TSPY8

Gene Information

Official Symbol: TSPY8
Official Name: testis specific protein Y-linked 8
Aliases and Previous Symbols: N/A
Entrez ID: 728403
UniProt: P0CW00
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: N/A

Function Summary

Entrez Summary: N/A
UniProt Summary: May be involved in sperm differentiation and proliferation. {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Palbociclib 1μM R07 exp382	-2.03
ONC212 0.15μM R08 exp513	-1.97
Brefeldin A 0.02μM R00 exp8	-1.77
Atovaquone 15μM R08 exp451	-1.73
SNS-032 15μM R08 exp443	-1.7
Nifuroxazide 5μM R03 exp102	1.72
Myriocin 25μM R06 exp293	1.76
Doxycycline 10μM R00 exp18	1.77
Cycloheximide 0.02μM R00 exp14	1.78
Cyclosporin-A 3μM R07 exp348	1.81
GSK343 3μM R03 exp124	1.86
proTAME 5μM R04 exp187	1.88
BI-2536 0.001μM R01 exp41	1.96
Lenalidomide 20μM R07 exp375	2.07
Apcin 25μM plus proTAME 2μM R04 exp177	2.08
GSK2606414 1μM R05 exp236	2.26
Dynasore 7μM R08 exp436	2.36

Gene	Correlation
POLR2J3	0.633
TCEB3CL	0.545
RPS12	0.53
CDC45	0.528
HGC6.3	0.522
TCEB3C	0.519
TFIP11	0.511
PSMB4	0.509
TCEB3CL2	0.508
IK	0.504
NUPL1	0.498
CCNA2	0.495
SNIP1	0.486
C1QTNF9B	0.482
MT1E	0.481
ANKLE1	0.481
CHD4	0.478
PSMA6	0.475
AATF	0.475
BYSL	0.473
LRR1	0.473
NSF	0.473
NPIPB5	0.472
SUPT5H	0.469
RRP7A	0.467
RPL35	0.467
CBWD5	0.464
KCTD17	0.463
TBC1D3H	0.462
SLC6A17	0.46
GOLGA6L1	0.457
CEP192	0.457
SLC4A1	0.455
SUPT6H	0.453
RPS2	0.451
PCF11	0.451
TWISTNB	0.451
VPS28	0.45
AAMP	0.448
MBTD1	0.448
RPS19BP1	0.448
EXOSC9	0.447
CDCA3	0.446
ATP6V1C1	0.446
RRN3	0.446
GOLGA8J	0.445
ORC6	0.444
TBC1D3G	0.444
RPS3A	0.443
ORC1	0.443
HAP1	0.442
TBC1D3C	0.441
RBBP5	0.44
UPF1	0.44
COPG1	0.44
CBWD3	0.439
NFATC4	0.439
S1PR4	0.439
ACSF2	0.438
POLA1	0.436
ZNF655	0.436
COX7A2L	0.435
HIST2H3A	0.435
HIST2H3C	0.434
DOCK6	0.434
EXOSC4	0.433
RPL34	0.432
LOC643669	0.432
OR10G3	0.432
IGFN1	0.431
POLE	0.431
RRP15	0.431
CACTIN	0.431
RPL8	0.43
SMTN	0.428
NUP43	0.426
CDC6	0.425
NARFL	0.424
TERF1	0.424
POLR2J	0.423
PLK4	0.423
GOSR2	0.423
UBAP1	0.422
RAD51	0.422
RPL9	0.422
NOP16	0.422
DTL	0.421
WDR75	0.421
KRT78	0.421
PLEKHA4	0.42
TSG101	0.42
FAM25B	0.42
PSMD3	0.42
RPS19	0.419
TICRR	0.418
MADCAM1	0.418
CBWD6	0.418
RANBP2	0.417
NUP93	0.417
TBC1D3F	0.417
CHMP4B	0.416
RPL6	0.416
TTK	0.416
ARHGEF35	0.414
TIMELESS	0.413
PSMD1	0.413
ZNF830	0.412
TBC1D3E	0.412
TBC1D3I	0.412
DISP2	0.412
DDTL	0.412
XYLT2	0.412
TBC1D3K	0.411
SF3A1	0.411
TBC1D3L	0.411
C14orf93	0.411
GOLGA6L3	0.411
TBC1D3	0.411
ATP6V1A	0.41
AKIRIN2	0.41
STIL	0.409
GGA3	0.409
ACD	0.409
DNTTIP2	0.408
NAPA	0.408
NOL10	0.406
INTS6	0.406
HIST2H2BF	0.405
EXD1	0.404
DDX56	0.404
SLC38A7	0.404
TP53TG3B	0.404
MEPCE	0.403
TP53TG3	0.403
UQCRH	0.403
POLR2J2	0.403
CDT1	0.403
TP53TG3C	0.402
PLA2G4F	0.402
CCDC94	0.402
TAF1	0.401
ARCN1	0.4

Essentiality in NALM6

Essentiality Rank: 1968
Expression level (log2 read counts): -7.68

Expression Distribution

gonadal mesoderm development
nucleosome assembly
mesoderm development
chromatin assembly
chromatin assembly or disassembly
nucleosome organization
DNA packaging
protein-DNA complex assembly
gonad development
development of primary sexual characteristics
mesenchyme development
protein-DNA complex subunit organization
sex differentiation
DNA conformation change
reproductive structure development
reproductive system development
spermatogenesis
male gamete generation
developmental process involved in reproduction
gamete generation
chromatin organization
multicellular organismal reproductive process
sexual reproduction
cellular protein-containing complex assembly
multicellular organism reproduction
multi-organism reproductive process
chromosome organization
reproductive process
reproduction
protein-containing complex assembly
tissue development
protein-containing complex subunit organization