VDAC2

Gene Information

Official Symbol: VDAC2
Official Name: voltage dependent anion channel 2
Aliases and Previous Symbols: N/A
Entrez ID: 7417
UniProt: P45880
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation- selective.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Rucaparib 6.5μM R08 exp520	1.73
CI-1040 9.5μM R08 exp472	1.81
Benzoate 10000μM R08 exp455	1.82
LB-100 2μM R05 exp210	1.91
Docosahexaenoic-acid 50μM R07 exp356	1.93
All-trans-Retinoic-Acid 40μM R07 exp334	1.94
Tanespimycin 14μM R08 exp527	2.02
Centrinone 0.5μM R07 exp343	2.08
Cytochalasin-B 5μM R07 exp349	2.08
Trichostatin-A 0.06μM R07 exp415	2.08
UM131593 0.2μM R03 exp106	2.15
Nutlin-3A 1.6μM R06 exp294	2.16
GSK-J4 1.5μM R08 exp441	2.22
Monensin 0.3μM R08 exp507	2.27
Deferoxamine 11μM R07 exp350	2.28
Rotenone 20μM R00 exp34	2.38
Ammonium tetrathiomolybdate 10μM R08 exp448	2.56
GSK-J4 1-1.25μM to day4 R07 exp363	2.56
2-Deoxy-D-glucose 800μM R05 exp214	2.59
Doxorubicin 0.02μM R08 exp478	2.6
Wortmannin 5μM R00 exp38	2.63
UM0129480 7μM R02 exp85	2.66
ML-792 0.2μM R08 exp505	2.67
Latrunculin-B 10μM R07 exp374	2.69
6-Thio-2-deoxyguanosine 2μM R06 exp259	2.71
Tozasertib 0.1μM R07 exp414	2.75
JQ1 0.8μM R08 exp435	2.77
Bleomycin 5μM R08 exp459	2.83
Artemisinin 50μM R08 exp450	2.85
Dinaciclib 0.007μM R07 exp355	2.93
Diepoxybutane 3μM R07 exp354	2.98
Etoposide 1μM R00 exp19	3
AICAR 240μM R05 exp211	3.04
MS023 2μM R03 exp134	3.06
5-Azacytidine 2μM R07 exp330	3.09
THZ1 0.06μM R08 exp531	3.13
RO-3307 4.7μM R02 exp80	3.32
Hippuristanol 0.12μM R08 exp488	3.37
Dorsomorphin 5μM R07 exp357	3.48
Mitomycin-C 0.06μM R08 exp503	3.61
Aphidicolin 0.4μM R08 exp440	3.76
CR131-b 0.005μM R08 exp474	3.76
Olaparib 4μM R08 exp512	3.82
Hippuristanol 0.12μM R08 exp489 no dilution day6	3.83
SNS-032 15μM R08 exp443	3.84
Staurosporine 0.02μM R08 exp524	3.94
GSK626616 14μM R08 exp485	4.39
Etoposide 0.3μM R05 exp199	4.83
Ethanol 0.01 R05 exp234	4.84
Pimelic-diphenylamide-106 5μM R00 exp28	4.91
5-Fluorouracil 20μM R00 exp2	5.29
Actinomycin-D 0.001μM R00 exp3	5.29
AICAR 240μM R03 exp116	5.37
Benzoate 20000μM R08 exp456	6.41
MS023 7μM R03 exp135	6.51

Gene	Correlation
BAK1	0.822
MARCH5	0.802
APAF1	0.756
UBQLN1	0.741
CASP9	0.722
PLAA	0.674
SERF2	0.672
CYCS	0.667
FAF2	0.65
DIABLO	0.627
HCCS	0.606
DOHH	0.597
ATAD1	0.57
MFN1	0.567
ROMO1	0.547
MLST8	0.535
STAU1	0.507
TRIAP1	0.497
GABPA	0.494
BCL2L11	0.488
THG1L	0.487
ENY2	0.483
RPTOR	0.482
METAP2	0.48
HSPD1	0.48
MTOR	0.479
BAP1	0.477
BPTF	0.477
ZZZ3	0.475
UAP1	0.469
CRLS1	0.468
PDPK1	0.463
WDR24	0.46
RAD23B	0.455
FBXO11	0.446
SLMO2	0.446
GFPT1	0.446
DDHD2	0.442
MAPKAP1	0.442
KDSR	0.44
ELF2	0.44
NSD1	0.438
GNAS	0.437
KCTD5	0.437
LAMTOR4	0.435
FECH	0.433
HARS	0.433
MEAF6	0.43
CEPT1	0.43
TP53	0.43
GMPPB	0.423
MIOS	0.422
MCL1	0.421
VHL	0.421
NUDC	0.42
UBE2G2	0.419
SRP14	0.418
SEC16A	0.417
SLC4A7	0.417
OPA1	0.414
WDR59	0.406
TRIM28	0.405
GTF3A	0.403
RPN1	0.4

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	1/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 3799
Expression level (log2 read counts): 6.82

Expression Distribution

porin activity
voltage-gated anion channel activity
pore complex
binding of sperm to zona pellucida
mitochondrial nucleoid
sperm-egg recognition
nucleotide binding
negative regulation of protein polymerization
cell-cell recognition
acrosomal vesicle
negative regulation of intrinsic apoptotic signaling pathway
synaptic vesicle
negative regulation of protein complex assembly
single fertilization
inorganic anion transport
regulation of intrinsic apoptotic signaling pathway
mitochondrial outer membrane
fertilization
regulation of protein polymerization
negative regulation of apoptotic signaling pathway
cell recognition
anion transmembrane transport
regulation of apoptotic signaling pathway
regulation of protein complex assembly
negative regulation of intracellular signal transduction
anion transport
negative regulation of cellular component organization
sexual reproduction
negative regulation of apoptotic process
negative regulation of programmed cell death
ion transmembrane transport
regulation of cellular component biogenesis
multi-organism reproductive process
negative regulation of cell death
mitochondrion
negative regulation of signal transduction
transmembrane transport
negative regulation of cell communication
negative regulation of signaling
ion transport