NOL12 [The Human Chemical-Genetic Interaction Map Project]

Gene Information

Official Symbol: NOL12
Official Name: nucleolar protein 12
Aliases and Previous Symbols: N/A
Entrez ID: 79159
UniProt: Q9UGY1
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: May bind to 28S rRNA. {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
NFN1 1μM R03 exp100	1.83
Ribavirin 10μM R01 exp52	1.87
FBS-Wisent 0.1 R07 exp426	1.92
Campthothecin 0.001μM R06 exp270	1.95
Nifuroxazide 1μM R01 exp51	2.17

Gene	Correlation
POLR2J3	0.555
GOLGA6L1	0.555
RPL6	0.521
TBC1D3C	0.515
TCEB3CL	0.509
TCEB3C	0.509
RRP15	0.508
TCEB3CL2	0.503
RPS12	0.503
TBC1D3H	0.503
MCOLN1	0.494
TBC1D3G	0.485
CCNA2	0.477
RPS19BP1	0.475
TBC1D3F	0.469
TICRR	0.466
CDCA3	0.466
PCF11	0.464
AQR	0.459
TBC1D3I	0.459
TBC1D3L	0.458
TBC1D3K	0.458
TBC1D3E	0.458
RAD51	0.456
RPL35	0.455
PSMB4	0.454
RPS2	0.454
EXOSC6	0.453
NPIPB5	0.452
AATF	0.451
TYMS	0.451
CHAF1A	0.449
TBC1D3	0.448
DISP2	0.448
MYO1H	0.445
TFIP11	0.444
WDR87	0.442
PSMD1	0.442
ZNF574	0.442
MKI67IP	0.441
C1QTNF9B	0.441
RPL7A	0.439
SMG1	0.438
NOL10	0.437
RPL15	0.437
TAF1	0.436
USPL1	0.436
ORC1	0.435
SUPT6H	0.435
PSMC2	0.434
COPZ1	0.434
DTL	0.433
KRT78	0.433
HIVEP3	0.433
ZNF106	0.432
PSMC1	0.431
OGFR	0.431
VPS54	0.43
CACTIN	0.429
MYH2	0.429
TSPY1	0.428
SART1	0.427
NIP7	0.427
WDR43	0.426
UTP20	0.426
RPL9	0.425
RANBP2	0.423
ATP6V1A	0.423
SH3BP1	0.422
UPF1	0.422
PAF1	0.422
MED14	0.42
DDTL	0.42
ANKLE2	0.419
POLE	0.419
WDR75	0.418
SFPQ	0.417
VASN	0.417
TIMELESS	0.417
NUP43	0.417
PSMA6	0.415
CWC15	0.415
RFXANK	0.414
MDM2	0.413
GPRIN2	0.412
PSMC5	0.412
NPIPB8	0.412
CHD4	0.412
ZFAND5	0.412
RPL30	0.412
GOLGA8O	0.411
TWISTNB	0.41
CTAGE4	0.41
RPS5	0.41
RPL26	0.409
SUPT5H	0.409
PPM1D	0.408
STRN	0.408
DNM2	0.407
SF3A3	0.406
CDC45	0.405
OSBP	0.405
NUPL1	0.404
RPS3A	0.403
SLC6A17	0.403
RPL37A	0.401
CDC6	0.401
MTCH2	0.4
POLR2A	0.4
GOSR2	0.4

Global Fraction of Cell Lines Where Essential: 87/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	2/28
blood	2/28
bone	3/26
breast	2/33
central nervous system	13/56
cervix	0/4
colorectal	2/17
esophagus	3/13
fibroblast	0/1
gastric	1/16
kidney	2/21
liver	2/20
lung	7/75
lymphocyte	2/16
ovary	2/26
pancreas	4/24
peripheral nervous system	1/16
plasma cell	1/15
prostate	1/1
skin	5/24
soft tissue	1/9
thyroid	0/2
upper aerodigestive	3/22
urinary tract	4/29
uterus	2/5

Essentiality in NALM6

Essentiality Rank: 464
Expression level (log2 read counts): 4.76

Expression Distribution

Last modified: 2026/01/07 22:36
by 127.0.0.1