PMVK

Entrez Summary: This gene encodes a peroxisomal enzyme that is a member of the galactokinase, homoserine kinase, mevalonate kinase, and phosphomevalonate kinase (GHMP) family of ATP-dependent enzymes. The encoded protein catalyzes the conversion of mevalonate 5-phosphate to mevalonate 5-diphosphate, which is the fifth step in the mevalonate pathway of isoprenoid biosynthesis. Mutations in this gene are linked to certain types of porokeratosis including disseminated superficial porokeratosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 80/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	3/28
blood	2/28
bone	1/26
breast	5/33
central nervous system	5/56
cervix	0/4
colorectal	0/17
esophagus	2/13
fibroblast	0/1
gastric	3/16
kidney	2/21
liver	1/20
lung	12/75
lymphocyte	0/16
ovary	0/26
pancreas	5/24
peripheral nervous system	1/16
plasma cell	1/15
prostate	1/1
skin	3/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	6/22
urinary tract	7/29
uterus	0/5

Expression Distribution

phosphomevalonate kinase activity
isopentenyl diphosphate biosynthetic process, mevalonate pathway
isopentenyl diphosphate biosynthetic process
isopentenyl diphosphate metabolic process
response to cholesterol
isoprenoid biosynthetic process
acetyl-CoA metabolic process
response to sterol
cholesterol biosynthetic process
regulation of sterol biosynthetic process
secondary alcohol biosynthetic process
regulation of cholesterol biosynthetic process
sterol biosynthetic process
regulation of cholesterol metabolic process
regulation of alcohol biosynthetic process
regulation of steroid biosynthetic process
thioester metabolic process
acyl-CoA metabolic process
peroxisome
alcohol biosynthetic process
regulation of steroid metabolic process
cholesterol metabolic process
steroid biosynthetic process
secondary alcohol metabolic process
nucleoside bisphosphate metabolic process
purine nucleoside bisphosphate metabolic process
ribonucleoside bisphosphate metabolic process
sterol metabolic process
isoprenoid metabolic process
organic hydroxy compound biosynthetic process
regulation of lipid biosynthetic process
response to alcohol
phospholipid biosynthetic process
coenzyme metabolic process
steroid metabolic process
purine ribonucleotide metabolic process
alcohol metabolic process
ribonucleotide metabolic process
purine nucleotide metabolic process
ribose phosphate metabolic process