ALDH18A1

Gene Information

Official Symbol: ALDH18A1
Official Name: aldehyde dehydrogenase 18 family member A1
Aliases and Previous Symbols: N/A
Entrez ID: 5832
UniProt: P54886
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene is a member of the aldehyde dehydrogenase family and encodes a bifunctional ATP- and NADPH-dependent mitochondrial enzyme with both gamma-glutamyl kinase and gamma-glutamyl phosphate reductase activities. The encoded protein catalyzes the reduction of glutamate to delta1-pyrroline-5-carboxylate, a critical step in the de novo biosynthesis of proline, ornithine and arginine. Mutations in this gene lead to hyperammonemia, hypoornithinemia, hypocitrullinemia, hypoargininemia and hypoprolinemia and may be associated with neurodegeneration, cataracts and connective tissue diseases. Alternatively spliced transcript variants, encoding different isoforms, have been described for this gene. [provided by RefSeq, Jul 2008].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
BH1 1μM R04 exp169	-2.72
proTAME 5μM R04 exp187	-2.37
NFN1 0.4μM R03 exp99	-2.28
ABT-702 5μM R06 exp261	-2.17
ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319	-2.1
Epothilone-D 0.004 to 0.006μM on day4 R05 exp232	-2.09
L-BMAA 500 to 750μM on day4 R04 exp185	-2.01
Nicotinate 1000μM R03 exp140	-1.99
UM0130462 0.025 to 0.035μM day4 R05 exp247	-1.98
BAY-598 4μM R05 exp220	-1.93
LJH685 5μM R02 exp73	-1.93
Golgicide-A 4μM R03 exp122	-1.92
Alpha-Amanitin 0.5μM R00 exp5	-1.88
A-395N 10μM R05 exp219	-1.87
NFN1 1μM R03 exp100	-1.84
Wortmannin 0.5μM R00 exp37	-1.83
Metformin 100 to 150μM on day4 R04 exp170	-1.77
A-366 10μM R03 exp115	-1.76
UNC2400 2μM R03 exp156	-1.74
Vitamin-D3 40μM R08 exp536	1.71
ABT-702 5μM plus CoCl2 18μM R07 exp320	1.73
UM0129480 7μM R02 exp85	1.73
Caffeine 2600μM R08 exp463	1.74
Mdivi-1 15μM R05 exp217	1.74
CB-839 10μM R05 exp224	1.76
QNZ 0.01μM R08 exp439	1.76
Trimetrexate 0.03μM R08 exp535	1.76
∆-9-Tetrahydrocannabinol 30μM R08 exp445	1.8
Cerivastatin 0.15μM R05 exp226	1.86
Aphidicolin 0.4μM R08 exp440	1.89
Bafilomycin-A1 0.009μM R08 exp454	1.93
LLY-283 2.6μM R06 exp290	1.96
Bleomycin 5μM R08 exp459	2.01
Atovaquone 15μM R08 exp451	2.02
LY2090314 0.003μM R08 exp499	2.03
Sulforaphane 9μM R08 exp526 no dilution day6	2.06
Ammonium tetrathiomolybdate 10μM R08 exp448	2.09
MLN-4924 0.2μM R00 exp21	2.11
Mubritinib 0.2μM R02 exp65	2.12
Rotenone 0.07μM R08 exp431	2.12
GSK461364A 0.1μM R03 exp126	2.13
BI-2536 0.02μM R03 exp96	2.24
BML-284 0.09μM R08 exp460	2.25
FK-506 30μM R07 exp359	2.26
Chloroquine 32μM R08 exp470	2.36
ONC212 0.15μM R08 exp513	2.37
LY2090314 0.003μM R08 exp500 no dilution day6	2.79
Vemurafenib 6.6μM R08 exp434	2.85
UM131593 0.2μM R03 exp106	3.66

Gene	Correlation
YARS2	0.545
SEC62	0.505
TRMT61A	0.493
LARS2	0.46
BCS1L	0.459
RNASEH1	0.457
PARS2	0.455
MRPS6	0.455
MRPL23	0.45
MRPS26	0.449
DHRSX	0.449
EARS2	0.447
TARS2	0.447
TRMT10A	0.444
C17orf89	0.443
NARS2	0.443
VARS2	0.443
SELRC1	0.431
DAP3	0.429
QRSL1	0.429
DNLZ	0.428
MRPS5	0.426
TMEM242	0.421
C12orf65	0.418
WARS2	0.418
SLC7A1	0.418
PITRM1	0.417
HSD17B10	0.413
MRP63	0.412
NDUFAF7	0.412
SCO2	0.411
FH	0.411
DARS2	0.411
MRPL21	0.41
PET112	0.41
PMVK	0.409
RPUSD4	0.407
POLG	0.406
KIAA0391	0.406
GTPBP10	0.406
FTSJ2	0.403
MTRF1L	0.4

Global Fraction of Cell Lines Where Essential: 17/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	0/26
breast	3/33
central nervous system	0/56
cervix	1/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	1/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	2/16
ovary	2/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	2/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 4911
Expression level (log2 read counts): 8.4

Expression Distribution

Aldedh
AA kinase

glutamate-5-semialdehyde dehydrogenase activity
ornithine biosynthetic process
glutamate 5-kinase activity
citrulline biosynthetic process
proline biosynthetic process
citrulline metabolic process
L-proline biosynthetic process
ornithine metabolic process
proline metabolic process
glutamine family amino acid biosynthetic process
glutamate metabolic process
alpha-amino acid biosynthetic process
glutamine family amino acid metabolic process
cellular amino acid biosynthetic process
dicarboxylic acid metabolic process
alpha-amino acid metabolic process
carboxylic acid biosynthetic process
organic acid biosynthetic process
cellular amino acid metabolic process
mitochondrial inner membrane
drug metabolic process
small molecule biosynthetic process
carboxylic acid metabolic process
oxidation-reduction process
oxoacid metabolic process
organic acid metabolic process
identical protein binding
heterocycle biosynthetic process
mitochondrion
phosphorylation
organic cyclic compound biosynthetic process
RNA binding
organonitrogen compound biosynthetic process
ATP binding
small molecule metabolic process