DR1
Gene Information
- Official Symbol: DR1
- Official Name: down-regulator of transcription 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 1810
- UniProt: Q01658
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. {ECO:0000269|PubMed:19103755, ECO:0000269|PubMed:8670811}.
Pfam Domains GO Terms
Pfam Domains
| CBFD NFYB HMF |
GO Terms
| negative cofactor 2 complex |
| core promoter binding |
| regulation of RNA polymerase II transcriptional preinitiation complex assembly |
| Ada2/Gcn5/Ada3 transcription activator complex |
| TBP-class protein binding |
| regulation of transcription initiation from RNA polymerase II promoter |
| regulation of DNA-templated transcription, initiation |
| histone H3 acetylation |
| histone acetylation |
| internal peptidyl-lysine acetylation |
| peptidyl-lysine acetylation |
| internal protein amino acid acetylation |
| protein acetylation |
| chromatin remodeling |
| protein acylation |
| transcription corepressor activity |
| transcription coactivator activity |
| peptidyl-lysine modification |
| transcription factor binding |
| histone modification |
| covalent chromatin modification |
| regulation of protein complex assembly |
| protein heterodimerization activity |
| chromatin organization |
| negative regulation of transcription by RNA polymerase II |
| peptidyl-amino acid modification |
| regulation of cellular component biogenesis |
| chromosome organization |
| negative regulation of transcription, DNA-templated |
| positive regulation of transcription by RNA polymerase II |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of RNA metabolic process |
| negative regulation of cellular macromolecule biosynthetic process |
| negative regulation of nucleobase-containing compound metabolic process |
| DNA binding |
| negative regulation of macromolecule biosynthetic process |
| negative regulation of cellular biosynthetic process |
| positive regulation of transcription, DNA-templated |
| negative regulation of biosynthetic process |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| THG1L | 0.672 |
| RPTOR | 0.565 |
| TSEN54 | 0.554 |
| ORAOV1 | 0.551 |
| ATXN10 | 0.548 |
| DOHH | 0.544 |
| ALG1 | 0.543 |
| RPP21 | 0.531 |
| PPP6C | 0.531 |
| UAP1 | 0.522 |
| ADSL | 0.522 |
| GTF3C3 | 0.518 |
| SRP14 | 0.511 |
| MED16 | 0.509 |
| GMPPB | 0.509 |
| ATIC | 0.503 |
| RTCB | 0.5 |
| WDR24 | 0.497 |
| GTF3C6 | 0.494 |
| BTAF1 | 0.493 |
| NAE1 | 0.493 |
| DPAGT1 | 0.493 |
| VHL | 0.491 |
| PMM2 | 0.49 |
| RNMT | 0.486 |
| GFPT1 | 0.486 |
| TEN1 | 0.485 |
| C15orf41 | 0.484 |
| GEMIN7 | 0.483 |
| TRMT61A | 0.476 |
| FH | 0.473 |
| GNB1L | 0.473 |
| GEMIN8 | 0.471 |
| BAP1 | 0.47 |
| PPCS | 0.469 |
| ALG13 | 0.467 |
| GEMIN6 | 0.466 |
| VEZT | 0.464 |
| EXOC4 | 0.464 |
| PELO | 0.463 |
| TRNT1 | 0.462 |
| URM1 | 0.462 |
| TTI2 | 0.461 |
| SSB | 0.459 |
| ELP3 | 0.458 |
| BAK1 | 0.458 |
| UHRF1 | 0.457 |
| RPIA | 0.457 |
| TRIAP1 | 0.457 |
| TBCB | 0.455 |
| UBE2M | 0.454 |
| UBA3 | 0.454 |
| TTC4 | 0.452 |
| GTF3C4 | 0.45 |
| SLC25A19 | 0.448 |
| TPK1 | 0.446 |
| ENY2 | 0.445 |
| TRIM28 | 0.444 |
| WDR59 | 0.444 |
| FBXO11 | 0.441 |
| DDX1 | 0.44 |
| LSM10 | 0.44 |
| OIP5 | 0.438 |
| SLC25A26 | 0.438 |
| TSEN34 | 0.438 |
| PPP2R3C | 0.437 |
| SNAPC5 | 0.437 |
| HAUS8 | 0.436 |
| N6AMT1 | 0.436 |
| RABGGTB | 0.435 |
| RFK | 0.432 |
| MOCS3 | 0.432 |
| KCTD5 | 0.432 |
| MSTO1 | 0.43 |
| KDSR | 0.427 |
| LAMTOR5 | 0.427 |
| MED4 | 0.425 |
| TXNRD1 | 0.425 |
| UBE2G2 | 0.425 |
| ATP5J | 0.424 |
| DHPS | 0.424 |
| PTAR1 | 0.423 |
| TTI1 | 0.423 |
| DOLK | 0.422 |
| ATP5B | 0.422 |
| NSD1 | 0.421 |
| PLAA | 0.42 |
| WDR92 | 0.42 |
| HCCS | 0.419 |
| CASP9 | 0.419 |
| UXT | 0.419 |
| RFT1 | 0.418 |
| ZZZ3 | 0.417 |
| ALG2 | 0.416 |
| TELO2 | 0.416 |
| LSM11 | 0.416 |
| HSPD1 | 0.415 |
| EEF1E1 | 0.415 |
| DDX55 | 0.415 |
| WDR1 | 0.415 |
| DRAP1 | 0.412 |
| ROMO1 | 0.412 |
| CTC1 | 0.411 |
| MED23 | 0.409 |
| EIF4E | 0.408 |
| DDOST | 0.408 |
| MTOR | 0.408 |
| ID3 | 0.408 |
| MLLT1 | 0.406 |
| TRIP12 | 0.404 |
| AASDHPPT | 0.404 |
| POLR3H | 0.403 |
| GTF3A | 0.402 |
| ELP2 | 0.402 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 159/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 8/28 |
| blood | 7/28 |
| bone | 4/25 |
| breast | 4/33 |
| central nervous system | 13/56 |
| cervix | 0/4 |
| colorectal | 4/17 |
| esophagus | 2/13 |
| fibroblast | 1/1 |
| gastric | 3/15 |
| kidney | 4/21 |
| liver | 3/20 |
| lung | 16/75 |
| lymphocyte | 3/14 |
| ovary | 6/26 |
| pancreas | 8/24 |
| peripheral nervous system | 1/16 |
| plasma cell | 10/15 |
| prostate | 0/1 |
| skin | 9/24 |
| soft tissue | 0/7 |
| thyroid | 1/2 |
| upper aerodigestive | 4/22 |
| urinary tract | 13/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 2385
- Expression level (log2 read counts): 6.96
Expression Distribution
DR1 Expression in NALM6 Cells: 6.96
