PSMD14
Gene Information
- Official Symbol: PSMD14
- Official Name: proteasome 26S subunit, non-ATPase 14
- Aliases and Previous Symbols: N/A
- Entrez ID: 10213
- UniProt: O00487
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. The PSMD14 subunit is a metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains within the complex. Plays a role in response to double-strand breaks (DSBs): acts as a regulator of non- homologous end joining (NHEJ) by cleaving 'Lys-63'-linked polyubiquitin, thereby promoting retention of JMJD2A/KDM4A on chromatin and restricting TP53BP1 accumulation. Also involved in homologous recombination repair by promoting RAD51 loading. {ECO:0000269|PubMed:1317798, ECO:0000269|PubMed:22909820, ECO:0000269|PubMed:9374539}.
Pfam Domains GO Terms
Pfam Domains
| Mov34 |
GO Terms
| cytosolic proteasome complex |
| endopeptidase activator activity |
| proteasome regulatory particle, lid subcomplex |
| Lys63-specific deubiquitinase activity |
| proteasome accessory complex |
| proteasome binding |
| protein K63-linked deubiquitination |
| thiol-dependent ubiquitinyl hydrolase activity |
| proteasome complex |
| double-strand break repair via nonhomologous end joining |
| regulation of cellular amino acid metabolic process |
| metallopeptidase activity |
| non-recombinational repair |
| regulation of hematopoietic stem cell differentiation |
| antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent |
| regulation of transcription from RNA polymerase II promoter in response to hypoxia |
| antigen processing and presentation of exogenous peptide antigen via MHC class I |
| NIK/NF-kappaB signaling |
| regulation of cellular amine metabolic process |
| anaphase-promoting complex-dependent catabolic process |
| regulation of hematopoietic progenitor cell differentiation |
| negative regulation of G2/M transition of mitotic cell cycle |
| SCF-dependent proteasomal ubiquitin-dependent protein catabolic process |
| interleukin-1-mediated signaling pathway |
| Wnt signaling pathway, planar cell polarity pathway |
| double-strand break repair via homologous recombination |
| antigen processing and presentation of peptide antigen via MHC class I |
| recombinational repair |
| negative regulation of cell cycle G2/M phase transition |
| thiol-dependent ubiquitin-specific protease activity |
| regulation of establishment of planar polarity |
| stimulatory C-type lectin receptor signaling pathway |
| innate immune response activating cell surface receptor signaling pathway |
| secretory granule lumen |
| regulation of stem cell differentiation |
| tumor necrosis factor-mediated signaling pathway |
| regulation of transcription from RNA polymerase II promoter in response to stress |
| ficolin-1-rich granule lumen |
| regulation of DNA-templated transcription in response to stress |
| response to ethanol |
| non-canonical Wnt signaling pathway |
| positive regulation of canonical Wnt signaling pathway |
| regulation of cellular ketone metabolic process |
| positive regulation of endopeptidase activity |
| Fc-epsilon receptor signaling pathway |
| cellular response to interleukin-1 |
| negative regulation of canonical Wnt signaling pathway |
| T cell receptor signaling pathway |
| positive regulation of Wnt signaling pathway |
| antigen processing and presentation of exogenous peptide antigen |
| regulation of mRNA stability |
| regulation of morphogenesis of an epithelium |
| double-strand break repair |
| regulation of proteasomal protein catabolic process |
| antigen processing and presentation of exogenous antigen |
| regulation of RNA stability |
| cellular response to hypoxia |
| antigen processing and presentation of peptide antigen |
| positive regulation of peptidase activity |
| regulation of G2/M transition of mitotic cell cycle |
| cellular response to decreased oxygen levels |
| response to interleukin-1 |
| regulation of mRNA catabolic process |
| negative regulation of Wnt signaling pathway |
| regulation of cell cycle G2/M phase transition |
| negative regulation of mitotic cell cycle phase transition |
| cellular response to oxygen levels |
| antigen processing and presentation |
| regulation of proteolysis involved in cellular protein catabolic process |
| DNA recombination |
| negative regulation of cell cycle phase transition |
| response to alcohol |
| innate immune response-activating signal transduction |
| cellular response to tumor necrosis factor |
| Fc receptor signaling pathway |
| regulation of cellular protein catabolic process |
| activation of innate immune response |
| regulation of animal organ morphogenesis |
| response to tumor necrosis factor |
| protein deubiquitination |
| regulation of canonical Wnt signaling pathway |
| antigen receptor-mediated signaling pathway |
| protein modification by small protein removal |
| protein polyubiquitination |
| response to antibiotic |
| negative regulation of mitotic cell cycle |
| proteasome-mediated ubiquitin-dependent protein catabolic process |
| negative regulation of cell cycle process |
| regulation of mRNA metabolic process |
| positive regulation of innate immune response |
| response to hypoxia |
| proteasomal protein catabolic process |
| Wnt signaling pathway |
| positive regulation of proteolysis |
| response to decreased oxygen levels |
| cell-cell signaling by wnt |
| regulation of Wnt signaling pathway |
| positive regulation of response to biotic stimulus |
| post-translational protein modification |
| MAPK cascade |
| response to oxygen levels |
| regulation of protein catabolic process |
| signal transduction by protein phosphorylation |
| regulation of mitotic cell cycle phase transition |
| regulation of endopeptidase activity |
| regulation of small molecule metabolic process |
| cell surface receptor signaling pathway involved in cell-cell signaling |
| regulation of peptidase activity |
| regulation of cell cycle phase transition |
| immune response-activating cell surface receptor signaling pathway |
| regulation of hemopoiesis |
| regulation of innate immune response |
| positive regulation of defense response |
| immune response-regulating cell surface receptor signaling pathway |
| neutrophil degranulation |
| neutrophil activation involved in immune response |
| neutrophil mediated immunity |
| neutrophil activation |
| granulocyte activation |
| response to toxic substance |
| positive regulation of multi-organism process |
| DNA repair |
| leukocyte degranulation |
| myeloid leukocyte mediated immunity |
| myeloid cell activation involved in immune response |
| regulation of response to biotic stimulus |
| posttranscriptional regulation of gene expression |
| ubiquitin-dependent protein catabolic process |
| modification-dependent protein catabolic process |
| modification-dependent macromolecule catabolic process |
| immune response-activating signal transduction |
| negative regulation of cell cycle |
| myeloid leukocyte activation |
| proteolysis involved in cellular protein catabolic process |
| immune response-regulating signaling pathway |
| positive regulation of response to external stimulus |
| cellular protein catabolic process |
| leukocyte activation involved in immune response |
| cell activation involved in immune response |
| activation of immune response |
| regulation of mitotic cell cycle |
| cytokine-mediated signaling pathway |
| protein catabolic process |
| protein ubiquitination |
| regulated exocytosis |
| regulation of proteolysis |
| DNA metabolic process |
| regulation of cell cycle process |
| regulation of defense response |
| leukocyte mediated immunity |
| positive regulation of hydrolase activity |
| protein modification by small protein conjugation |
| cellular response to DNA damage stimulus |
| regulation of multi-organism process |
| exocytosis |
| regulation of cellular catabolic process |
| positive regulation of immune response |
| cellular macromolecule catabolic process |
| leukocyte activation |
| protein phosphorylation |
| protein modification by small protein conjugation or removal |
| regulation of catabolic process |
| secretion by cell |
| cellular response to cytokine stimulus |
| response to drug |
| export from cell |
| macromolecule catabolic process |
| regulation of anatomical structure morphogenesis |
| organonitrogen compound catabolic process |
| cell activation |
| immune effector process |
| regulation of response to external stimulus |
| response to cytokine |
| cell-cell signaling |
| secretion |
| positive regulation of immune system process |
| regulation of immune response |
| response to abiotic stimulus |
| regulation of cell cycle |
| negative regulation of signal transduction |
| proteolysis |
| transmembrane transport |
| regulation of hydrolase activity |
| phosphorylation |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of catalytic activity |
| regulation of response to stress |
| response to oxygen-containing compound |
| positive regulation of cellular protein metabolic process |
| negative regulation of response to stimulus |
| regulation of immune system process |
| positive regulation of signal transduction |
| intracellular signal transduction |
| cellular response to stress |
| positive regulation of protein metabolic process |
| organic substance catabolic process |
| positive regulation of molecular function |
| cellular catabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| immune response |
| extracellular region |
| vesicle-mediated transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| PSMA6 | 0.578 |
| TCEB3CL2 | 0.555 |
| TCEB3C | 0.553 |
| SLC6A17 | 0.528 |
| TCEB3CL | 0.522 |
| PSMD11 | 0.519 |
| VASN | 0.518 |
| PSMC2 | 0.51 |
| ZFAND5 | 0.503 |
| NUP160 | 0.502 |
| UPF1 | 0.498 |
| CDC73 | 0.496 |
| PSMB2 | 0.495 |
| DDTL | 0.491 |
| LRR1 | 0.491 |
| PSMB4 | 0.485 |
| PWP2 | 0.483 |
| RBM39 | 0.481 |
| CHD4 | 0.481 |
| MYO1H | 0.479 |
| PSMD2 | 0.478 |
| RRP7A | 0.478 |
| PAN3 | 0.478 |
| SMG1 | 0.477 |
| PAN2 | 0.475 |
| DTL | 0.473 |
| RPL35 | 0.472 |
| NOP16 | 0.467 |
| PSMD1 | 0.466 |
| TBC1D3H | 0.463 |
| BRIX1 | 0.463 |
| MT1E | 0.462 |
| KRT2 | 0.461 |
| SMG7 | 0.459 |
| PSMB1 | 0.458 |
| ATP6V1C1 | 0.457 |
| PSMB3 | 0.457 |
| ZNF830 | 0.456 |
| ORC6 | 0.456 |
| ORC1 | 0.454 |
| PSMC6 | 0.45 |
| AAMP | 0.449 |
| AKIRIN2 | 0.448 |
| AAAS | 0.447 |
| SUPT6H | 0.446 |
| TBC1D3G | 0.445 |
| EXOSC6 | 0.444 |
| RPS2 | 0.444 |
| TPX2 | 0.443 |
| CGB2 | 0.443 |
| BRD2 | 0.443 |
| RPS12 | 0.441 |
| SF3A1 | 0.441 |
| COL2A1 | 0.44 |
| PSMC5 | 0.44 |
| COPG1 | 0.439 |
| PAF1 | 0.439 |
| PSMA7 | 0.437 |
| PRPF8 | 0.437 |
| RFC1 | 0.437 |
| MED17 | 0.436 |
| TBC1D3K | 0.435 |
| TBC1D3L | 0.435 |
| PSMC4 | 0.435 |
| TBC1D3E | 0.435 |
| TBC1D3I | 0.434 |
| CACTIN | 0.434 |
| RBBP5 | 0.433 |
| ISCU | 0.432 |
| KCTD17 | 0.432 |
| NOL10 | 0.432 |
| RNF113A | 0.428 |
| MYH7B | 0.427 |
| GOLGA6L6 | 0.426 |
| CLN6 | 0.422 |
| KPNB1 | 0.422 |
| POLR1A | 0.42 |
| LAD1 | 0.42 |
| NPIPB5 | 0.419 |
| HIST1H2BE | 0.419 |
| TWISTNB | 0.418 |
| BYSL | 0.418 |
| PSMD3 | 0.418 |
| RPA2 | 0.417 |
| AHCTF1 | 0.417 |
| HAP1 | 0.416 |
| CTR9 | 0.416 |
| FBL | 0.416 |
| TBC1D3C | 0.415 |
| CCNA2 | 0.414 |
| PSMC1 | 0.413 |
| DDT | 0.413 |
| NUP54 | 0.412 |
| CHCHD3 | 0.411 |
| TIMELESS | 0.411 |
| ACSF2 | 0.41 |
| SH3BP1 | 0.41 |
| EIF4A3 | 0.408 |
| ARCN1 | 0.408 |
| POLA1 | 0.408 |
| TICRR | 0.407 |
| UQCRH | 0.407 |
| POLA2 | 0.407 |
| POLR2F | 0.406 |
| XAB2 | 0.406 |
| CCDC116 | 0.405 |
| RRN3 | 0.404 |
| SLC38A7 | 0.404 |
| NELFCD | 0.403 |
| MADCAM1 | 0.403 |
| NBPF10 | 0.403 |
| PSMC3 | 0.402 |
| SNIP1 | 0.402 |
| NBPF16 | 0.402 |
| SCAF1 | 0.401 |
| TBC1D3F | 0.4 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 725/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 1/1 |
| bile duct | 28/28 |
| blood | 28/28 |
| bone | 25/25 |
| breast | 33/33 |
| central nervous system | 56/56 |
| cervix | 4/4 |
| colorectal | 17/17 |
| esophagus | 13/13 |
| fibroblast | 1/1 |
| gastric | 15/15 |
| kidney | 21/21 |
| liver | 20/20 |
| lung | 75/75 |
| lymphocyte | 14/14 |
| ovary | 26/26 |
| pancreas | 24/24 |
| peripheral nervous system | 16/16 |
| plasma cell | 15/15 |
| prostate | 1/1 |
| skin | 24/24 |
| soft tissue | 6/7 |
| thyroid | 2/2 |
| upper aerodigestive | 22/22 |
| urinary tract | 29/29 |
| uterus | 5/5 |
Essentiality in NALM6
- Essentiality Rank: 48
- Expression level (log2 read counts): 6.24
Expression Distribution
PSMD14 Expression in NALM6 Cells: 6.24
