EIF4A1

Gene Information

Official Symbol: EIF4A1
Official Name: eukaryotic translation initiation factor 4A1
Aliases and Previous Symbols: N/A
Entrez ID: 1973
UniProt: P60842
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. {ECO:0000269|PubMed:19153607, ECO:0000269|PubMed:19204291}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
ABT-702 5μM plus CoCl2 18μM R07 exp320	-2.57
Ribavirin 10 to 15μM on day4 R04 exp160	-2.38
CoCl2 18μM R07 exp346	-2.34
Apcin 50 to 100μM on day4 R04 exp176	-2.05
Apcin 25μM plus proTAME 2μM R04 exp177	-2.02
Docosahexaenoic-acid 50μM R07 exp356	-1.93
Metformin 100 to 150μM on day4 R04 exp170	-1.82
A-395N 10μM R05 exp219	-1.78
Epothilone-B 0.0015μM R05 exp231	1.7
MS023 2μM R03 exp134	1.7
Q15 1 to 2μM on day4 R04 exp164	1.71
GSK461364A 0.005μM R03 exp125	1.72
MS023 7μM R03 exp135	1.72
AICAR 240μM R03 exp116	1.73
BI-6727 0.0125μM R03 exp97	1.73
NN-Diethyl-meta-toluamide 500μM R08 exp438	1.73
Bisphenol A 100μM R06 exp269	1.74
AICAR 240μM R05 exp211	1.76
Colchicine 0.009μM R05 exp215	1.8
5-Fluorouracil 20μM R00 exp2	1.83
LY2090314 0.003μM R08 exp500 no dilution day6	1.84
Dimethyl-Sulfoxide 1pc R03 exp120	1.85
Wortmannin 5μM R00 exp38	1.89
Docetaxel 0.002μM R01 exp45	1.9
Tanespimycin 14μM R08 exp527	1.99
Genistein 15μM R07 exp360	2.01
Thapsigargin 0.005μM R07 exp407	2.02
Betulinic acid 10 to 15μM on day4 R05 exp222	2.1
Aphidicolin 0.4μM R08 exp440	2.11
Benzoate 20000μM R08 exp456	2.13
INK128 0.2μM R02 exp70	2.14
Bortezomib 0.05μM R00 exp7	2.18
iCRT14 30μM R08 exp492	2.18
Cyclosporin-A 3μM R07 exp348	2.22
I-BRD9 4μM R07 exp365	2.22
Torin1 0.08μM R02 exp82	2.22
THZ1 0.06μM R08 exp531	2.23
Arsenic trioxide 60μM R08 exp449	2.26
Cannabidiol 20μM R08 exp466	2.26
WYE-354 6μM R02 exp90	2.27
Talazoparib 0.006μM R06 exp299	2.3
Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307	2.31
Vitamin-D3 40μM R08 exp536	2.31
∆-9-Tetrahydrocannabinol 30μM R08 exp445	2.35
THZ531 0.11 to 0.175μM on day4 R07 exp413	2.38
Pterostilbene 16μM R02 exp78	2.4
Dorsomorphin 5μM R07 exp357	2.42
BI-D1870 3.15μM R02 exp66	2.53
Citral 50μM R06 exp274	2.59
Dynasore 10μM R04 exp180	2.59
PU-H71 1μM R08 exp515	2.59
Quercetin 20μM R08 exp517	2.69
Dynasore 7μM R08 exp436	2.71
RO-3307 4.7μM R02 exp80	2.77
Sulforaphane 9μM R08 exp526 no dilution day6	2.78
Ethanol 0.01 R05 exp234	2.8
2-Deoxy-D-glucose 800μM R05 exp214	2.84
Thimerosal 0.85μM R08 exp529	2.91
FK-506 30μM R07 exp359	2.99
BS-181 20μM R08 exp461	3
Cryptotanshinone 12μM R05 exp227	3.04
Hydroxyurea 100μM R07 exp329	3.04
Amiloride 100μM R08 exp447	3.06
5-Azacytidine 2μM R07 exp330	3.08
Sulforaphane 9μM R08 exp525	3.13
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	3.14
Calcium Ionophore 0.4μM R07 exp342	3.19
Dinaciclib 0.007μM R07 exp355	3.2
VER-155008 3.9μM R06 exp301	3.21
6-Thio-2-deoxyguanosine 2μM R06 exp259	3.37
All-trans-Retinoic-Acid 40μM R07 exp334	3.47
Vincristine 0.0005μM R04 exp190	3.51
Cytochalasin-B 5μM R07 exp349	3.52
CB-5083 0.4μM R08 exp468	3.57
Olaparib 4μM R08 exp512	3.57
UM0125461 0.74μM R02 exp84	3.58
Etoposide 0.3μM R05 exp199	3.63
TRAIL 50ng/ml R00 exp36	3.83
Tubacin 1.6μM R07 exp416	3.86
Erlotinib 10μM R05 exp216	3.93
Etoposide 0.1μM R05 exp198	4.03
Actinomycin-D 0.001μM R00 exp3	4.08
MK2206 4μM R08 exp504	4.1
Doxorubicin 0.02μM R08 exp478	4.33
ML-792 0.2μM R08 exp505	4.41
LB-100 2μM R05 exp210	4.42
Lead acetate 2000μM R08 exp497	4.44
Lead acetate 2000μM R08 exp498 no dilution day6	4.5
Pyridostatin 4μM R05 exp240	4.5
TRAIL 5ng/ml R00 exp35	4.5
Latrunculin-B 10μM R07 exp374	4.54
Fluvastatin 2.2μM R06 exp282	4.6
Tozasertib 0.1μM R07 exp414	4.63
MK-1775 0.32μM R02 exp75	4.65
THZ531 0.225μM R08 exp444	4.95
LB-100 4.1μM R02 exp72	5.31
MLN-4924 0.2μM R00 exp21	5.45
Radicicol 0.16μM R05 exp242	6.11
Bortezomib 0.005μM R00 exp6	7.24
GSK626616 14μM R08 exp485	7.54
Hippuristanol 0.12μM R08 exp488	7.61
Hippuristanol 0.12μM R08 exp489 no dilution day6	7.64

Global Fraction of Cell Lines Where Essential: 679/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	1/1
bile duct	26/28
blood	27/28
bone	24/26
breast	30/33
central nervous system	51/56
cervix	4/4
colorectal	16/17
esophagus	11/13
fibroblast	0/1
gastric	16/16
kidney	20/21
liver	20/20
lung	68/75
lymphocyte	16/16
ovary	20/26
pancreas	24/24
peripheral nervous system	15/16
plasma cell	14/15
prostate	0/1
skin	23/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	17/22
urinary tract	27/29
uterus	5/5

Essentiality in NALM6

Essentiality Rank: 2493
Expression level (log2 read counts): 9.3

Expression Distribution

Gene	Correlation
RPS25	0.46
ZFC3H1	0.456
CCNL1	0.44
EIF3G	0.433
C9orf78	0.413
IKZF2	0.409
PMAIP1	0.408

DEAD
Helicase C

RNA cap binding
eukaryotic translation initiation factor 4F complex
translation factor activity, RNA binding
cytoplasmic translational initiation
helicase activity
translation initiation factor activity
RNA helicase activity
double-stranded RNA binding
cytoplasmic translation
translational initiation
mRNA binding
translation
peptide biosynthetic process
amide biosynthetic process
peptide metabolic process
viral process
symbiotic process
cellular amide metabolic process
interspecies interaction between organisms
RNA binding
organonitrogen compound biosynthetic process
ATP binding
cellular nitrogen compound biosynthetic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
membrane
gene expression