RPL34
Gene Information
- Official Symbol: RPL34
- Official Name: ribosomal protein L34
- Aliases and Previous Symbols: N/A
- Entrez ID: 6164
- UniProt: P49207
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Component of the large ribosomal subunit. {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:25901680, ECO:0000269|PubMed:25957688, ECO:0000305|PubMed:12962325}.
Pfam Domains GO Terms
Pfam Domains
| Ribosomal L34e |
GO Terms
| cytosolic large ribosomal subunit |
| SRP-dependent cotranslational protein targeting to membrane |
| cotranslational protein targeting to membrane |
| protein targeting to ER |
| establishment of protein localization to endoplasmic reticulum |
| viral transcription |
| nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
| viral gene expression |
| protein localization to endoplasmic reticulum |
| translational initiation |
| protein targeting to membrane |
| structural constituent of ribosome |
| nuclear-transcribed mRNA catabolic process |
| mRNA catabolic process |
| RNA catabolic process |
| establishment of protein localization to membrane |
| cadherin binding |
| protein targeting |
| nucleobase-containing compound catabolic process |
| translation |
| peptide biosynthetic process |
| establishment of protein localization to organelle |
| heterocycle catabolic process |
| cellular nitrogen compound catabolic process |
| aromatic compound catabolic process |
| protein localization to membrane |
| organic cyclic compound catabolic process |
| amide biosynthetic process |
| peptide metabolic process |
| mRNA metabolic process |
| viral process |
| protein localization to organelle |
| symbiotic process |
| cellular amide metabolic process |
| interspecies interaction between organisms |
| cellular macromolecule catabolic process |
| intracellular protein transport |
| endoplasmic reticulum |
| macromolecule catabolic process |
| RNA binding |
| organonitrogen compound biosynthetic process |
| protein transport |
| intracellular transport |
| peptide transport |
| amide transport |
| cellular protein localization |
| cellular macromolecule localization |
| establishment of protein localization |
| cellular nitrogen compound biosynthetic process |
| RNA metabolic process |
| cellular macromolecule biosynthetic process |
| negative regulation of gene expression |
| macromolecule biosynthetic process |
| organic substance catabolic process |
| cellular catabolic process |
| establishment of localization in cell |
| nitrogen compound transport |
| gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| TCEB3CL2 | 0.508 |
| RPL35 | 0.507 |
| C1QTNF9B | 0.499 |
| ZNF655 | 0.497 |
| RPL38 | 0.494 |
| TBC1D3H | 0.493 |
| ORC1 | 0.487 |
| RPL30 | 0.482 |
| PSMB4 | 0.48 |
| DDTL | 0.479 |
| TBC1D3E | 0.476 |
| TBC1D3I | 0.476 |
| TBC1D3L | 0.476 |
| TBC1D3K | 0.475 |
| TBC1D3G | 0.473 |
| CEP192 | 0.472 |
| PSMA6 | 0.471 |
| TFIP11 | 0.467 |
| C14orf93 | 0.467 |
| POLR2J3 | 0.464 |
| TBC1D3C | 0.464 |
| ORC6 | 0.463 |
| RPL9 | 0.463 |
| RPS12 | 0.462 |
| WDR43 | 0.461 |
| RPS19BP1 | 0.459 |
| CCDC94 | 0.459 |
| TBC1D3F | 0.457 |
| FAM160A1 | 0.457 |
| CBWD3 | 0.457 |
| TCEB3CL | 0.457 |
| TBC1D3 | 0.456 |
| RPL17 | 0.455 |
| COPB1 | 0.453 |
| SYT9 | 0.45 |
| EXOSC3 | 0.45 |
| CBWD5 | 0.45 |
| RAD51 | 0.448 |
| CACTIN | 0.447 |
| TCEB3C | 0.447 |
| HIST1H2BE | 0.447 |
| NOL10 | 0.446 |
| OSBP | 0.445 |
| NUPL1 | 0.444 |
| TICRR | 0.444 |
| RRP15 | 0.443 |
| TWISTNB | 0.442 |
| ANKLE1 | 0.442 |
| MKI67IP | 0.441 |
| COPZ1 | 0.44 |
| RPL6 | 0.439 |
| ATP6AP2 | 0.437 |
| DDT | 0.436 |
| CBWD6 | 0.436 |
| TP53TG3 | 0.435 |
| TP53TG3B | 0.435 |
| TP53TG3C | 0.435 |
| WDR87 | 0.435 |
| DNTTIP2 | 0.432 |
| TSPY8 | 0.432 |
| ZNF830 | 0.431 |
| ZFAND5 | 0.43 |
| ARCN1 | 0.43 |
| RRN3 | 0.429 |
| RIOK2 | 0.429 |
| KCTD17 | 0.428 |
| RPS2 | 0.428 |
| CHD4 | 0.428 |
| SUPT5H | 0.428 |
| RPL14 | 0.427 |
| COPB2 | 0.425 |
| SNRPA1 | 0.425 |
| BRIX1 | 0.425 |
| PSMD3 | 0.425 |
| NBPF10 | 0.423 |
| TOP1MT | 0.423 |
| COL2A1 | 0.423 |
| FCN2 | 0.421 |
| SUPT6H | 0.421 |
| VASN | 0.421 |
| RPL26 | 0.42 |
| OR10G3 | 0.419 |
| PSMB1 | 0.418 |
| CDC73 | 0.417 |
| COPG1 | 0.417 |
| PCF11 | 0.416 |
| SF3B1 | 0.414 |
| PSMD1 | 0.413 |
| VPS28 | 0.412 |
| GOLGA6L1 | 0.412 |
| MT1E | 0.412 |
| RRP1 | 0.412 |
| SLC4A1 | 0.411 |
| BYSL | 0.41 |
| CDC6 | 0.409 |
| SSH2 | 0.409 |
| RPS28 | 0.408 |
| RNF113A | 0.407 |
| RBM39 | 0.407 |
| PSMB2 | 0.406 |
| SAP30BP | 0.405 |
| NOL9 | 0.405 |
| KRT78 | 0.405 |
| RANBP2 | 0.404 |
| PPIE | 0.403 |
| CDC45 | 0.403 |
| PSMA7 | 0.402 |
| FBXW9 | 0.4 |
| PSMC6 | 0.4 |
| PSMC1 | 0.4 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 260/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 1/1 |
| bile duct | 6/28 |
| blood | 10/28 |
| bone | 6/26 |
| breast | 6/33 |
| central nervous system | 20/56 |
| cervix | 2/4 |
| colorectal | 10/17 |
| esophagus | 2/13 |
| fibroblast | 0/1 |
| gastric | 3/16 |
| kidney | 10/21 |
| liver | 10/20 |
| lung | 27/75 |
| lymphocyte | 8/16 |
| ovary | 10/26 |
| pancreas | 7/24 |
| peripheral nervous system | 4/16 |
| plasma cell | 8/15 |
| prostate | 0/1 |
| skin | 12/24 |
| soft tissue | 6/9 |
| thyroid | 1/2 |
| upper aerodigestive | 8/22 |
| urinary tract | 11/29 |
| uterus | 3/5 |
Essentiality in NALM6
- Essentiality Rank: 886
- Expression level (log2 read counts): 7.85
Expression Distribution
RPL34 Expression in NALM6 Cells: 7.85
