CASP9

Gene Information

Official Symbol: CASP9
Official Name: caspase 9
Aliases and Previous Symbols: N/A
Entrez ID: 842
UniProt: P55211
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein can undergo autoproteolytic processing and activation by the apoptosome, a protein complex of cytochrome c and the apoptotic peptidase activating factor 1; this step is thought to be one of the earliest in the caspase activation cascade. This protein is thought to play a central role in apoptosis and to be a tumor suppressor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]. COMPLETENESS: complete on the 3' end.
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
GSK-J4 1μM R07 exp362	-1.89
Deguelin 0.15μM R05 exp209	1.76
6-Thio-2-deoxyguanosine 2μM R06 exp259	1.78
Ethanol 0.01 R05 exp234	1.82
UM0129480 7μM R02 exp85	1.83
Tanespimycin 14μM R08 exp527	1.84
Diepoxybutane 3μM R07 exp354	1.91
Nutlin-3A 1.6μM R06 exp294	1.94
Bortezomib 0.05μM R00 exp7	1.97
Rotenone 2μM R00 exp33	2.08
Bleomycin 5μM R08 exp459	2.16
Atovaquone 15μM R08 exp451	2.29
Artemisinin 50μM R08 exp450	2.3
JQ1 0.8μM R08 exp435	2.32
CI-1040 9.5μM R08 exp472	2.41
AICAR 240μM R05 exp211	2.72
PU-H71 1μM R08 exp515	2.74
GSK-J4 1.5μM R08 exp441	2.75
MS023 2μM R03 exp134	2.81
Etoposide 1μM R00 exp19	2.86
Rotenone 20μM R00 exp34	2.87
AICAR 240μM R03 exp116	2.93
THZ1 0.06μM R08 exp531	2.97
Etoposide 0.3μM R05 exp199	3.09
Hippuristanol 0.12μM R08 exp488	3.2
Staurosporine 0.02μM R08 exp524	3.26
SNS-032 15μM R08 exp443	3.33
Olaparib 4μM R08 exp512	3.35
RO-3307 4.7μM R02 exp80	3.43
Aphidicolin 0.4μM R08 exp440	3.68
Benzoate 20000μM R08 exp456	3.7
Pimelic-diphenylamide-106 5μM R00 exp28	3.97
Hippuristanol 0.12μM R08 exp489 no dilution day6	4.25
5-Fluorouracil 20μM R00 exp2	4.44
CR131-b 0.005μM R08 exp474	4.44
Mitomycin-C 0.06μM R08 exp503	4.57
Doxorubicin 0.02μM R08 exp478	4.85
MS023 7μM R03 exp135	5.94
Actinomycin-D 0.001μM R00 exp3	5.97

Gene	Correlation
BAK1	0.799
APAF1	0.79
HCCS	0.752
MARCH5	0.751
CYCS	0.728
VDAC2	0.722
PLAA	0.718
UBQLN1	0.712
DIABLO	0.661
DOHH	0.656
SERF2	0.629
HSPD1	0.627
TRIAP1	0.596
ENY2	0.593
FAF2	0.591
THG1L	0.589
BAP1	0.581
RPTOR	0.57
METAP2	0.561
GFPT1	0.557
UAP1	0.552
ROMO1	0.55
MFN1	0.537
ATP5J	0.533
RAD23B	0.531
GMPPB	0.526
CSNK2B	0.525
ATAD1	0.524
STAU1	0.518
MEAF6	0.517
RNMT	0.517
GABPA	0.516
HARS	0.514
UBE2K	0.513
NXT1	0.503
PMM2	0.5
PPA2	0.5
NSD1	0.498
MTOR	0.495
DPAGT1	0.494
ZZZ3	0.489
CRLS1	0.488
OPA1	0.485
ALG1	0.481
RTCB	0.478
DHPS	0.477
WDR24	0.476
SLC25A26	0.475
TAZ	0.474
TIMM13	0.473
ATP5B	0.469
ATP5I	0.467
ALG2	0.465
PPP2R3C	0.464
ATP5O	0.464
MLST8	0.463
WDR59	0.463
UBE2G2	0.461
NUPL2	0.455
RPN1	0.453
ATP5A1	0.452
EXOC4	0.452
KDSR	0.45
FBXO11	0.448
PAM16	0.448
SRP14	0.447
CBFB	0.445
PDPK1	0.445
TAMM41	0.444
ORAOV1	0.444
THOC6	0.443
KCTD5	0.442
NAE1	0.441
VHL	0.441
ADSL	0.44
DDHD2	0.439
RPE	0.439
FECH	0.435
ABCF1	0.435
SRRD	0.434
UBA3	0.432
TRIM28	0.429
ELP3	0.427
CTDNEP1	0.426
ATXN10	0.424
CARS	0.422
DR1	0.419
PRKRIR	0.418
SUPV3L1	0.416
SSB	0.415
ALG5	0.415
LAMTOR4	0.415
DAD1	0.414
SEC61G	0.412
ATP5D	0.41
PELO	0.409
TBP	0.408
OIP5	0.407
VEZT	0.406
ATP5F1	0.406
MAPKAP1	0.405
SEC16A	0.405
LAMTOR5	0.404
PIK3R4	0.401
TRNT1	0.401
VRK1	0.401

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 6862
Expression level (log2 read counts): 3.49

Expression Distribution

CARD
Peptidase C14

apoptosome
glial cell apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
cysteine-type endopeptidase activity involved in apoptotic signaling pathway
response to cobalt ion
cysteine-type endopeptidase activity involved in apoptotic process
platelet formation
platelet morphogenesis
leukocyte apoptotic process
cellular response to dexamethasone stimulus
extrinsic apoptotic signaling pathway in absence of ligand
signal transduction in absence of ligand
response to dexamethasone
enzyme activator activity
response to ischemia
positive regulation of neuron apoptotic process
cellular response to glucocorticoid stimulus
cellular response to corticosteroid stimulus
intrinsic apoptotic signaling pathway in response to DNA damage
peptidase activity
cellular response to UV
activation of cysteine-type endopeptidase activity involved in apoptotic process
cellular response to ketone
cysteine-type endopeptidase activity
positive regulation of neuron death
response to antineoplastic agent
extrinsic apoptotic signaling pathway
signal transduction in response to DNA damage
cellular response to light stimulus
SH3 domain binding
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
response to estradiol
response to UV
response to glucocorticoid
intrinsic apoptotic signaling pathway
positive regulation of cysteine-type endopeptidase activity
response to corticosteroid
positive regulation of endopeptidase activity
cellular response to radiation
cellular response to xenobiotic stimulus