SLC5A3
Gene Information
- Official Symbol: SLC5A3
- Official Name: solute carrier family 5 member 3
- Aliases and Previous Symbols: N/A
- Entrez ID: 6526
- UniProt: P53794
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Prevents intracellular accumulation of high concentrations of myo-inositol (an osmolyte) that result in impairment of cellular function.
Pfam Domains GO Terms
Pfam Domains
| SSF |
GO Terms
| myo-inositol:sodium symporter activity |
| myo-inositol transport |
| glucose:sodium symporter activity |
| polyol transport |
| inositol metabolic process |
| regulation of respiratory gaseous exchange |
| glucose transmembrane transport |
| hexose transmembrane transport |
| monosaccharide transmembrane transport |
| carbohydrate transmembrane transport |
| peripheral nervous system development |
| carbohydrate transport |
| polyol metabolic process |
| organic hydroxy compound transport |
| sodium ion transport |
| cellular carbohydrate metabolic process |
| alcohol metabolic process |
| monovalent inorganic cation transport |
| organic hydroxy compound metabolic process |
| carbohydrate metabolic process |
| metal ion transport |
| cation transport |
| transmembrane transport |
| ion transport |
| integral component of plasma membrane |
| small molecule metabolic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 5/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 3/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 1847
- Expression level (log2 read counts): 7.58
Expression Distribution
SLC5A3 Expression in NALM6 Cells: 7.58
