NAPA
Gene Information
- Official Symbol: N/APA
- Official Name: NSF attachment protein alpha
- Aliases and Previous Symbols: N/A
- Entrez ID: 8775
- UniProt: P54920
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus (Probable). Together with GNA12 promotes CDH5 localization to plasma membrane (PubMed:15980433). {ECO:0000269|PubMed:15980433, ECO:0000305}.
Pfam Domains GO Terms
Pfam Domains
No Pfam Domain information is available for this gene.
GO Terms
| soluble NSF attachment protein activity |
| SNARE complex disassembly |
| synaptobrevin 2-SNAP-25-syntaxin-1a complex |
| regulation of synaptic vesicle priming |
| apical protein localization |
| synaptic vesicle priming |
| vacuolar membrane |
| synaptic transmission, glutamatergic |
| intra-Golgi vesicle-mediated transport |
| SNARE complex |
| syntaxin binding |
| positive regulation of ATPase activity |
| COPII vesicle coating |
| vesicle targeting, rough ER to cis-Golgi |
| synaptic vesicle exocytosis |
| SNARE binding |
| vesicle coating |
| exocytic process |
| COPII-coated vesicle budding |
| vesicle targeting, to, from or within Golgi |
| Golgi vesicle budding |
| regulation of synaptic vesicle exocytosis |
| regulation of ATPase activity |
| postsynapse |
| retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum |
| vesicle targeting |
| presynapse |
| vesicle budding from membrane |
| signal release from synapse |
| neurotransmitter secretion |
| regulation of neurotransmitter secretion |
| regulation of synaptic vesicle cycle |
| synaptic vesicle cycle |
| vesicle-mediated transport in synapse |
| membrane fusion |
| cellular protein complex disassembly |
| regulation of neurotransmitter transport |
| regulation of regulated secretory pathway |
| signal release |
| establishment of vesicle localization |
| neurotransmitter transport |
| vesicle localization |
| endoplasmic reticulum to Golgi vesicle-mediated transport |
| regulation of exocytosis |
| protein-containing complex disassembly |
| protein-containing complex binding |
| vesicle organization |
| glutamatergic synapse |
| regulation of neurotransmitter levels |
| establishment of organelle localization |
| Golgi vesicle transport |
| cellular component disassembly |
| chemical synaptic transmission |
| anterograde trans-synaptic signaling |
| trans-synaptic signaling |
| modulation of chemical synaptic transmission |
| regulation of trans-synaptic signaling |
| regulation of protein complex assembly |
| synaptic signaling |
| regulation of vesicle-mediated transport |
| organelle localization |
| Golgi membrane |
| regulated exocytosis |
| brain development |
| regulation of secretion by cell |
| positive regulation of hydrolase activity |
| head development |
| exocytosis |
| regulation of secretion |
| cellular protein-containing complex assembly |
| membrane organization |
| regulation of cellular localization |
| regulation of cellular component biogenesis |
| central nervous system development |
| intracellular protein transport |
| secretion by cell |
| neuron differentiation |
| export from cell |
| cell-cell signaling |
| secretion |
| regulation of hydrolase activity |
| positive regulation of catalytic activity |
| protein transport |
| intracellular transport |
| generation of neurons |
| peptide transport |
| protein-containing complex assembly |
| amide transport |
| cellular protein localization |
| cellular macromolecule localization |
| establishment of protein localization |
| neurogenesis |
| positive regulation of molecular function |
| establishment of localization in cell |
| nitrogen compound transport |
| protein-containing complex subunit organization |
| regulation of transport |
| vesicle-mediated transport |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| ISCU | 0.544 |
| CHD4 | 0.532 |
| SUPT5H | 0.508 |
| TBC1D3F | 0.506 |
| TCEB3C | 0.501 |
| COPG1 | 0.496 |
| TCEB3CL2 | 0.495 |
| COPA | 0.494 |
| SLC4A1 | 0.493 |
| EXOSC9 | 0.493 |
| TBC1D3H | 0.492 |
| CRNKL1 | 0.485 |
| CDH24 | 0.48 |
| ORC6 | 0.478 |
| CACTIN | 0.477 |
| FAM160A1 | 0.476 |
| TCEB3CL | 0.475 |
| HIST1H2BE | 0.471 |
| DISP2 | 0.471 |
| AAMP | 0.471 |
| UTP3 | 0.47 |
| PSMC5 | 0.466 |
| SH3BP1 | 0.465 |
| MBTD1 | 0.464 |
| PSMB4 | 0.462 |
| SLC6A17 | 0.462 |
| TSG101 | 0.461 |
| TFIP11 | 0.46 |
| TRAPPC11 | 0.459 |
| VASN | 0.458 |
| KIF3C | 0.458 |
| PSMD11 | 0.457 |
| CBWD3 | 0.457 |
| COPB1 | 0.454 |
| DTL | 0.454 |
| TBC1D3 | 0.452 |
| ATP6V1C1 | 0.451 |
| POLR2D | 0.45 |
| SEC13 | 0.448 |
| CBWD6 | 0.446 |
| CGB2 | 0.444 |
| AQR | 0.444 |
| RPL30 | 0.443 |
| TBC1D3G | 0.443 |
| PSMA6 | 0.442 |
| RANBP2 | 0.442 |
| PSMD3 | 0.441 |
| FAM25B | 0.441 |
| POLE | 0.441 |
| RPS2 | 0.44 |
| NOL10 | 0.44 |
| MYO1H | 0.439 |
| TICRR | 0.439 |
| PSMD7 | 0.439 |
| NARFL | 0.439 |
| CBWD5 | 0.437 |
| ITGAX | 0.437 |
| KRT78 | 0.436 |
| TRAPPC2L | 0.436 |
| TBC1D3I | 0.436 |
| WDR75 | 0.436 |
| CCNA2 | 0.436 |
| ZNF219 | 0.436 |
| TBC1D3E | 0.436 |
| TBC1D3L | 0.436 |
| VPS54 | 0.436 |
| MYT1L | 0.435 |
| TBC1D3K | 0.435 |
| HIVEP3 | 0.434 |
| ARCN1 | 0.433 |
| POLA1 | 0.433 |
| PSMB2 | 0.433 |
| RAD51 | 0.432 |
| GOLGA8O | 0.431 |
| RPS12 | 0.43 |
| CHAF1A | 0.43 |
| GOSR2 | 0.43 |
| SYT9 | 0.43 |
| COPZ1 | 0.43 |
| MYO18A | 0.429 |
| CDCA3 | 0.427 |
| KCTD17 | 0.425 |
| C14orf93 | 0.425 |
| ZFAND5 | 0.425 |
| RBM8A | 0.425 |
| RBM39 | 0.424 |
| SNRPA1 | 0.424 |
| MMS22L | 0.422 |
| CCDC64B | 0.422 |
| ORC1 | 0.422 |
| RFC1 | 0.42 |
| POLR2L | 0.419 |
| TPX2 | 0.418 |
| PSMD8 | 0.418 |
| DHX38 | 0.418 |
| SMG7 | 0.417 |
| TUBA8 | 0.417 |
| NXF1 | 0.416 |
| GAR1 | 0.416 |
| NUPL1 | 0.415 |
| PSAP | 0.415 |
| PSMC1 | 0.415 |
| CDC73 | 0.414 |
| ATP1A3 | 0.414 |
| TP53TG3B | 0.413 |
| TP53TG3 | 0.413 |
| EXOSC6 | 0.413 |
| GOLGA6B | 0.413 |
| RFPL3 | 0.412 |
| TP53TG3C | 0.412 |
| SF3A3 | 0.411 |
| NUFIP2 | 0.41 |
| RPL10A | 0.41 |
| SNIP1 | 0.41 |
| PLK4 | 0.41 |
| NUP153 | 0.41 |
| NCKAP1L | 0.41 |
| RPL35 | 0.409 |
| DDTL | 0.409 |
| HNRNPA1 | 0.408 |
| TSPY8 | 0.408 |
| AKIRIN2 | 0.408 |
| RBBP5 | 0.406 |
| WDR87 | 0.406 |
| OSBP | 0.405 |
| GID4 | 0.404 |
| ATP6V0C | 0.404 |
| MT1E | 0.403 |
| NPIPB5 | 0.403 |
| MED14 | 0.402 |
| PSMD6 | 0.402 |
| YTHDC1 | 0.402 |
| ZNF830 | 0.402 |
| ARHGEF15 | 0.402 |
| UBAP1 | 0.402 |
| EXOSC4 | 0.401 |
| NUP160 | 0.401 |
| GOLGA6A | 0.401 |
| RPS10 | 0.4 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 562/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 1/1 |
| bile duct | 18/28 |
| blood | 26/28 |
| bone | 21/26 |
| breast | 27/33 |
| central nervous system | 40/56 |
| cervix | 4/4 |
| colorectal | 14/17 |
| esophagus | 7/13 |
| fibroblast | 0/1 |
| gastric | 12/16 |
| kidney | 16/21 |
| liver | 13/20 |
| lung | 55/75 |
| lymphocyte | 14/16 |
| ovary | 25/26 |
| pancreas | 15/24 |
| peripheral nervous system | 8/16 |
| plasma cell | 15/15 |
| prostate | 0/1 |
| skin | 19/24 |
| soft tissue | 8/9 |
| thyroid | 1/2 |
| upper aerodigestive | 20/22 |
| urinary tract | 19/29 |
| uterus | 5/5 |
Essentiality in NALM6
- Essentiality Rank: 605
- Expression level (log2 read counts): 5.42
Expression Distribution
NAPA Expression in NALM6 Cells: 5.42
