ATP5SL
Gene Information
- Official Symbol: DMAC2
- Official Name: distal membrane arm assembly complex 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 55101
- UniProt: Q9NW81
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Required for the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Involved in the assembly of the distal region of complex I. {ECO:0000269|PubMed:27626371}.
Pfam Domains GO Terms
Pfam Domains
No Pfam Domain information is available for this gene.
GO Terms
| mitochondrial respiratory chain complex I |
| mitochondrial respiratory chain complex I assembly |
| SCF ubiquitin ligase complex |
| NADH dehydrogenase complex assembly |
| SCF-dependent proteasomal ubiquitin-dependent protein catabolic process |
| mitochondrial respiratory chain complex assembly |
| ubiquitin-protein transferase activity |
| proteasome-mediated ubiquitin-dependent protein catabolic process |
| proteasomal protein catabolic process |
| mitochondrion organization |
| ubiquitin-dependent protein catabolic process |
| modification-dependent protein catabolic process |
| modification-dependent macromolecule catabolic process |
| proteolysis involved in cellular protein catabolic process |
| cellular protein catabolic process |
| protein catabolic process |
| protein ubiquitination |
| protein modification by small protein conjugation |
| cellular protein-containing complex assembly |
| cellular macromolecule catabolic process |
| protein modification by small protein conjugation or removal |
| macromolecule catabolic process |
| organonitrogen compound catabolic process |
| proteolysis |
| protein-containing complex assembly |
| organic substance catabolic process |
| cellular catabolic process |
| protein-containing complex subunit organization |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| NDUFB11 | 0.607 |
| NDUFAF7 | 0.567 |
| GRSF1 | 0.565 |
| NDUFC2 | 0.557 |
| MRPS21 | 0.553 |
| NDUFA3 | 0.549 |
| NDUFA1 | 0.546 |
| RTN4IP1 | 0.544 |
| NARS2 | 0.541 |
| DAP3 | 0.536 |
| HSD17B10 | 0.534 |
| TEFM | 0.533 |
| GTPBP10 | 0.53 |
| NDUFA11 | 0.528 |
| NDUFAF4 | 0.527 |
| LARS2 | 0.526 |
| MTRF1L | 0.526 |
| YARS2 | 0.525 |
| QRSL1 | 0.525 |
| ECSIT | 0.522 |
| MRPS5 | 0.519 |
| MRPL15 | 0.519 |
| NDUFA2 | 0.518 |
| MRPL47 | 0.518 |
| GFM1 | 0.517 |
| MRPS33 | 0.517 |
| MRPL21 | 0.517 |
| EARS2 | 0.514 |
| MRPS6 | 0.514 |
| NDUFB6 | 0.513 |
| ACAD9 | 0.508 |
| TMEM261 | 0.507 |
| GFM2 | 0.506 |
| PET112 | 0.506 |
| FTSJ2 | 0.506 |
| PDSS1 | 0.506 |
| RARS2 | 0.505 |
| NDUFB5 | 0.504 |
| MRPL45 | 0.503 |
| MTO1 | 0.502 |
| MRPS14 | 0.501 |
| NDUFAF6 | 0.499 |
| FASTKD2 | 0.499 |
| MARS2 | 0.499 |
| NDUFB9 | 0.498 |
| RNASEH1 | 0.498 |
| C12orf65 | 0.495 |
| DARS2 | 0.495 |
| MRPS16 | 0.495 |
| GATC | 0.491 |
| C10orf2 | 0.489 |
| RPUSD3 | 0.486 |
| NDUFS2 | 0.485 |
| NDUFAF3 | 0.484 |
| CARS2 | 0.483 |
| MRPS34 | 0.482 |
| MRP63 | 0.479 |
| TARS2 | 0.479 |
| C17orf89 | 0.478 |
| WBSCR16 | 0.475 |
| SELRC1 | 0.473 |
| NDUFS7 | 0.471 |
| NDUFB7 | 0.47 |
| NDUFB3 | 0.469 |
| RPUSD4 | 0.466 |
| TUFM | 0.464 |
| MRPL53 | 0.463 |
| NDUFS5 | 0.463 |
| AIFM1 | 0.461 |
| MRPL23 | 0.46 |
| MTG2 | 0.459 |
| RBFA | 0.458 |
| NDUFA10 | 0.456 |
| NDUFA8 | 0.455 |
| PNPT1 | 0.454 |
| PARS2 | 0.454 |
| TIMMDC1 | 0.452 |
| NDUFAF1 | 0.452 |
| SSBP1 | 0.451 |
| FOXRED1 | 0.451 |
| MIPEP | 0.448 |
| POLG | 0.445 |
| NDUFV1 | 0.444 |
| RNMTL1 | 0.444 |
| MTERFD1 | 0.443 |
| NDUFS3 | 0.442 |
| MRPS22 | 0.442 |
| HMGXB3 | 0.442 |
| MRPL42 | 0.44 |
| MCAT | 0.44 |
| MTG1 | 0.439 |
| NUBPL | 0.438 |
| MRPL12 | 0.438 |
| POLRMT | 0.437 |
| MRPS26 | 0.436 |
| NFU1 | 0.434 |
| FASTKD5 | 0.434 |
| COX16 | 0.433 |
| METTL17 | 0.432 |
| TIMM21 | 0.432 |
| CHCHD1 | 0.431 |
| MRPS25 | 0.43 |
| MRPL22 | 0.429 |
| NDUFAF5 | 0.428 |
| SLC25A26 | 0.425 |
| SARS2 | 0.425 |
| MRPS11 | 0.424 |
| MTIF2 | 0.424 |
| DDX28 | 0.423 |
| TFB1M | 0.423 |
| POLG2 | 0.423 |
| KIAA0391 | 0.422 |
| MRPL3 | 0.422 |
| AASDHPPT | 0.419 |
| AARS2 | 0.419 |
| WARS2 | 0.419 |
| IBA57 | 0.417 |
| NDUFB2 | 0.417 |
| HARS2 | 0.416 |
| COX17 | 0.415 |
| TOMM20 | 0.415 |
| COQ7 | 0.413 |
| BCS1L | 0.412 |
| MRPS9 | 0.412 |
| PGM3 | 0.41 |
| TRMT10C | 0.409 |
| VARS2 | 0.409 |
| MRPL17 | 0.408 |
| TMEM242 | 0.406 |
| MRPL4 | 0.404 |
| COQ2 | 0.402 |
| SCO2 | 0.402 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 2398
- Expression level (log2 read counts): 5.12
Expression Distribution
ATP5SL Expression in NALM6 Cells: 5.12
