DOLK
Gene Information
- Official Symbol: DOLK
- Official Name: dolichol kinase
- Aliases and Previous Symbols: N/A
- Entrez ID: 22845
- UniProt: Q9UPQ8
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene catalyzes the CTP-mediated phosphorylation of dolichol, and is involved in the synthesis of Dol-P-Man, which is an essential glycosyl carrier lipid for C- and O-mannosylation, N- and O-linked glycosylation of proteins, and for the biosynthesis of glycosyl phosphatidylinositol anchors in endoplasmic reticulum. Mutations in this gene are associated with dolichol kinase deficiency.[provided by RefSeq, Apr 2010].
- UniProt Summary: Involved in the synthesis of the sugar donor Dol-P-Man which is required in the synthesis of N-linked and O-linked oligosaccharides and for that of GPI anchors. {ECO:0000250}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 306
- Expression level (log2 read counts): 3.87
DOLK Expression in NALM6 Cells: 3.87
