UBE2H

Gene Information

Official Symbol: UBE2H
Official Name: ubiquitin conjugating enzyme E2 H
Aliases and Previous Symbols: N/A
Entrez ID: 7328
UniProt: P62256
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 11'- and 'Lys-48'-linked polyubiquitination. Capable, in vitro, to ubiquitinate histone H2A. {ECO:0000269|PubMed:20061386, ECO:0000269|PubMed:8132613}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Milciclib 2μM R08 exp502	-5.61
3-Bromopyruvate 7μM R04 exp175	-3.6
Palbociclib 1μM R07 exp382	-3.48
MK-1775 0.32μM R02 exp75	-3.37
FK-506 30μM R07 exp359	-3.17
UMK57 1μM R01 exp59	-2.74
BML-284 0.09μM R08 exp460	-2.51
BVD-523 15μM R02 exp67	-2.25
JQ1 0.8μM R08 exp435	-2.19
Mdivi-1 15μM R05 exp217	-2.11
Pterostilbene 16μM R02 exp78	-2.11
Cryptotanshinone 12μM R05 exp227	-2.08
Quercetin 20μM R08 exp517	-2.05
Artemisinin 50μM R08 exp450	-2.04
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312	-2.02
ABT-702 5μM plus CoCl2 18μM R07 exp320	-1.93
Rotenone 0.07μM R08 exp431	-1.88
TRAIL 5ng/ml R00 exp35	-1.88
Dorsomorphin 5μM R07 exp357	-1.87
Sulforaphane 9μM R08 exp525	-1.75
Deferoxamine 11μM R07 exp350	-1.73
Resveratrol 16μM R03 exp147	-1.71
PF-06409577 20μM R07 exp389	1.71
PT-1 25μM R07 exp392	1.71
GSK343 3μM R03 exp124	1.72
Actinomycin-D 0.01μM R00 exp4	1.78
LJH685 50μM R08 exp433	1.78
MS023 7μM R03 exp135	1.79
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	1.81
Thapsigargin 0.005μM R07 exp407	1.87
Hippuristanol 0.12μM R08 exp488	1.9
THZ531 0.11 to 0.125μM on day4 R07 exp410	1.97
Radicicol 0.16μM R05 exp242	2
Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307	2.09
EPZ-5676 30μM R05 exp233	2.14
Genistein 15μM R07 exp360	2.19
INK128 0.2μM R02 exp70	2.2
Tubacin 1.6μM R07 exp416	2.2
Azithromycin 100μM R08 exp452	2.38
MS023 2μM R03 exp134	2.45
Cerivastatin 0.15μM R05 exp226	2.46
Rapamycin 2μM plus FK-506 5μM R07 exp308	2.46
Dexamethasone 0.006μM R07 exp351	2.72
GSK626616 14μM R08 exp485	2.81
Actinomycin-D 0.001μM R00 exp3	2.86
Fluvastatin 2.2μM R06 exp282	2.88
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	2.89
Etoposide 0.1μM R05 exp198	3.07
Dimethyloxaloylglycine 100μM R05 exp229	3.23
AICAR 240μM R05 exp211	3.31
Rapamycin 0.001μM R08 exp429	4.01
AICAR 240μM R03 exp116	4.42
I-BRD9 4μM R07 exp365	4.5
Rapamycin 1μM R00 exp29	4.64
Rapamycin 10μM R00 exp30	5.73
Rapamycin 2μM R07 exp306	5.95

Gene	Correlation
MAEA	0.805
YPEL5	0.792
WDR26	0.765
GID8	0.733
MEMO1	0.58
RMND5A	0.543
CNOT8	0.487
OTUB1	0.464
CDK8	0.455
RANBP9	0.444
ANP32A	0.428
KDM6A	0.411
UBC	0.408
FKBP1A	0.407
DAZAP1	0.406

Global Fraction of Cell Lines Where Essential: 43/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	0/1
bile duct	4/28
blood	0/28
bone	2/26
breast	5/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	3/16
kidney	0/21
liver	0/20
lung	7/75
lymphocyte	1/16
ovary	1/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	2/15
prostate	0/1
skin	1/24
soft tissue	1/9
thyroid	0/2
upper aerodigestive	2/22
urinary tract	4/29
uterus	1/5

Essentiality in NALM6

Essentiality Rank: 14084
Expression level (log2 read counts): 5.11

Expression Distribution

protein K11-linked ubiquitination
ubiquitin conjugating enzyme activity
protein K48-linked ubiquitination
ubiquitin-protein transferase activity
protein polyubiquitination
proteasome-mediated ubiquitin-dependent protein catabolic process
proteasomal protein catabolic process
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
modification-dependent macromolecule catabolic process
proteolysis involved in cellular protein catabolic process
cellular protein catabolic process
protein catabolic process
protein ubiquitination
protein modification by small protein conjugation
cellular macromolecule catabolic process
protein modification by small protein conjugation or removal
macromolecule catabolic process
organonitrogen compound catabolic process
proteolysis
ATP binding
organic substance catabolic process
cellular catabolic process