6-Thio-2-deoxyguanosine 2μM R06 exp259

Nucleoside analog, incorporated into telomeric DNA by telomerase, impairs proliferation of telomerase-positive cells

Class / Subclass 1: Metabolism / Antimetabolite
Class / Subclass 2: DNA Damage, Repair and Replication / Helix-Distorting Adduct

PubChem Name: 2'-Deoxythioguanosine
Synonyms: 6-thio-dG; β-TGdR; 6-thio-dG;β-TGdR
CAS #: 789-61-7
PubChem CID: 3000603
IUPAC: 2-amino-9-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H-purine-6-thione
INCHI Name: InChI=1S/C10H13N5O3S/c11-10-13-8-7(9(19)14-10)12-3-15(8)6-1-4(17)5(2-16)18-6/h3-6,16-17H,1-2H2,(H3,11,13,14,19)/t4-,5+,6+/m0/s1
INCHI Key: SCVJRXQHFJXZFZ-KVQBGUIXSA-N
Molecular Weight: 283.31
Canonical SMILES: C1C(C(OC1N2C=NC3=C2NC(=NC3=S)N)CO)O
Isomeric SMILES: C1[C@@H]([C@H](O[C@H]1N2C=NC3=C2NC(=NC3=S)N)CO)O
Molecular Formula: C10H13N5O3S

Dose response curve not available.

Sensitive/Resistant hits (FDR<0.05)	CRANKS	Score Plot	Top 30 Genes	Screen Similarity	Top 30 Sensitive GO terms	Top 30 Resistant GO terms
0/28	Scores	View	View	View	View	View

Screen	Correlation	Plot
Benzoate 20000μM R08 exp456	0.16	View
MS023 7μM R03 exp135	0.118	View
Bleomycin 5μM R08 exp459	0.109	View
Etoposide 0.3μM R05 exp199	0.109	View
CI-1040 9.5μM R08 exp472	0.101	View
RO-3307 4.7μM R02 exp80	0.099	View
UM0129480 7μM R02 exp85	0.097	View
Doxorubicin 0.02μM R08 exp478	0.096	View
THZ1 0.06μM R08 exp531	0.096	View
Mitomycin-C 0.06μM R08 exp503	0.086	View
Tanespimycin 14μM R08 exp527	0.084	View
Actinomycin-D 0.001μM R00 exp3	0.083	View
SNS-032 15μM R08 exp443	0.081	View
Hippuristanol 0.12μM R08 exp488	0.077	View
AICAR 240μM R05 exp211	0.076	View
Pimelic-diphenylamide-106 5μM R00 exp28	0.076	View
Dorsomorphin 5μM R07 exp357	0.076	View
Hippuristanol 0.12μM R08 exp489 no dilution day6	0.074	View
Olaparib 4μM R08 exp512	0.073	View
Rotenone 20μM R00 exp34	0.071	View
PU-H71 1μM R08 exp515	0.07	View
Artemisinin 50μM R08 exp450	0.069	View
MLN-4924 0.2μM R00 exp21	0.069	View
Aphidicolin 0.4μM R08 exp440	0.068	View
MS023 2μM R03 exp134	0.067	View
AICAR 240μM R03 exp116	0.063	View
Dinaciclib 0.007μM R07 exp355	0.062	View
Etoposide 1μM R00 exp19	0.062	View
Atovaquone 15μM R08 exp451	0.062	View
Vinblastine 0.2μM R03 exp108	0.062	View
Staurosporine 0.02μM R08 exp524	0.06	View
Ethanol 0.01 R05 exp234	0.057	View
GSK626616 14μM R08 exp485	0.056	View
JQ1 0.8μM R08 exp435	0.054	View
CB-5083 0.4μM R08 exp468	0.053	View
Milciclib 2μM R08 exp502	0.052	View
BI-2536 0.02μM R03 exp96	0.051	View
5-Fluorouracil 20μM R00 exp2	0.105	View
2-Deoxy-D-glucose 800μM R05 exp214	0.058	View

GO Term	Fold Change	Genes
DNA replication checkpoint signaling	108.31	ORC1,CDT1,TICRR
regulation of DNA replication	25.15	PPP2CA,CCNA2,CDT1,PPP2R1A,TICRR
mitotic cell cycle process	13.03	CKAP5,CCNA2,ORC1,CDT1,PRC1,PPP2R1A,FGF10,WEE1,TICRR,INCENP,POLA1
mitotic cell cycle	12.23	CKAP5,PPP2CA,CCNA2,ORC1,CDT1,PRC1,PPP2R1A,FGF10,WEE1,TICRR,INCENP,POLA1
regulation of mitotic cell cycle phase transition	11.40	PPP2CA,ORC1,FGF10,WEE1,TICRR,INCENP
regulation of cell cycle phase transition	10.33	PPP2CA,ORC1,CDT1,FGF10,WEE1,TICRR,INCENP
chromosomal region	9.90	CKAP5,PPP2CA,ORC1,CDT1,PPP2R1A,INCENP
cell division	8.47	CKAP5,MAU2,CCNA2,CDT1,PRC1,WEE1,INCENP
cell cycle process	8.43	CKAP5,MAU2,CCNA2,ORC1,CDT1,PRC1,PPP2R1A,FGF10,WEE1,TICRR,INCENP,POLA1
regulation of cell cycle process	7.97	PPP2CA,ORC1,CDT1,PRC1,PPP2R1A,FGF10,WEE1,TICRR,INCENP

GO Term	Fold Change	Genes
protein urmylation	368.27	CTU1,MOCS3
tRNA thio-modification	276.20	CTU1,MOCS3
tRNA wobble uridine modification	103.58	ELP3,CTU1,MOCS3
tRNA wobble base modification	87.22	ELP3,CTU1,MOCS3
tRNA modification	25.11	ELP3,CTU1,MOCS3,THG1L
nucleotidyltransferase activity	20.31	NUDT5,CTU1,MOCS3,THG1L,TUT1
tRNA metabolic process	17.92	ELP3,CTU1,QARS1,MOCS3,THG1L,GTF3C5
ncRNA metabolic process	8.79	ELP3,CTU1,QARS1,MOCS3,THG1L,TUT1,GTF3C5,RPS25
intracellular protein-containing complex	5.68	EIF4A1,KCTD5,RPTOR,ELP3,ENY2,CTU1,FBXO11,QARS1,UBQLN1