SB203580 25μM R03 exp149

Mechanism of Action

p38 MAP kinase inhibitor

  • Class / Subclass 1: Signal Transduction / Kinase Inhibitor
  • Class / Subclass 2: Proteostasis / Autophagy Inhibitor

Technical Notes

Compound References

  • PubChem Name: 4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazole
  • Synonyms: RWJ 64809
  • CAS #: 152121-47-6
  • PubChem CID: 176155
  • IUPAC: 4-[4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine
  • INCHI Name: InChI=1S/C21H16FN3OS/c1-27(26)18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15/h2-13H,1H3,(H,24,25)
  • INCHI Key: CDMGBJANTYXAIV-UHFFFAOYSA-N
  • Molecular Weight: 377.4
  • Canonical SMILES: CS(=O)C1=CC=C(C=C1)C2=NC(=C(N2)C3=CC=NC=C3)C4=CC=C(C=C4)F
  • Isomeric SMILES: N/A
  • Molecular Formula: C21H16FN3OS

Compound Supplier

  • Supplier Name: Selleck Chemicals
  • Catalog #: S1076
  • Lot #: 08

Compound Characterization

  • LCMS: Tr 1.10 min, m/z 378+ [M+H]+, 376- [M-H]-

Dose Response Curve

  • Platform ID: SB203580
  • Min: -0.3115; Max: 90.3000





IC Concentration (µM)
IC10 N/A
IC20 19.1742
IC30 22.4861
IC40 25.6234
IC50 28.8863
IC60 N/A
IC70 N/A
IC80 N/A
IC90 N/A


Screen Summary

  • Round: 03
  • Dose: 25µM
  • Days of incubation: 8
  • Doublings: 7.1
  • Numbers of reads: 11544089

Screen Results

Sensitive/Resistant hits (FDR<0.05)CRANKSScore PlotTop 30 GenesScreen SimilarityTop 30 Sensitive GO termsTop 30 Resistant GO terms
6/0ScoresViewViewViewViewView

  • Last modified: 2026/01/15 21:36
  • by 127.0.0.1