COQ3
Gene Information
- Official Symbol: COQ3
- Official Name: coenzyme Q3, methyltransferase
- Aliases and Previous Symbols: N/A
- Entrez ID: 51805
- UniProt: Q9NZJ6
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway. {ECO:0000255|HAMAP- Rule:MF_03190}.
Pfam Domains GO Terms
Pfam Domains
| Methyltransf 11 |
| CMAS |
| Methyltransf 18 |
| Ubie methyltran |
| Methyltransf 12 |
GO Terms
| 3-demethylubiquinone-9 3-O-methyltransferase activity |
| 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity |
| hexaprenyldihydroxybenzoate methyltransferase activity |
| decaprenyldihydroxybenzoate methyltransferase activity |
| 3-demethylubiquinone-10 3-O-methyltransferase activity |
| 3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity |
| regulation of ubiquinone biosynthetic process |
| O-methyltransferase activity |
| regulation of coenzyme metabolic process |
| extrinsic component of mitochondrial inner membrane |
| quinone biosynthetic process |
| regulation of ketone biosynthetic process |
| ubiquinone biosynthetic process |
| ubiquinone metabolic process |
| glycerol metabolic process |
| alditol metabolic process |
| ketone biosynthetic process |
| quinone metabolic process |
| regulation of cofactor metabolic process |
| oxidoreduction coenzyme metabolic process |
| cellular ketone metabolic process |
| polyol metabolic process |
| coenzyme biosynthetic process |
| cellular carbohydrate metabolic process |
| regulation of cellular ketone metabolic process |
| cofactor biosynthetic process |
| coenzyme metabolic process |
| methylation |
| alcohol metabolic process |
| mitochondrial matrix |
| regulation of small molecule metabolic process |
| cofactor metabolic process |
| organic hydroxy compound metabolic process |
| carbohydrate metabolic process |
| small molecule biosynthetic process |
| mitochondrion |
| small molecule metabolic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| COQ6 | 0.579 |
| MRPL21 | 0.553 |
| COQ2 | 0.544 |
| TIMM8B | 0.542 |
| GTPBP10 | 0.53 |
| MRPS18A | 0.527 |
| SUPV3L1 | 0.515 |
| COQ7 | 0.511 |
| KIAA0391 | 0.506 |
| MRPL23 | 0.505 |
| YARS2 | 0.501 |
| SLC25A26 | 0.498 |
| MTRF1L | 0.495 |
| MRPS34 | 0.493 |
| OPA1 | 0.488 |
| RNASEH1 | 0.487 |
| DNLZ | 0.485 |
| NDUFAF7 | 0.483 |
| VARS2 | 0.481 |
| TARS2 | 0.477 |
| TIMM17A | 0.476 |
| DAP3 | 0.475 |
| HSD17B10 | 0.473 |
| GFM1 | 0.472 |
| C12orf65 | 0.472 |
| TAZ | 0.47 |
| MRP63 | 0.47 |
| NDUFB11 | 0.469 |
| PDSS1 | 0.469 |
| RPUSD4 | 0.468 |
| TRIAP1 | 0.467 |
| CRLS1 | 0.467 |
| SELRC1 | 0.466 |
| MRPS5 | 0.465 |
| C17orf89 | 0.465 |
| MRPS10 | 0.464 |
| TEFM | 0.463 |
| UQCC2 | 0.46 |
| PITRM1 | 0.459 |
| MRPS24 | 0.457 |
| MTG1 | 0.456 |
| MTPAP | 0.454 |
| NDUFA3 | 0.452 |
| DHX30 | 0.449 |
| PARS2 | 0.448 |
| MTG2 | 0.448 |
| NARS2 | 0.446 |
| MRPL44 | 0.444 |
| ROMO1 | 0.443 |
| WBSCR16 | 0.443 |
| EARS2 | 0.443 |
| IBA57 | 0.443 |
| MRPL53 | 0.442 |
| NDUFAF3 | 0.442 |
| TMEM242 | 0.441 |
| QRSL1 | 0.439 |
| AARS2 | 0.439 |
| PTPMT1 | 0.438 |
| GTPBP6 | 0.438 |
| FASTKD5 | 0.437 |
| PNPT1 | 0.436 |
| PGP | 0.436 |
| MRPS16 | 0.433 |
| MRPS6 | 0.433 |
| MRPS12 | 0.432 |
| MRPS21 | 0.431 |
| ALAS1 | 0.431 |
| TRUB2 | 0.431 |
| BCS1L | 0.43 |
| MTIF3 | 0.43 |
| GATC | 0.428 |
| GLRX5 | 0.428 |
| SCO2 | 0.428 |
| COQ5 | 0.426 |
| MRPS11 | 0.424 |
| MRPL55 | 0.424 |
| LARS2 | 0.423 |
| GFM2 | 0.422 |
| TOMM20 | 0.422 |
| MRPL12 | 0.421 |
| RPE | 0.42 |
| RBFA | 0.414 |
| WARS2 | 0.413 |
| FECH | 0.412 |
| AASDHPPT | 0.411 |
| COA6 | 0.406 |
| TOMM40 | 0.406 |
| FTSJ2 | 0.405 |
| MCAT | 0.405 |
| UQCRC2 | 0.404 |
| TUFM | 0.404 |
| C10orf2 | 0.402 |
| PGLS | 0.402 |
| MRPS9 | 0.402 |
| PGM3 | 0.402 |
| ATP5A1 | 0.4 |
| PTRHD1 | 0.4 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/25 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/15 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/14 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/7 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 2065
- Expression level (log2 read counts): 3.87
Expression Distribution
COQ3 Expression in NALM6 Cells: 3.87
