EIF4A1
Gene Information
- Official Symbol: EIF4A1
- Official Name: eukaryotic translation initiation factor 4A1
- Aliases and Previous Symbols: N/A
- Entrez ID: 1973
- UniProt: P60842
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. {ECO:0000269|PubMed:19153607, ECO:0000269|PubMed:19204291}.
Pfam Domains GO Terms
Pfam Domains
| DEAD |
| Helicase C |
GO Terms
| RNA cap binding |
| eukaryotic translation initiation factor 4F complex |
| translation factor activity, RNA binding |
| cytoplasmic translational initiation |
| helicase activity |
| translation initiation factor activity |
| RNA helicase activity |
| double-stranded RNA binding |
| cytoplasmic translation |
| translational initiation |
| mRNA binding |
| translation |
| peptide biosynthetic process |
| amide biosynthetic process |
| peptide metabolic process |
| viral process |
| symbiotic process |
| cellular amide metabolic process |
| interspecies interaction between organisms |
| RNA binding |
| organonitrogen compound biosynthetic process |
| ATP binding |
| cellular nitrogen compound biosynthetic process |
| cellular macromolecule biosynthetic process |
| macromolecule biosynthetic process |
| membrane |
| gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 679/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 1/1 |
| bile duct | 26/28 |
| blood | 27/28 |
| bone | 24/26 |
| breast | 30/33 |
| central nervous system | 51/56 |
| cervix | 4/4 |
| colorectal | 16/17 |
| esophagus | 11/13 |
| fibroblast | 0/1 |
| gastric | 16/16 |
| kidney | 20/21 |
| liver | 20/20 |
| lung | 68/75 |
| lymphocyte | 16/16 |
| ovary | 20/26 |
| pancreas | 24/24 |
| peripheral nervous system | 15/16 |
| plasma cell | 14/15 |
| prostate | 0/1 |
| skin | 23/24 |
| soft tissue | 9/9 |
| thyroid | 2/2 |
| upper aerodigestive | 17/22 |
| urinary tract | 27/29 |
| uterus | 5/5 |
Essentiality in NALM6
- Essentiality Rank: 2493
- Expression level (log2 read counts): 9.3
Expression Distribution
EIF4A1 Expression in NALM6 Cells: 9.3
