OTUD5

Entrez Summary: N/A
UniProt Summary: Deubiquitinating enzyme that functions as negative regulator of the innate immune system. Acts via TRAF3 deubiquitination and subsequent suppression of type I interferon (IFN) production. Has peptidase activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Can also cleave 'Lys-11'- linked ubiquitin chains (in vitro). {ECO:0000269|PubMed:17991829, ECO:0000269|PubMed:22245969, ECO:0000269|PubMed:23827681}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Disulfiram 4.3μM R06 exp281	-2.39
Tubastatin-A 2.5μM R07 exp417	-2.22
HMS-I2 10μM R06 exp288	-2.17
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	-2
Hypoxia 5%O2 R04 exp191	-1.9
THZ531 0.11μM R07 exp409	-1.89
Rapamycin 2μM R07 exp306	-1.82
Dimethyloxaloylglycine 100μM R05 exp229	-1.81
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	-1.72
UMK57 1μM R01 exp59	1.72
BVD-523 15μM R02 exp67	1.73
Oligomycin-A 20μM R00 exp26	1.73
Bleomycin 5μM R08 exp459	1.98
Rotenone 2μM R00 exp33	2.08
Actinomycin-D 0.001μM R00 exp3	2.26
Taxol 0.004μM R03 exp103	2.34
Etoposide 1μM R00 exp19	2.36
42°C R08 exp539	2.37
Pimelic-diphenylamide-106 5μM R00 exp28	2.63
BML-284 0.09μM R08 exp460	2.66
Actinomycin-D 0.01μM R00 exp4	2.81
5-Fluorouracil 20μM R00 exp2	2.87
MLN-4924 2μM R00 exp22	3.11
UM131593 0.2μM R03 exp106	3.38

Global Fraction of Cell Lines Where Essential: 42/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	1/1
bile duct	2/28
blood	0/26
bone	3/26
breast	3/30
central nervous system	1/49
cervix	0/4
colorectal	1/17
esophagus	1/11
fibroblast	0/1
gastric	1/14
kidney	2/18
liver	2/19
lung	2/72
lymphocyte	0/16
ovary	2/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	2/12
prostate	1/1
skin	2/20
soft tissue	0/9
thyroid	1/2
upper aerodigestive	4/22
urinary tract	0/28
uterus	1/5

Expression Distribution