MRPL41

Entrez Summary: N/A
UniProt Summary: Component of the mitochondrial ribosome large subunit (PubMed:25278503, PubMed:25838379). Also involved in apoptosis and cell cycle (PubMed:16024796, PubMed:16256947). Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins (PubMed:16024796). {ECO:0000269|PubMed:16024796, ECO:0000269|PubMed:16256947, ECO:0000269|PubMed:25278503, ECO:0000269|PubMed:25838379}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Rifampicin 1μM R00 exp31	-2.13
Actinomycin-D 0.01μM R00 exp4	-1.92
Cytochalasin-B 5μM R07 exp349	-1.85
Ethanol 0.01 R05 exp234	1.74
Hydroxyurea 100μM R07 exp329	1.77
Mitomycin-C 0.06μM R08 exp503	1.77
UM131593 0.2μM R03 exp106	1.78
Torin1 0.08μM R02 exp82	1.83
Bisphenol A 100μM R06 exp269	1.89
KU-0063794 3.8μM R02 exp71	1.89
PU-H71 1μM R08 exp515	1.9
Tanespimycin 14μM R08 exp527	1.91
Bleomycin 5μM R08 exp459	1.93
Aphidicolin 0.4μM R08 exp440	2.07
GSK-J4 1.5μM R08 exp441	2.1
MK-1775 0.32μM R02 exp75	2.34
Epigallocatechin gallate 20μM R05 exp230	2.61

Global Fraction of Cell Lines Where Essential: 140/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	5/28
blood	8/28
bone	4/26
breast	8/33
central nervous system	9/56
cervix	2/4
colorectal	4/17
esophagus	4/13
fibroblast	0/1
gastric	5/16
kidney	4/21
liver	5/20
lung	16/75
lymphocyte	3/16
ovary	2/26
pancreas	2/24
peripheral nervous system	3/16
plasma cell	2/15
prostate	0/1
skin	6/24
soft tissue	3/9
thyroid	0/2
upper aerodigestive	5/22
urinary tract	2/29
uterus	0/5

Expression Distribution

mitochondrial large ribosomal subunit
mitochondrial translational elongation
mitochondrial translational termination
translational termination
mitochondrial translation
translational elongation
cellular protein complex disassembly
mitochondrial gene expression
ribonucleoprotein complex
structural constituent of ribosome
protein-containing complex disassembly
translation
mitochondrial inner membrane
cellular component disassembly
peptide biosynthetic process
amide biosynthetic process
peptide metabolic process
cellular amide metabolic process
apoptotic process
programmed cell death
cell death
mitochondrion
cell cycle
RNA binding
organonitrogen compound biosynthetic process
cellular nitrogen compound biosynthetic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
protein-containing complex subunit organization
gene expression