COX11

Entrez Summary: N/A
UniProt Summary: Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 13/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	2/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	2/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	1/21
liver	0/20
lung	1/75
lymphocyte	1/16
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	2/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	1/29
uterus	0/5

Expression Distribution

negative regulation of glucokinase activity
negative regulation of hexokinase activity
regulation of glucokinase activity
regulation of hexokinase activity
integral component of mitochondrial inner membrane
negative regulation of cellular carbohydrate metabolic process
negative regulation of carbohydrate metabolic process
copper ion binding
electron transfer activity
regulation of glucose metabolic process
regulation of cellular carbohydrate metabolic process
electron transport chain
regulation of carbohydrate metabolic process
negative regulation of kinase activity
negative regulation of transferase activity
generation of precursor metabolites and energy
regulation of small molecule metabolic process
negative regulation of phosphorylation
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
protein-containing complex
metal ion homeostasis
cation homeostasis
inorganic ion homeostasis
ion homeostasis
negative regulation of catalytic activity
regulation of kinase activity
oxidation-reduction process
regulation of transferase activity
chemical homeostasis
negative regulation of molecular function
mitochondrion
regulation of phosphorylation
homeostatic process
regulation of phosphate metabolic process
regulation of phosphorus metabolic process