LSM11
Gene Information
- Official Symbol: LSM11
- Official Name: LSM11, U7 small nuclear RNA associated
- Aliases and Previous Symbols: N/A
- Entrez ID: 134353
- UniProt: P83369
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| LSM |
GO Terms
| U7 snRNA binding |
| mRNA 3-end processing by stem-loop binding and cleavage |
| histone pre-mRNA 3end processing complex |
| U7 snRNP |
| telomerase holoenzyme complex |
| histone mRNA metabolic process |
| termination of RNA polymerase II transcription |
| positive regulation of G1/S transition of mitotic cell cycle |
| positive regulation of cell cycle G1/S phase transition |
| DNA-templated transcription, termination |
| positive regulation of mitotic cell cycle phase transition |
| mRNA 3-end processing |
| positive regulation of cell cycle phase transition |
| RNA 3-end processing |
| regulation of G1/S transition of mitotic cell cycle |
| positive regulation of mitotic cell cycle |
| regulation of cell cycle G1/S phase transition |
| nuclear body |
| positive regulation of cell cycle process |
| positive regulation of cell cycle |
| regulation of mitotic cell cycle phase transition |
| regulation of cell cycle phase transition |
| mRNA processing |
| transcription by RNA polymerase II |
| regulation of mitotic cell cycle |
| transcription, DNA-templated |
| nucleic acid-templated transcription |
| RNA biosynthetic process |
| mRNA metabolic process |
| regulation of cell cycle process |
| RNA processing |
| nucleobase-containing compound biosynthetic process |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| regulation of cell cycle |
| organic cyclic compound biosynthetic process |
| cellular nitrogen compound biosynthetic process |
| RNA metabolic process |
| cellular macromolecule biosynthetic process |
| macromolecule biosynthetic process |
| gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Aphidicolin 0.04μM R06 exp263 | -2.18 |
| CCCP 1μM R00 exp11 | -1.96 |
| B02 10μM R08 exp453 | -1.86 |
| ∆-9-Tetrahydrocannabinol 30μM R08 exp445 | 1.92 |
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| THG1L | 0.567 |
| RPTOR | 0.562 |
| UAP1 | 0.542 |
| DOHH | 0.541 |
| GMPPB | 0.536 |
| EXOC4 | 0.528 |
| ATXN10 | 0.519 |
| PMM2 | 0.514 |
| CBFB | 0.511 |
| UHRF1 | 0.509 |
| DPAGT1 | 0.504 |
| RTCB | 0.498 |
| GNB1L | 0.491 |
| RNMT | 0.485 |
| GTF3C6 | 0.484 |
| ATP5J | 0.477 |
| GFPT1 | 0.471 |
| SRP14 | 0.469 |
| RPP21 | 0.464 |
| TMEM41B | 0.461 |
| PPCS | 0.459 |
| URM1 | 0.459 |
| PELO | 0.458 |
| PPA2 | 0.458 |
| TEN1 | 0.458 |
| ALG1 | 0.456 |
| ALG13 | 0.454 |
| ALG2 | 0.454 |
| TRIAP1 | 0.454 |
| PPP6C | 0.453 |
| MTOR | 0.452 |
| WDR59 | 0.449 |
| TTI2 | 0.446 |
| NARS | 0.445 |
| TTI1 | 0.444 |
| TAMM41 | 0.443 |
| GTF3C3 | 0.442 |
| TTC4 | 0.441 |
| ELAC2 | 0.44 |
| HARS | 0.439 |
| FH | 0.439 |
| MED16 | 0.438 |
| EIF3F | 0.436 |
| LMO2 | 0.435 |
| DHPS | 0.434 |
| QARS | 0.434 |
| ADSL | 0.433 |
| ELP2 | 0.432 |
| UBE2G2 | 0.43 |
| TRMT10A | 0.429 |
| SSB | 0.429 |
| TAZ | 0.427 |
| KIAA0391 | 0.427 |
| N6AMT1 | 0.426 |
| HAUS8 | 0.424 |
| WDR24 | 0.423 |
| GTF3C4 | 0.423 |
| VEZT | 0.423 |
| DPF2 | 0.421 |
| ATP5A1 | 0.419 |
| DDX1 | 0.419 |
| SLC25A26 | 0.418 |
| DR1 | 0.416 |
| CCDC101 | 0.416 |
| CHCHD4 | 0.416 |
| YARS | 0.416 |
| MAPK14 | 0.414 |
| MED23 | 0.414 |
| TSEN34 | 0.414 |
| DDX20 | 0.412 |
| LSM10 | 0.412 |
| GEMIN8 | 0.412 |
| MLLT1 | 0.411 |
| DHRSX | 0.409 |
| SEC62 | 0.409 |
| ID3 | 0.409 |
| MAML1 | 0.405 |
| SLC25A19 | 0.405 |
| EXOC3 | 0.403 |
| ZNF608 | 0.402 |
| PDAP1 | 0.402 |
| CCT7 | 0.402 |
| TRNT1 | 0.401 |
| MBTPS2 | 0.401 |
| RFT1 | 0.401 |
| UTP23 | 0.4 |
| SNAPC5 | 0.4 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 49/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 1/28 |
| blood | 0/28 |
| bone | 3/25 |
| breast | 3/33 |
| central nervous system | 5/56 |
| cervix | 0/4 |
| colorectal | 1/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/15 |
| kidney | 0/21 |
| liver | 1/20 |
| lung | 6/75 |
| lymphocyte | 0/14 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 1/16 |
| plasma cell | 1/15 |
| prostate | 0/1 |
| skin | 1/24 |
| soft tissue | 1/7 |
| thyroid | 0/2 |
| upper aerodigestive | 1/22 |
| urinary tract | 4/29 |
| uterus | 1/5 |
Essentiality in NALM6
- Essentiality Rank: 1237
- Expression level (log2 read counts): 5.12
Expression Distribution
LSM11 Expression in NALM6 Cells: 5.12
