LAD1

Gene Information

Official Symbol: LAD1
Official Name: ladinin 1
Aliases and Previous Symbols: N/A
Entrez ID: 3898
UniProt: O00515
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Anchoring filament protein which is a component of the basement membrane zone. {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Atovaquone 15μM R08 exp451	-1.86
SB743921 0.001μM R05 exp244	-1.81
BN82002 4μM R07 exp340	1.7
HMS-I2 1μM R06 exp286	1.77
All-trans-Retinoic-Acid 40μM R07 exp334	1.78
Ribavirin 10μM R01 exp52	1.8

Gene	Correlation
PSMB4	0.546
CBWD5	0.528
CHD4	0.52
CBWD3	0.519
DDTL	0.51
RPL35	0.503
POLR2J3	0.489
ZFAND5	0.488
LRR1	0.478
CBWD6	0.474
TBC1D3H	0.473
PSMC6	0.472
RRP7A	0.472
NBPF16	0.468
TBC1D3G	0.467
PSMD6	0.464
SSH2	0.462
TCEB3CL2	0.461
POLE	0.459
C14orf93	0.457
HGC6.3	0.456
CCNA2	0.456
POLA1	0.455
PSMD2	0.454
SUPT6H	0.454
KCTD17	0.452
STIL	0.452
PWP2	0.451
CHCHD3	0.45
NPIPB5	0.45
NUP205	0.45
CACTIN	0.445
TBC1D3C	0.445
TCEB3C	0.444
PSMB2	0.444
NUP160	0.443
RPS2	0.442
SLC38A7	0.442
ZNF583	0.44
PSMD1	0.439
RANBP2	0.439
COPE	0.437
HIVEP3	0.437
SNRPA1	0.437
PRIM1	0.436
MYB	0.436
COPG1	0.435
ALDH1B1	0.434
TCEB3CL	0.434
NUP133	0.434
SART1	0.43
ANKLE2	0.43
NOL9	0.429
HAP1	0.428
PSMA6	0.428
SLC6A17	0.428
AAMP	0.427
NPIPB11	0.426
CCDC94	0.426
UPF1	0.426
DDX56	0.426
MED17	0.425
PAN3	0.425
PSMD3	0.425
RAD21	0.424
BAGE2	0.424
BAGE	0.424
BAGE3	0.424
BAGE4	0.423
RPS5	0.423
SF3A1	0.423
VASN	0.423
BAGE5	0.423
IK	0.423
SUPT5H	0.422
MDM2	0.422
PDE4DIP	0.421
TP53TG3D	0.421
PSMD14	0.42
KPNB1	0.42
PSMA7	0.42
RNPC3	0.419
RPL6	0.419
TBC1D3F	0.418
FBXW9	0.418
RPS9	0.418
TP53TG3B	0.418
GOLGA6L6	0.418
TP53TG3	0.417
TBC1D3I	0.417
TBC1D3L	0.417
TBC1D3K	0.417
TBC1D3E	0.417
PSMC1	0.416
HIST2H3A	0.416
TP53TG3C	0.416
PSMC2	0.416
HIST2H3C	0.416
SMG1	0.415
ATP13A1	0.415
C1QTNF9B	0.414
CWC22	0.414
PSMD11	0.414
MT1E	0.413
RPS7	0.413
COL2A1	0.413
CKAP5	0.412
PBXIP1	0.412
ARCN1	0.412
MADCAM1	0.411
CDC45	0.411
RBM39	0.411
SEC13	0.411
NDC80	0.41
MYT1L	0.41
CDCA3	0.409
PSMB1	0.409
UQCRH	0.408
CCDC64B	0.408
TSPY1	0.407
PAN2	0.407
TBC1D3	0.406
HEATR1	0.405
SLC4A1	0.405
PPFIA4	0.404
NUP85	0.404
RBBP5	0.404
WDR43	0.403
TPX2	0.403
WDR75	0.403
FAM231C	0.401
RPL38	0.401
FAM231A	0.401
ZNF106	0.4
EXOSC6	0.4
RPS19BP1	0.4
SMG7	0.4
ORC6	0.4

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 1793
Expression level (log2 read counts): -6.6

Expression Distribution