CCT7

Gene Information

Official Symbol: CCT7
Official Name: chaperonin containing TCP1 subunit 7
Aliases and Previous Symbols: N/A
Entrez ID: 10574
UniProt: Q99832
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 5 and 6. [provided by RefSeq, Oct 2009].
UniProt Summary: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Tubastatin-A 2.5μM R07 exp417	-1.96
NN-Diethyl-meta-toluamide 500μM R08 exp438	-1.77
Brefeldin A 0.02μM R00 exp8	1.73
Doxorubicin 0.02μM R08 exp478	1.73
SNS-032 15μM R08 exp443	1.76
NFN1 1μM R03 exp100	1.83
CI-1040 9.5μM R08 exp472	1.86
Rotenone 2μM R00 exp33	1.87
MLN-4924 2μM R00 exp22	1.9
Actinomycin-D 0.001μM R00 exp3	1.91
Amiloride 100μM R08 exp447	1.94
Rotenone 20μM R00 exp34	1.94
BVD-523 15μM R02 exp67	1.99
Pimelic-diphenylamide-106 5μM R00 exp28	2.43
Actinomycin-D 0.01μM R00 exp4	2.57
Etoposide 1μM R00 exp19	3.16

Gene	Correlation
HARS	0.71
NARS	0.59
RNMT	0.572
RTCB	0.572
RPTOR	0.564
HSPD1	0.563
VRK1	0.561
AARS	0.561
GMPPB	0.56
YARS	0.555
TELO2	0.531
MARS	0.529
GTF3C2	0.523
THG1L	0.521
TTI2	0.515
OTUD5	0.514
MEAF6	0.511
NAE1	0.503
GNB1L	0.503
GTF3C6	0.5
SEH1L	0.5
TRIAP1	0.498
EIF4E	0.497
MTOR	0.495
GTF3C3	0.491
SLC35B1	0.489
CSNK2B	0.489
DPAGT1	0.481
UHRF1	0.48
ALG1	0.478
EPRS	0.475
GFPT1	0.473
UAP1	0.47
TRMT5	0.47
TTI1	0.469
PMM2	0.466
TPRKB	0.466
ALG2	0.461
THOC3	0.461
ADSL	0.461
ENY2	0.46
SRP14	0.458
TLE4	0.457
GEMIN5	0.456
CCDC101	0.456
WDR24	0.454
RPE	0.454
ALG14	0.451
PPP4C	0.451
BAP1	0.449
ZRSR2	0.448
TAZ	0.447
MAPK14	0.447
ALG13	0.446
RBMX2	0.445
ATP5J	0.444
UTP23	0.444
HCCS	0.444
WARS	0.443
PLAA	0.442
CBFB	0.442
UBA3	0.441
PELO	0.438
ENO1	0.431
POLR3B	0.431
HAUS8	0.43
SRP68	0.429
CARS	0.427
EIF3F	0.427
SRP72	0.426
MED16	0.426
PSMG4	0.426
TGS1	0.422
UXT	0.422
VEZT	0.421
DDX20	0.421
RAD1	0.42
TAMM41	0.418
EXOC4	0.418
ATXN10	0.415
NUP50	0.413
ZNF259	0.41
RPP21	0.41
DKC1	0.41
TBCA	0.404
DHPS	0.404
DOHH	0.403
GEN1	0.402
LSM11	0.402
PIK3R4	0.4
SPCS3	0.4

Global Fraction of Cell Lines Where Essential: 12/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	1/26
breast	1/33
central nervous system	1/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	1/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	1/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 347
Expression level (log2 read counts): 8.61

Expression Distribution

regulation of protein localization to Cajal body
positive regulation of protein localization to Cajal body
positive regulation of establishment of protein localization to telomere
regulation of establishment of protein localization to telomere
chaperonin-containing T-complex
regulation of establishment of protein localization to chromosome
positive regulation of protein localization to chromosome, telomeric region
regulation of protein localization to chromosome, telomeric region
positive regulation of telomerase RNA localization to Cajal body
regulation of telomerase RNA localization to Cajal body
positive regulation of telomere maintenance via telomerase
binding of sperm to zona pellucida
positive regulation of telomere maintenance via telomere lengthening
toxin transport
positive regulation of telomere maintenance
sperm-egg recognition
regulation of telomere maintenance via telomerase
regulation of telomere maintenance via telomere lengthening
positive regulation of DNA biosynthetic process
cell-cell recognition
cell body
positive regulation of protein localization to nucleus
regulation of telomere maintenance
regulation of DNA biosynthetic process
regulation of protein localization to nucleus
unfolded protein binding
single fertilization
fertilization
positive regulation of chromosome organization
protein stabilization
positive regulation of DNA metabolic process
protein folding
cell recognition
regulation of protein stability
microtubule
positive regulation of cellular protein localization
regulation of chromosome organization
regulation of DNA metabolic process
positive regulation of establishment of protein localization
regulation of cellular protein localization