POLR2F

Entrez Summary: N/A
UniProt Summary: DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II, and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2F/RPB6 is part of the clamp element and together with parts of RPB1 and RPB2 forms a pocket to which the RPB4-RPB7 subcomplex binds (By similarity). {ECO:0000250, ECO:0000269|PubMed:9852112}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Ribavirin 10 to 15μM on day4 R04 exp160	1.7
5-Azacytidine 2μM R07 exp330	1.71
A-395N 10μM R05 exp219	1.74
SGC0946 7μM R03 exp151	1.74
Dexamethasone 0.006μM R07 exp351	1.77
THZ531 0.11 to 0.125μM on day4 R07 exp410	1.82
Citral 50μM R06 exp274	1.83
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	1.87
Tunicamycin 0.04 to 0.125μM on day4 R07 exp420	1.87
Pomalidomide 20μM R07 exp391	1.9
Zebularine 20μM R07 exp423	1.93
PT-1 25μM R07 exp392	1.98
Colchicine 0.009μM R05 exp215	2
THZ531 0.11μM R07 exp409	2.04
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	2.06
Beta-Estradiol 0.55μM R07 exp425	2.13
Cidofovir 10μM R07 exp345	2.2

Global Fraction of Cell Lines Where Essential: 491/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	0/1
bile duct	23/28
blood	25/28
bone	18/25
breast	18/33
central nervous system	41/56
cervix	3/4
colorectal	12/17
esophagus	12/13
fibroblast	1/1
gastric	10/15
kidney	9/21
liver	16/20
lung	47/75
lymphocyte	10/14
ovary	17/26
pancreas	17/24
peripheral nervous system	12/16
plasma cell	12/15
prostate	1/1
skin	13/24
soft tissue	4/7
thyroid	1/2
upper aerodigestive	12/22
urinary tract	17/29
uterus	5/5

Expression Distribution

RNA polymerase II activity
RNA polymerase I activity
RNA polymerase I complex
RNA polymerase II, core complex
RNA polymerase III activity
RNA polymerase III complex
transcription elongation from RNA polymerase I promoter
termination of RNA polymerase I transcription
DNA-directed 5-3 RNA polymerase activity
7-methylguanosine mRNA capping
7-methylguanosine RNA capping
RNA capping
transcription initiation from RNA polymerase I promoter
transcription by RNA polymerase I
positive regulation of viral transcription
transcription by RNA polymerase III
positive regulation of gene expression, epigenetic
regulation of viral transcription
somatic stem cell population maintenance
snRNA transcription by RNA polymerase II
snRNA transcription
DNA-templated transcription, termination
transcription-coupled nucleotide-excision repair
transcription elongation from RNA polymerase II promoter
positive regulation of type I interferon production
fibroblast growth factor receptor signaling pathway
regulation of gene silencing by miRNA
regulation of gene silencing by RNA
regulation of posttranscriptional gene silencing
DNA-templated transcription, elongation
ncRNA transcription
positive regulation of viral process
cellular response to fibroblast growth factor stimulus
nucleotide-excision repair
response to fibroblast growth factor
regulation of type I interferon production
regulation of gene silencing
fibrillar center
stem cell population maintenance
maintenance of cell number