |
| RNA splicing, via transesterification reactions |
| RNA splicing |
| positive regulation of cytokine production |
| mRNA processing |
| transcription by RNA polymerase II |
| cellular response to growth factor stimulus |
| DNA repair |
| positive regulation of multi-organism process |
| transmembrane receptor protein tyrosine kinase signaling pathway |
| response to growth factor |
| transcription, DNA-templated |
| nucleic acid-templated transcription |
| RNA biosynthetic process |
| regulation of cytokine production |
| mRNA metabolic process |
| enzyme linked receptor protein signaling pathway |
| DNA metabolic process |
| regulation of multi-organism process |
| cellular response to DNA damage stimulus |
| RNA processing |
| nucleobase-containing compound biosynthetic process |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| cellular response to endogenous stimulus |
| organic cyclic compound biosynthetic process |
| DNA binding |
| response to endogenous stimulus |
| cellular nitrogen compound biosynthetic process |
| RNA metabolic process |
| cellular response to stress |
| cellular macromolecule biosynthetic process |
| positive regulation of multicellular organismal process |
| macromolecule biosynthetic process |
| positive regulation of gene expression |
| gene expression |
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
| Gene | Correlation |
|---|---|
| CHD4 | 0.544 |
| COPG1 | 0.531 |
| PSMB4 | 0.512 |
| NPIPB5 | 0.503 |
| COX7A2L | 0.491 |
| SF3A1 | 0.491 |
| SLC4A1 | 0.488 |
| C14orf93 | 0.486 |
| TCEB3CL2 | 0.485 |
| NUPL1 | 0.481 |
| HIST2H3C | 0.472 |
| HIST2H3A | 0.472 |
| NUP160 | 0.469 |
| AAMP | 0.468 |
| PSMD2 | 0.468 |
| RPS12 | 0.467 |
| POLE | 0.466 |
| TWISTNB | 0.465 |
| PSMD11 | 0.463 |
| PSMB2 | 0.463 |
| PSMA7 | 0.463 |
| COPZ1 | 0.462 |
| STIL | 0.462 |
| FAM25B | 0.461 |
| MT1E | 0.46 |
| EXOSC5 | 0.458 |
| CBWD5 | 0.455 |
| CBWD3 | 0.454 |
| HAP1 | 0.447 |
| AKIRIN2 | 0.446 |
| DDTL | 0.441 |
| GGA3 | 0.441 |
| VASN | 0.441 |
| ORC1 | 0.441 |
| AQR | 0.437 |
| SLC38A7 | 0.436 |
| MYT1L | 0.436 |
| UBE2Q2L | 0.435 |
| RPL35 | 0.435 |
| CBWD6 | 0.435 |
| BRD2 | 0.434 |
| TCEB3C | 0.431 |
| SUPT5H | 0.431 |
| LRR1 | 0.43 |
| UTP3 | 0.428 |
| HINFP | 0.428 |
| TUBA8 | 0.427 |
| POLR2D | 0.425 |
| TCEB3CL | 0.425 |
| TFIP11 | 0.424 |
| NCAPG | 0.424 |
| KCTD17 | 0.423 |
| RAD51 | 0.423 |
| COL2A1 | 0.423 |
| SYT9 | 0.422 |
| SNRPA1 | 0.422 |
| TSG101 | 0.422 |
| TBC1D3H | 0.421 |
| ATP1A3 | 0.421 |
| RBBP5 | 0.421 |
| RPS2 | 0.42 |
| DDX56 | 0.419 |
| DISP2 | 0.419 |
| GID4 | 0.419 |
| AHCTF1 | 0.417 |
| BYSL | 0.416 |
| GOLGA6L3 | 0.416 |
| CACTIN | 0.416 |
| BRIX1 | 0.416 |
| PWP2 | 0.415 |
| TBC1D3G | 0.414 |
| NFATC4 | 0.414 |
| RRP7A | 0.413 |
| ARHGEF15 | 0.412 |
| NUP133 | 0.412 |
| GOLGA6L4 | 0.412 |
| ISCU | 0.411 |
| SLC6A17 | 0.411 |
| SSH2 | 0.411 |
| DTL | 0.411 |
| GPRIN2 | 0.41 |
| C1QTNF9B | 0.409 |
| TYMS | 0.409 |
| NUP54 | 0.409 |
| NARFL | 0.408 |
| RANGAP1 | 0.408 |
| PSMA6 | 0.408 |
| RANBP2 | 0.407 |
| PSMD14 | 0.406 |
| PAN3 | 0.405 |
| TIMELESS | 0.405 |
| ALDH1B1 | 0.405 |
| NOL8 | 0.404 |
| S1PR4 | 0.404 |
| RPSA | 0.403 |
| PLA2G4F | 0.403 |
| CCNA2 | 0.402 |
| PSMB1 | 0.402 |
| VPS54 | 0.401 |
| AKT1S1 | 0.401 |
| CDC73 | 0.401 |
| ATP6V1C1 | 0.401 |
| COPA | 0.401 |
| PDE4DIP | 0.4 |
| PLRG1 | 0.4 |
| KRT2 | 0.4 |
| ATP6AP1 | 0.4 |
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 0/1 |
| bile duct | 23/28 |
| blood | 25/28 |
| bone | 18/25 |
| breast | 18/33 |
| central nervous system | 41/56 |
| cervix | 3/4 |
| colorectal | 12/17 |
| esophagus | 12/13 |
| fibroblast | 1/1 |
| gastric | 10/15 |
| kidney | 9/21 |
| liver | 16/20 |
| lung | 47/75 |
| lymphocyte | 10/14 |
| ovary | 17/26 |
| pancreas | 17/24 |
| peripheral nervous system | 12/16 |
| plasma cell | 12/15 |
| prostate | 1/1 |
| skin | 13/24 |
| soft tissue | 4/7 |
| thyroid | 1/2 |
| upper aerodigestive | 12/22 |
| urinary tract | 17/29 |
| uterus | 5/5 |
Expression Distribution