EPRS
Gene Information
- Official Symbol: EPRS1
- Official Name: glutamyl-prolyl-tRNA synthetase 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 2058
- UniProt: P07814
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| WHEP-TRS |
| tRNA-synt 2b |
| tRNA-synt 1c |
| tRNA-synt 1c C |
| ProRS-C 1 |
| HGTP anticodon |
GO Terms
| proline-tRNA ligase activity |
| prolyl-tRNA aminoacylation |
| glutamate-tRNA ligase activity |
| glutamyl-tRNA aminoacylation |
| GAIT complex |
| regulation of long-chain fatty acid import into cell |
| long-chain fatty acid import into cell |
| lipid import into cell |
| aminoacyl-tRNA synthetase multienzyme complex |
| RNA stem-loop binding |
| regulation of fatty acid transport |
| GTPase binding |
| tRNA aminoacylation for protein translation |
| tRNA aminoacylation |
| amino acid activation |
| regulation of organic acid transport |
| long-chain fatty acid transport |
| fatty acid transport |
| regulation of anion transport |
| regulation of lipid transport |
| negative regulation of translation |
| monocarboxylic acid transport |
| regulation of lipid localization |
| negative regulation of cellular amide metabolic process |
| ribonucleoprotein complex |
| cellular response to interferon-gamma |
| cellular response to insulin stimulus |
| response to interferon-gamma |
| tRNA metabolic process |
| response to insulin |
| cellular response to peptide hormone stimulus |
| organic acid transport |
| carboxylic acid transport |
| lipid transport |
| cellular amino acid metabolic process |
| lipid localization |
| cellular response to peptide |
| regulation of translation |
| translation |
| response to peptide hormone |
| regulation of cellular amide metabolic process |
| peptide biosynthetic process |
| organic anion transport |
| response to peptide |
| ncRNA metabolic process |
| posttranscriptional regulation of gene expression |
| amide biosynthetic process |
| peptide metabolic process |
| anion transport |
| cellular response to organonitrogen compound |
| cellular response to hormone stimulus |
| cellular response to nitrogen compound |
| import into cell |
| regulation of ion transport |
| innate immune response |
| cellular amide metabolic process |
| zinc ion binding |
| protein homodimerization activity |
| carboxylic acid metabolic process |
| response to hormone |
| defense response to other organism |
| response to organonitrogen compound |
| oxoacid metabolic process |
| cellular response to cytokine stimulus |
| organic acid metabolic process |
| negative regulation of cellular protein metabolic process |
| cellular response to oxygen-containing compound |
| identical protein binding |
| response to nitrogen compound |
| response to cytokine |
| negative regulation of protein metabolic process |
| cellular response to endogenous stimulus |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| defense response |
| ion transport |
| negative regulation of cellular macromolecule biosynthetic process |
| organonitrogen compound biosynthetic process |
| negative regulation of macromolecule biosynthetic process |
| response to endogenous stimulus |
| ATP binding |
| negative regulation of cellular biosynthetic process |
| negative regulation of biosynthetic process |
| response to oxygen-containing compound |
| protein-containing complex assembly |
| cellular nitrogen compound biosynthetic process |
| RNA metabolic process |
| cellular macromolecule biosynthetic process |
| negative regulation of gene expression |
| small molecule metabolic process |
| macromolecule biosynthetic process |
| protein-containing complex subunit organization |
| regulation of transport |
| immune response |
| membrane |
| gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| GMPPB | 0.609 |
| RNMT | 0.565 |
| PMM2 | 0.553 |
| HARS | 0.551 |
| SPCS2 | 0.543 |
| MARS | 0.529 |
| RPTOR | 0.526 |
| ADSL | 0.523 |
| TTI2 | 0.522 |
| DPAGT1 | 0.522 |
| OSGEP | 0.522 |
| RTCB | 0.52 |
| RPP21 | 0.52 |
| AARS | 0.514 |
| NARS | 0.51 |
| DCTN6 | 0.51 |
| TTI1 | 0.509 |
| THG1L | 0.508 |
| NAE1 | 0.507 |
| PELO | 0.5 |
| ALG2 | 0.498 |
| GNB1L | 0.498 |
| DDOST | 0.496 |
| ALG14 | 0.496 |
| GTF3C2 | 0.495 |
| TSEN2 | 0.494 |
| PAM16 | 0.493 |
| CSNK2B | 0.492 |
| VRK1 | 0.492 |
| TBCA | 0.49 |
| EXOC4 | 0.489 |
| SNF8 | 0.487 |
| GTF3C3 | 0.484 |
| EXOC3 | 0.483 |
| ALG1 | 0.482 |
| MED16 | 0.481 |
| SRP14 | 0.479 |
| CCDC101 | 0.477 |
| ATXN10 | 0.476 |
| CCT7 | 0.475 |
| DDX20 | 0.475 |
| DAD1 | 0.472 |
| DHPS | 0.472 |
| SEH1L | 0.466 |
| YARS | 0.464 |
| TBCD | 0.464 |
| ENY2 | 0.463 |
| HSPD1 | 0.463 |
| UXT | 0.458 |
| RPE | 0.458 |
| RPN1 | 0.457 |
| EIF4E | 0.456 |
| GEMIN8 | 0.454 |
| MED4 | 0.454 |
| PAX5 | 0.453 |
| MTOR | 0.452 |
| UAP1 | 0.45 |
| UHRF1 | 0.45 |
| GFPT1 | 0.45 |
| IARS2 | 0.448 |
| GEMIN5 | 0.448 |
| RBM14 | 0.448 |
| CEP350 | 0.444 |
| TRIAP1 | 0.443 |
| ALG13 | 0.442 |
| THOC3 | 0.441 |
| TELO2 | 0.44 |
| UTP23 | 0.438 |
| NSMCE1 | 0.435 |
| DOHH | 0.432 |
| RABGGTB | 0.431 |
| WDR24 | 0.431 |
| CARS | 0.431 |
| VEZT | 0.43 |
| GEMIN6 | 0.428 |
| TPRKB | 0.425 |
| PISD | 0.425 |
| TRMT5 | 0.424 |
| TIMM13 | 0.424 |
| CEP57 | 0.423 |
| POLR3H | 0.422 |
| ZNF259 | 0.42 |
| PPP2R3C | 0.413 |
| TSEN54 | 0.413 |
| EIF3F | 0.413 |
| TSEN34 | 0.407 |
| HAUS8 | 0.406 |
| SRP68 | 0.405 |
| POLR3B | 0.404 |
| QARS | 0.403 |
| ACTR10 | 0.403 |
| PPP4C | 0.402 |
| MLLT1 | 0.401 |
| BAP1 | 0.401 |
| SNAPC5 | 0.4 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 651/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 1/1 |
| bile duct | 23/28 |
| blood | 23/28 |
| bone | 24/26 |
| breast | 27/33 |
| central nervous system | 50/56 |
| cervix | 4/4 |
| colorectal | 15/17 |
| esophagus | 12/13 |
| fibroblast | 1/1 |
| gastric | 16/16 |
| kidney | 16/21 |
| liver | 17/20 |
| lung | 65/75 |
| lymphocyte | 10/16 |
| ovary | 25/26 |
| pancreas | 22/24 |
| peripheral nervous system | 16/16 |
| plasma cell | 10/15 |
| prostate | 1/1 |
| skin | 19/24 |
| soft tissue | 8/9 |
| thyroid | 2/2 |
| upper aerodigestive | 22/22 |
| urinary tract | 27/29 |
| uterus | 3/5 |
Essentiality in NALM6
- Essentiality Rank: 896
- Expression level (log2 read counts): 8.71
Expression Distribution
EPRS Expression in NALM6 Cells: 8.71
