BYSL
Gene Information
- Official Symbol: BYSL
- Official Name: bystin like
- Aliases and Previous Symbols: N/A
- Entrez ID: 705
- UniProt: Q13895
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos. {ECO:0000269|PubMed:17360433, ECO:0000269|PubMed:17381424}.
Pfam Domains GO Terms
Pfam Domains
| Bystin |
GO Terms
| regulation of protein localization to nucleolus |
| preribosome, small subunit precursor |
| trophectodermal cell differentiation |
| snoRNA binding |
| maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) |
| blastocyst formation |
| maturation of SSU-rRNA |
| ribosomal small subunit biogenesis |
| apical part of cell |
| blastocyst development |
| regulation of protein localization to nucleus |
| female pregnancy |
| multi-multicellular organism process |
| rRNA processing |
| rRNA metabolic process |
| ribosome biogenesis |
| in utero embryonic development |
| ncRNA processing |
| ribonucleoprotein complex biogenesis |
| ncRNA metabolic process |
| regulation of cellular protein localization |
| cell population proliferation |
| chordate embryonic development |
| embryo development ending in birth or egg hatching |
| intracellular membrane-bounded organelle |
| nucleolus |
| RNA processing |
| anatomical structure formation involved in morphogenesis |
| regulation of cellular localization |
| cell adhesion |
| biological adhesion |
| embryo development |
| multi-organism reproductive process |
| regulation of protein localization |
| RNA binding |
| reproductive process |
| reproduction |
| RNA metabolic process |
| membrane |
| gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| CBWD6 | 0.548 |
| CBWD5 | 0.546 |
| TCEB3CL2 | 0.538 |
| CBWD3 | 0.536 |
| LRR1 | 0.517 |
| PSMB4 | 0.516 |
| TCEB3C | 0.514 |
| GOLGA6L4 | 0.514 |
| KCTD17 | 0.506 |
| RPL35 | 0.504 |
| TCEB3CL | 0.503 |
| GOLGA6L3 | 0.496 |
| SF3A1 | 0.49 |
| GOLGA8J | 0.489 |
| PSMB2 | 0.488 |
| RBBP5 | 0.486 |
| RPS3A | 0.483 |
| IGFN1 | 0.482 |
| CCNA2 | 0.482 |
| C14orf93 | 0.48 |
| PWP2 | 0.48 |
| PSMB1 | 0.479 |
| RPS2 | 0.476 |
| RPS5 | 0.475 |
| TYMS | 0.474 |
| TSPY8 | 0.473 |
| NPIPB5 | 0.472 |
| RPS11 | 0.471 |
| PSMA7 | 0.471 |
| PCF11 | 0.47 |
| NOL10 | 0.469 |
| RPS12 | 0.468 |
| PSMD2 | 0.467 |
| TBC1D3I | 0.466 |
| TBC1D3L | 0.466 |
| TBC1D3F | 0.466 |
| TBC1D3E | 0.466 |
| TBC1D3G | 0.466 |
| TBC1D3K | 0.466 |
| COPG1 | 0.466 |
| TBC1D3 | 0.465 |
| RRP7A | 0.465 |
| TBC1D3H | 0.465 |
| CHD4 | 0.464 |
| HGC6.3 | 0.461 |
| PSMD3 | 0.459 |
| RPS19 | 0.459 |
| COPB2 | 0.456 |
| ORC6 | 0.456 |
| EXOSC4 | 0.455 |
| HIST2H3A | 0.455 |
| HIST2H3C | 0.455 |
| SLC38A7 | 0.454 |
| ORC1 | 0.454 |
| POLA1 | 0.453 |
| ANKLE2 | 0.451 |
| SF3A3 | 0.451 |
| DDTL | 0.451 |
| MT1E | 0.45 |
| VASN | 0.447 |
| TFIP11 | 0.447 |
| RPS7 | 0.446 |
| BRIX1 | 0.445 |
| EXOSC9 | 0.443 |
| POLE | 0.442 |
| SSH2 | 0.441 |
| SUPT5H | 0.44 |
| GOLGA6L1 | 0.44 |
| RRP15 | 0.439 |
| GOLGA8O | 0.439 |
| KRT78 | 0.438 |
| WDR75 | 0.438 |
| CDC6 | 0.438 |
| ATP6V1C1 | 0.438 |
| NUPL1 | 0.437 |
| NUP133 | 0.436 |
| AQR | 0.435 |
| CDCA5 | 0.434 |
| TICRR | 0.434 |
| NGDN | 0.43 |
| CCDC116 | 0.43 |
| PLK4 | 0.43 |
| IK | 0.429 |
| MYO1H | 0.428 |
| PSMD1 | 0.427 |
| GOLGA6L6 | 0.427 |
| TWISTNB | 0.427 |
| DDX56 | 0.426 |
| RRP9 | 0.425 |
| TBC1D3C | 0.425 |
| RRP12 | 0.424 |
| UTP20 | 0.423 |
| PHF2 | 0.421 |
| CEP192 | 0.419 |
| NBPF10 | 0.419 |
| FAM231C | 0.418 |
| FAM231A | 0.418 |
| PSMD11 | 0.418 |
| PSMD14 | 0.418 |
| MDM2 | 0.417 |
| TERF1 | 0.417 |
| SART1 | 0.417 |
| WDR46 | 0.416 |
| POLR2F | 0.416 |
| RPL6 | 0.416 |
| CASC3 | 0.416 |
| ARCN1 | 0.416 |
| CACTIN | 0.415 |
| ATP6AP1 | 0.414 |
| PSMA6 | 0.414 |
| ELMOD3 | 0.413 |
| EBNA1BP2 | 0.413 |
| RNF113A | 0.412 |
| LIPE | 0.412 |
| MYB | 0.411 |
| PDE4DIP | 0.411 |
| RPS9 | 0.411 |
| RPL34 | 0.41 |
| INCENP | 0.41 |
| AKIRIN2 | 0.409 |
| POLR2J3 | 0.408 |
| DISP2 | 0.407 |
| DDX21 | 0.407 |
| RILPL1 | 0.407 |
| GOLGA8K | 0.406 |
| SULT1A4 | 0.406 |
| SULT1A3 | 0.406 |
| TSR1 | 0.405 |
| SLC6A17 | 0.405 |
| POLA2 | 0.405 |
| ZNF830 | 0.404 |
| XAB2 | 0.404 |
| C1QTNF9B | 0.403 |
| PLEKHA4 | 0.402 |
| ADRM1 | 0.402 |
| POLR2H | 0.402 |
| RPL9 | 0.402 |
| CGB2 | 0.4 |
| DNTTIP2 | 0.4 |
| RAD21 | 0.4 |
| ATP6V0C | 0.4 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 705/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 1/1 |
| bile duct | 25/28 |
| blood | 28/28 |
| bone | 25/26 |
| breast | 29/33 |
| central nervous system | 53/56 |
| cervix | 4/4 |
| colorectal | 15/17 |
| esophagus | 13/13 |
| fibroblast | 0/1 |
| gastric | 16/16 |
| kidney | 18/21 |
| liver | 19/20 |
| lung | 73/75 |
| lymphocyte | 14/16 |
| ovary | 24/26 |
| pancreas | 23/24 |
| peripheral nervous system | 16/16 |
| plasma cell | 15/15 |
| prostate | 1/1 |
| skin | 24/24 |
| soft tissue | 9/9 |
| thyroid | 2/2 |
| upper aerodigestive | 21/22 |
| urinary tract | 26/29 |
| uterus | 5/5 |
Essentiality in NALM6
- Essentiality Rank: 950
- Expression level (log2 read counts): 5.95
Expression Distribution
BYSL Expression in NALM6 Cells: 5.95
