Q15 1 to 2μM on day4 R04 exp164

Putative condensin inhibitor

HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C31H27ClFN7O2 584.19716; found 584.19427

Sensitive/Resistant hits (FDR<0.05)	CRANKS	Score Plot	Top 30 Genes	Screen Similarity	Top 30 Sensitive GO terms	Top 30 Resistant GO terms
43/2	Scores	View	View	View	View	View

Screen	Correlation	Plot
Q15 2.7μM R02 exp79	0.164	View
Vemurafenib 6.6μM R02 exp89	0.103	View
Vemurafenib 6.6μM R08 exp434	0.089	View
SB203580 25μM R03 exp149	0.07	View
Tubacin 1.6μM R07 exp416	0.062	View
UM0125461 0.74μM R02 exp84	0.061	View
Thioridazine 5μM R08 exp530	0.059	View
Wiskostatin 3μM R07 exp422	0.056	View
WYE-354 6μM R02 exp90	0.056	View
BH1 1μM R04 exp169	0.139	View
Clomiphene 4.4μM R02 exp68	0.109	View
BS-181 20μM R08 exp461	0.072	View
Bafilomycin-A1 0.009μM R08 exp454	0.071	View
Lapatinib 5μM R01 exp47	0.069	View
NN-Dimethylsphingosine 2.5μM R08 exp508	0.063	View
CFI-400945 25μM R08 exp469	0.062	View
IU1-47 25μM R04 exp182	0.061	View
L-74142 5μM R03 exp131	0.061	View
∆-9-Tetrahydrocannabinol 30μM R08 exp445	0.061	View
Chlorpromazine 10μM R07 exp344	0.06	View
FTY720 3μM R08 exp483	0.059	View
Monensin 0.3μM R08 exp507	0.052	View

GO Term	Fold Change	Genes
sphinganine metabolic process	613.85	SPTLC2,SPTLC1
CDP-choline pathway	306.93	PCYT1A,CHKA,CEPT1
phosphatidylethanolamine biosynthetic process	272.82	CHKA,CEPT1,PCYT2,SELENOI
sphingomyelin biosynthetic process	184.16	SPTLC2,SGMS1,SPTLC1
sphingomyelin metabolic process	102.31	SPTLC2,SGMS1,SPTLC1
phosphatidylethanolamine metabolic process	94.44	CHKA,CEPT1,PCYT2,SELENOI
ceramide biosynthetic process	45.47	SPTLC2,SGMS1,SPTLC1,ELOVL1
sterol binding	40.25	OSBPL9,SCAP,OSBPL11,OSBPL8
sphingolipid biosynthetic process	30.39	SPTLC2,KDSR,SGMS1,SPTLC1,ELOVL1
membrane lipid biosynthetic process	21.92	SPTLC2,KDSR,SGMS1,SPTLC1,ELOVL1
phospholipid biosynthetic process	21.08	PCYT1A,SPTLC2,CHKA,SGMS1,CEPT1,SPTLC1,PCYT2,SELENOI
phospholipid metabolic process	15.97	PCYT1A,SPTLC2,CHKA,SGMS1,CEPT1,SPTLC1,PCYT2,SELENOI,OSBPL8
glycerophospholipid metabolic process	13.44	PCYT1A,CHKA,CEPT1,PCYT2,SELENOI,OSBPL8
lipid transport	12.60	PITPNB,OSBPL9,CHKA,ATP9B,LDLR,OSBPL11,OSBPL8
organophosphate biosynthetic process	11.87	PCYT1A,SPTLC2,CHKA,SGMS1,CEPT1,SPTLC1,ELOVL1,ACSL4,PCYT2,SELENOI
lipid biosynthetic process	11.78	OSBPL9,PCYT1A,SPTLC2,CHKA,KDSR,SGMS1,SPTLC1,ELOVL1,ACSL4,PCYT2,SELENOI
lipid localization	11.52	PITPNB,OSBPL9,CHKA,ATP9B,LDLR,OSBPL11,OSBPL8
cellular lipid metabolic process	9.05	SCAP,PCYT1A,SPTLC2,CHKA,KDSR,SGMS1,CEPT1,SPTLC1,ELOVL1,ACSL4,PCYT2,SELENOI,OSBPL8
organophosphate metabolic process	7.83	PCYT1A,SPTLC2,CHKA,SGMS1,CEPT1,SPTLC1,ELOVL1,ACSL4,PCYT2,SELENOI,OSBPL8