MARS

Entrez Summary: N/A
UniProt Summary: Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. {ECO:0000269|PubMed:11714285}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Geldanamycin 0.01μM R05 exp235	-2.23
Rifampicin 10μM R00 exp32	-2.04
GSK2606414 1μM R05 exp236	-1.86
UM131593 0.1μM R01 exp58	-1.86
GSK-J4 1μM R07 exp362	-1.85
Rapamycin 1μM R00 exp29	-1.8
INK128 0.2μM R02 exp70	-1.79
2-Methoxyestradiol 0.2μM R01 exp40	-1.71
Actinomycin-D 0.001μM R00 exp3	1.7
SNS-032 25μM R07 exp401	1.79
Pimelic-diphenylamide-106 5μM R00 exp28	1.82
MLN-4924 2μM R00 exp22	1.86
SGC0649 7μM R03 exp150	1.93
Brefeldin A 0.02μM R00 exp8	1.96
SB743921 0.001μM R05 exp244	2.03
Nocodazole 0.2μM R00 exp24	2.67
Actinomycin-D 0.01μM R00 exp4	2.76

Global Fraction of Cell Lines Where Essential: 708/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	28/28
blood	27/28
bone	25/26
breast	31/33
central nervous system	53/56
cervix	4/4
colorectal	16/17
esophagus	13/13
fibroblast	1/1
gastric	16/16
kidney	17/21
liver	20/20
lung	73/75
lymphocyte	16/16
ovary	25/26
pancreas	23/24
peripheral nervous system	16/16
plasma cell	14/15
prostate	1/1
skin	24/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	20/22
urinary tract	25/29
uterus	4/5

Expression Distribution

WHEP-TRS
tRNA-synt 1g

methionyl-tRNA aminoacylation
methionine-tRNA ligase activity
positive regulation of transcription of nucleolar large rRNA by RNA polymerase I
aminoacyl-tRNA synthetase multienzyme complex
regulation of transcription of nucleolar large rRNA by RNA polymerase I
cellular response to platelet-derived growth factor stimulus
response to platelet-derived growth factor
rRNA transcription
positive regulation of transcription by RNA polymerase I
regulation of transcription by RNA polymerase I
cellular response to epidermal growth factor stimulus
tRNA aminoacylation for protein translation
response to epidermal growth factor
tRNA aminoacylation
amino acid activation
tRNA binding
ncRNA transcription
cellular response to starvation
cellular response to insulin stimulus
tRNA metabolic process
response to starvation
response to insulin
cellular response to nutrient levels
cellular response to extracellular stimulus
cellular response to peptide hormone stimulus
cellular amino acid metabolic process
cellular response to peptide
cellular response to external stimulus
translation
response to peptide hormone
peptide biosynthetic process
response to peptide
ncRNA metabolic process
response to nutrient levels
cellular response to growth factor stimulus
amide biosynthetic process
peptide metabolic process
response to extracellular stimulus
response to growth factor
cellular response to organonitrogen compound