SF3A3

Entrez Summary: N/A
UniProt Summary: Subunit of the splicing factor SF3A required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Vinblastine 0.015μM R05 exp208	-1.9
42°C R08 exp539	-1.82
Actinomycin-D 0.01μM R00 exp4	-1.77
IU1-C 25μM R04 exp183	1.7
CHIR-124 0.04μM R06 exp272	1.71
Geldanamycin 0.015 to 0.05μM on day4 R07 exp317	1.72
Salubrinal 20μM R07 exp399	1.76
All-trans-Retinoic-Acid 8μM R07 exp333	1.79
Radicicol 0.16μM R05 exp242	1.82
A-395 10μM R05 exp218	1.84
VE-822 0.04μM R06 exp300	1.89
Dexamethasone 0.006μM R07 exp351	2.14
Thalidomide 20μM R07 exp406	2.25

Global Fraction of Cell Lines Where Essential: 675/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	27/28
blood	26/28
bone	20/26
breast	32/33
central nervous system	51/56
cervix	4/4
colorectal	17/17
esophagus	12/13
fibroblast	1/1
gastric	13/16
kidney	18/21
liver	17/20
lung	67/75
lymphocyte	16/16
ovary	22/26
pancreas	23/24
peripheral nervous system	13/16
plasma cell	15/15
prostate	1/1
skin	22/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	22/22
urinary tract	25/29
uterus	5/5

Expression Distribution

SF3a60 bindingd
DUF3449

U2-type prespliceosome assembly
mRNA 3-splice site recognition
U2 snRNP
mRNA splice site selection
U2-type precatalytic spliceosome
spliceosomal complex assembly
catalytic step 2 spliceosome
spliceosomal complex
ribonucleoprotein complex assembly
ribonucleoprotein complex subunit organization
mRNA splicing, via spliceosome
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
RNA splicing, via transesterification reactions
RNA splicing
nuclear speck
ribonucleoprotein complex biogenesis
mRNA processing
mRNA metabolic process
zinc ion binding
cellular protein-containing complex assembly
RNA processing
RNA binding
protein-containing complex assembly
RNA metabolic process
protein-containing complex subunit organization
gene expression