BYSL

Gene Information

Official Symbol: BYSL
Official Name: bystin like
Aliases and Previous Symbols: N/A
Entrez ID: 705
UniProt: Q13895
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos. {ECO:0000269|PubMed:17360433, ECO:0000269|PubMed:17381424}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Bleomycin 5μM R08 exp459	-1.86
L-74142 5μM R03 exp131	1.73
MSC2530818 10μM R07 exp379	1.77
Zebularine 20μM R07 exp423	1.85
Tubastatin-A 2.5μM R07 exp417	1.86
ABT-702 5μM R07 exp318	1.88
Wiskostatin 3μM R07 exp422	1.91
HMS-I2 5μM R06 exp287	2.18
CHIR-124 0.04μM R06 exp272	2.19
Citral 50μM R06 exp274	2.2
FK-506 5μM R07 exp358	2.24
Geldanamycin 0.01μM R05 exp235	2.29
Glyphosate 1000μM R06 exp283	3.11

Gene	Correlation
CBWD6	0.548
CBWD5	0.546
TCEB3CL2	0.538
CBWD3	0.536
LRR1	0.517
PSMB4	0.516
TCEB3C	0.514
GOLGA6L4	0.514
KCTD17	0.506
RPL35	0.504
TCEB3CL	0.503
GOLGA6L3	0.496
SF3A1	0.49
GOLGA8J	0.489
PSMB2	0.488
RBBP5	0.486
RPS3A	0.483
IGFN1	0.482
CCNA2	0.482
C14orf93	0.48
PWP2	0.48
PSMB1	0.479
RPS2	0.476
RPS5	0.475
TYMS	0.474
TSPY8	0.473
NPIPB5	0.472
RPS11	0.471
PSMA7	0.471
PCF11	0.47
NOL10	0.469
RPS12	0.468
PSMD2	0.467
TBC1D3I	0.466
TBC1D3L	0.466
TBC1D3F	0.466
TBC1D3E	0.466
TBC1D3G	0.466
TBC1D3K	0.466
COPG1	0.466
TBC1D3	0.465
RRP7A	0.465
TBC1D3H	0.465
CHD4	0.464
HGC6.3	0.461
PSMD3	0.459
RPS19	0.459
COPB2	0.456
ORC6	0.456
EXOSC4	0.455
HIST2H3A	0.455
HIST2H3C	0.455
SLC38A7	0.454
ORC1	0.454
POLA1	0.453
ANKLE2	0.451
SF3A3	0.451
DDTL	0.451
MT1E	0.45
VASN	0.447
TFIP11	0.447
RPS7	0.446
BRIX1	0.445
EXOSC9	0.443
POLE	0.442
SSH2	0.441
SUPT5H	0.44
GOLGA6L1	0.44
RRP15	0.439
GOLGA8O	0.439
KRT78	0.438
WDR75	0.438
CDC6	0.438
ATP6V1C1	0.438
NUPL1	0.437
NUP133	0.436
AQR	0.435
CDCA5	0.434
TICRR	0.434
NGDN	0.43
CCDC116	0.43
PLK4	0.43
IK	0.429
MYO1H	0.428
PSMD1	0.427
GOLGA6L6	0.427
TWISTNB	0.427
DDX56	0.426
RRP9	0.425
TBC1D3C	0.425
RRP12	0.424
UTP20	0.423
PHF2	0.421
CEP192	0.419
NBPF10	0.419
FAM231C	0.418
FAM231A	0.418
PSMD11	0.418
PSMD14	0.418
MDM2	0.417
TERF1	0.417
SART1	0.417
WDR46	0.416
POLR2F	0.416
RPL6	0.416
CASC3	0.416
ARCN1	0.416
CACTIN	0.415
ATP6AP1	0.414
PSMA6	0.414
ELMOD3	0.413
EBNA1BP2	0.413
RNF113A	0.412
LIPE	0.412
MYB	0.411
PDE4DIP	0.411
RPS9	0.411
RPL34	0.41
INCENP	0.41
AKIRIN2	0.409
POLR2J3	0.408
DISP2	0.407
DDX21	0.407
RILPL1	0.407
GOLGA8K	0.406
SULT1A4	0.406
SULT1A3	0.406
TSR1	0.405
SLC6A17	0.405
POLA2	0.405
ZNF830	0.404
XAB2	0.404
C1QTNF9B	0.403
PLEKHA4	0.402
ADRM1	0.402
POLR2H	0.402
RPL9	0.402
CGB2	0.4
DNTTIP2	0.4
RAD21	0.4
ATP6V0C	0.4

Global Fraction of Cell Lines Where Essential: 705/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	25/28
blood	28/28
bone	25/26
breast	29/33
central nervous system	53/56
cervix	4/4
colorectal	15/17
esophagus	13/13
fibroblast	0/1
gastric	16/16
kidney	18/21
liver	19/20
lung	73/75
lymphocyte	14/16
ovary	24/26
pancreas	23/24
peripheral nervous system	16/16
plasma cell	15/15
prostate	1/1
skin	24/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	21/22
urinary tract	26/29
uterus	5/5

Essentiality in NALM6

Essentiality Rank: 950
Expression level (log2 read counts): 5.95

Expression Distribution