MARS
Gene Information
- Official Symbol: MARS1
- Official Name: methionyl-tRNA synthetase 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 4141
- UniProt: P56192
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. {ECO:0000269|PubMed:11714285}.
Pfam Domains GO Terms
Pfam Domains
| WHEP-TRS |
| tRNA-synt 1g |
GO Terms
| methionyl-tRNA aminoacylation |
| methionine-tRNA ligase activity |
| positive regulation of transcription of nucleolar large rRNA by RNA polymerase I |
| aminoacyl-tRNA synthetase multienzyme complex |
| regulation of transcription of nucleolar large rRNA by RNA polymerase I |
| cellular response to platelet-derived growth factor stimulus |
| response to platelet-derived growth factor |
| rRNA transcription |
| positive regulation of transcription by RNA polymerase I |
| regulation of transcription by RNA polymerase I |
| cellular response to epidermal growth factor stimulus |
| tRNA aminoacylation for protein translation |
| response to epidermal growth factor |
| tRNA aminoacylation |
| amino acid activation |
| tRNA binding |
| ncRNA transcription |
| cellular response to starvation |
| cellular response to insulin stimulus |
| tRNA metabolic process |
| response to starvation |
| response to insulin |
| cellular response to nutrient levels |
| cellular response to extracellular stimulus |
| cellular response to peptide hormone stimulus |
| cellular amino acid metabolic process |
| cellular response to peptide |
| cellular response to external stimulus |
| translation |
| response to peptide hormone |
| peptide biosynthetic process |
| response to peptide |
| ncRNA metabolic process |
| response to nutrient levels |
| cellular response to growth factor stimulus |
| amide biosynthetic process |
| peptide metabolic process |
| response to extracellular stimulus |
| response to growth factor |
| cellular response to organonitrogen compound |
| cellular response to hormone stimulus |
| transcription, DNA-templated |
| nucleic acid-templated transcription |
| RNA biosynthetic process |
| cellular response to nitrogen compound |
| cellular amide metabolic process |
| nucleolus |
| carboxylic acid metabolic process |
| response to hormone |
| response to organonitrogen compound |
| oxoacid metabolic process |
| organic acid metabolic process |
| cellular response to oxygen-containing compound |
| response to nitrogen compound |
| nucleobase-containing compound biosynthetic process |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| cellular response to endogenous stimulus |
| organic cyclic compound biosynthetic process |
| organonitrogen compound biosynthetic process |
| response to endogenous stimulus |
| ATP binding |
| positive regulation of transcription, DNA-templated |
| response to oxygen-containing compound |
| cellular nitrogen compound biosynthetic process |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| RNA metabolic process |
| cellular response to stress |
| cellular macromolecule biosynthetic process |
| positive regulation of RNA metabolic process |
| small molecule metabolic process |
| macromolecule biosynthetic process |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| membrane |
| gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| HARS | 0.691 |
| YARS | 0.585 |
| GMPPB | 0.58 |
| HSPD1 | 0.571 |
| SRP72 | 0.564 |
| RNMT | 0.563 |
| CARS | 0.557 |
| NARS | 0.557 |
| GFPT1 | 0.531 |
| EPRS | 0.529 |
| CCT7 | 0.529 |
| TTI2 | 0.521 |
| NSMCE1 | 0.515 |
| RBM14 | 0.506 |
| RPTOR | 0.503 |
| TBCA | 0.502 |
| CEP350 | 0.499 |
| PMM2 | 0.499 |
| AARS | 0.49 |
| CSNK2B | 0.489 |
| MTOR | 0.48 |
| SRP19 | 0.48 |
| RTCB | 0.477 |
| TBP | 0.477 |
| GTF3C3 | 0.475 |
| POLR3B | 0.474 |
| PMPCB | 0.473 |
| TBCD | 0.473 |
| SLC35B1 | 0.47 |
| SEH1L | 0.468 |
| PELO | 0.467 |
| TGS1 | 0.465 |
| GNB1L | 0.465 |
| ENO1 | 0.463 |
| UAP1 | 0.46 |
| SPCS2 | 0.459 |
| SPCS3 | 0.458 |
| EIF4E | 0.458 |
| VRK1 | 0.455 |
| MEAF6 | 0.452 |
| ALG13 | 0.45 |
| IARS | 0.448 |
| ZNHIT1 | 0.446 |
| TELO2 | 0.445 |
| GTF3C2 | 0.445 |
| SRPR | 0.443 |
| ALG5 | 0.441 |
| GTF3C6 | 0.44 |
| ENY2 | 0.438 |
| DPAGT1 | 0.437 |
| ORAOV1 | 0.436 |
| DDOST | 0.433 |
| SNF8 | 0.433 |
| HMGB2 | 0.432 |
| GTF3A | 0.431 |
| KARS | 0.43 |
| SRP68 | 0.427 |
| ZNF608 | 0.427 |
| PSMG4 | 0.427 |
| POLR3H | 0.427 |
| HAUS8 | 0.426 |
| ZNF259 | 0.426 |
| OIP5 | 0.426 |
| GEMIN5 | 0.423 |
| UBA3 | 0.423 |
| THOC3 | 0.423 |
| ABCF1 | 0.422 |
| ALG14 | 0.42 |
| PAM16 | 0.419 |
| OTUD5 | 0.419 |
| TRIAP1 | 0.415 |
| WDR24 | 0.414 |
| DAD1 | 0.414 |
| PISD | 0.413 |
| GEMIN8 | 0.411 |
| THG1L | 0.41 |
| DDX20 | 0.41 |
| CRCP | 0.41 |
| MAD2L1 | 0.409 |
| GPN2 | 0.409 |
| DPF2 | 0.406 |
| DDX55 | 0.406 |
| ALG1 | 0.403 |
| UTP23 | 0.403 |
| CCT5 | 0.403 |
| WARS | 0.402 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 708/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 1/1 |
| bile duct | 28/28 |
| blood | 27/28 |
| bone | 25/26 |
| breast | 31/33 |
| central nervous system | 53/56 |
| cervix | 4/4 |
| colorectal | 16/17 |
| esophagus | 13/13 |
| fibroblast | 1/1 |
| gastric | 16/16 |
| kidney | 17/21 |
| liver | 20/20 |
| lung | 73/75 |
| lymphocyte | 16/16 |
| ovary | 25/26 |
| pancreas | 23/24 |
| peripheral nervous system | 16/16 |
| plasma cell | 14/15 |
| prostate | 1/1 |
| skin | 24/24 |
| soft tissue | 9/9 |
| thyroid | 2/2 |
| upper aerodigestive | 20/22 |
| urinary tract | 25/29 |
| uterus | 4/5 |
Essentiality in NALM6
- Essentiality Rank: 11
- Expression level (log2 read counts): 7.95
Expression Distribution
MARS Expression in NALM6 Cells: 7.95
