NDUFS5

Gene Information

Official Symbol: NDUFS5
Official Name: N/ADH:ubiquinone oxidoreductase subunit S5
Aliases and Previous Symbols: N/A
Entrez ID: 4725
UniProt: O43920
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene is a member of the NADH dehydrogenase (ubiquinone) iron-sulfur protein family. The encoded protein is a subunit of the NADH:ubiquinone oxidoreductase (complex I), the first enzyme complex in the electron transport chain located in the inner mitochondrial membrane. Alternative splicing results in multiple transcript variants and pseudogenes have been identified on chromosomes 1, 4 and 17. [provided by RefSeq, May 2010].
UniProt Summary: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. {ECO:0000269|PubMed:27626371}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
MKC9989 10μM R03 exp133	-2.17
CHIR-124 0.04μM R06 exp272	-1.77
Chloroquine 32μM R08 exp470	1.72
Bortezomib 0.05μM R00 exp7	1.75
Genistein 15μM R07 exp360	1.88
Azithromycin 100μM R08 exp452	1.91
Atovaquone 15μM R08 exp451	1.98
Chloramphenicol 20μM R00 exp13	2.01
UM0125461 0.74μM R02 exp84	2.02
Vemurafenib 6.6μM R02 exp89	2.04
Artemisinin 50μM R08 exp450	2.07
Thimerosal 0.85μM R08 exp529	2.26
Quercetin 20μM R08 exp517	2.33
HMS-I2 10μM R06 exp288	2.45
Calcium Ionophore 0.4μM R07 exp342	2.65
Oligomycin-A 2μM R00 exp25	3.8

Gene	Correlation
NDUFS2	0.663
NDUFA1	0.652
NDUFAF7	0.633
NDUFB11	0.619
NDUFAF6	0.617
TIMMDC1	0.609
NDUFA11	0.608
ACAD9	0.601
MTO1	0.592
NDUFAF3	0.589
GRSF1	0.582
NDUFA2	0.572
NDUFV1	0.571
MTRF1L	0.571
NDUFB9	0.566
NDUFA3	0.561
NDUFC2	0.552
NDUFC1	0.551
NDUFAF5	0.543
NDUFS7	0.535
LARS2	0.534
NDUFA6	0.531
TFB1M	0.53
NDUFS8	0.527
NUBPL	0.526
NDUFB7	0.518
NDUFV2	0.518
NDUFB6	0.518
ECSIT	0.517
NDUFA8	0.513
RTN4IP1	0.507
FASTKD2	0.506
RPUSD3	0.501
FTSJ2	0.5
NDUFAF4	0.497
CARS2	0.495
NDUFS1	0.485
PET117	0.485
NARS2	0.484
PREPL	0.483
NDUFB2	0.48
GTPBP10	0.479
METTL17	0.479
GFM1	0.478
FOXRED1	0.474
NDUFB10	0.474
NDUFA10	0.471
NDUFB4	0.468
NDUFA13	0.467
TOMM7	0.466
MRPS25	0.466
TEFM	0.465
GTPBP6	0.463
MALSU1	0.463
ATP5SL	0.463
MRPS27	0.46
GFM2	0.46
NDUFS3	0.456
MTERFD1	0.456
MRP63	0.454
NDUFAF1	0.453
WBSCR16	0.453
PNPT1	0.451
CHCHD1	0.451
QRSL1	0.448
NDUFA5	0.448
MRPL45	0.448
C1QBP	0.447
WARS2	0.445
RBFA	0.444
ERAL1	0.443
RMND1	0.443
PET112	0.442
NDUFB5	0.441
SLC31A1	0.439
COQ2	0.438
COQ7	0.436
DAP3	0.435
TMEM261	0.434
RNASEH1	0.434
PDE12	0.433
MARS2	0.432
GTPBP8	0.431
MTIF2	0.431
MTG1	0.424
C12orf65	0.423
MRPL21	0.422
MRPS21	0.421
MRPS18B	0.421
AARS2	0.42
IBA57	0.417
HSD17B10	0.417
SSBP1	0.416
DARS2	0.416
YARS2	0.415
VARS2	0.415
MRPS16	0.414
MRPL4	0.414
TSFM	0.41
MRPL44	0.41
TARS2	0.41
CLPP	0.409
BCS1L	0.406
POLG2	0.404
RPUSD4	0.403
SELRC1	0.402
TRIT1	0.401

Global Fraction of Cell Lines Where Essential: 231/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	11/28
blood	11/28
bone	8/26
breast	14/33
central nervous system	12/56
cervix	2/4
colorectal	7/17
esophagus	6/13
fibroblast	0/1
gastric	6/16
kidney	5/21
liver	10/20
lung	24/75
lymphocyte	3/16
ovary	5/26
pancreas	4/24
peripheral nervous system	8/16
plasma cell	2/15
prostate	1/1
skin	9/24
soft tissue	2/9
thyroid	0/2
upper aerodigestive	3/22
urinary tract	4/29
uterus	1/5

Essentiality in NALM6

Essentiality Rank: 864
Expression level (log2 read counts): 4.8

Expression Distribution