OGFR

Gene Information

Official Symbol: OGFR
Official Name: opioid growth factor receptor
Aliases and Previous Symbols: N/A
Entrez ID: 11054
UniProt: Q9NZT2
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is a receptor for opioid growth factor (OGF), also known as [Met(5)]-enkephalin. OGF is a negative regulator of cell proliferation and tissue organization in a variety of processes. The encoded unbound receptor for OGF has been localized to the outer nuclear envelope, where it binds OGF and is translocated into the nucleus. The coding sequence of this gene contains a polymorphic region of 60 nt tandem imperfect repeat units. Several transcripts containing between zero and eight repeat units have been reported. [provided by RefSeq, Jul 2008].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Etoposide 10μM R00 exp20	-2.08
Actinomycin-D 0.01μM R00 exp4	-1.94
Q15 1 to 2μM on day4 R04 exp164	1.73
Geldanamycin 0.01μM R05 exp235	1.81
Vinorelbine 0.001μM R05 exp249	2.11

Gene	Correlation
VASN	0.551
TBC1D3C	0.541
TBC1D3G	0.523
POLR2J3	0.515
VPS54	0.513
DNTTIP2	0.511
TBC1D3H	0.509
TBC1D3F	0.504
PSMA6	0.504
SMG1	0.503
HGC6.3	0.5
TERF1	0.495
KIF3C	0.487
TCEB3CL2	0.485
RPS12	0.484
ORC1	0.481
TBC1D3L	0.481
TBC1D3	0.481
PCF11	0.48
TBC1D3E	0.48
TBC1D3K	0.48
SUPT6H	0.48
CBWD3	0.48
TBC1D3I	0.479
UPF1	0.476
POLR2D	0.476
DISP2	0.475
CHD4	0.475
TWISTNB	0.474
NOL10	0.468
TTC1	0.467
C1QTNF9B	0.465
CHCHD3	0.465
TFIP11	0.462
FAM86B2	0.461
CCNA2	0.46
CBWD5	0.457
AQR	0.457
RPSA	0.456
ZFAND5	0.455
MED29	0.454
ZNF106	0.454
PSMD7	0.453
NPIPB5	0.453
PAN2	0.452
EXOSC5	0.452
ANKLE1	0.451
PSMD3	0.451
CDC45	0.451
TCEB3C	0.45
SUPT5H	0.45
SMG5	0.448
RBBP5	0.446
MED17	0.446
STIL	0.444
RPS14	0.444
TCEB3CL	0.444
CBWD6	0.444
AKIRIN2	0.442
PSMD6	0.442
AATF	0.442
UTP20	0.441
GOLGA6B	0.44
PSMB4	0.44
MT1E	0.437
PSMD1	0.437
SNRPA1	0.436
CMYA5	0.436
NUP54	0.436
KCTD17	0.436
POLR1A	0.435
MYB	0.435
PSMC6	0.435
C14orf93	0.435
RNF121	0.435
EXOSC9	0.434
DDTL	0.434
RPS19BP1	0.434
NUP107	0.433
PWP2	0.433
TRAPPC8	0.432
NOL12	0.431
CCDC64B	0.431
TP53TG3D	0.431
CDCA3	0.431
GOLGA6A	0.429
RAD51	0.429
RPS2	0.429
ARCN1	0.429
POLA1	0.429
PLK4	0.426
MBTD1	0.426
PSMD13	0.426
ORC6	0.426
PSMD11	0.426
KPNB1	0.426
HSPA5	0.425
PSMC2	0.425
PPP1R15B	0.424
SYT9	0.424
SLC6A17	0.424
RIOK2	0.424
RAD21	0.424
SMG7	0.422
AAAS	0.422
RPS28	0.421
IGFN1	0.421
TIMELESS	0.42
DYNC1I2	0.42
HIST2H2BF	0.419
PSMB1	0.419
SLC4A1	0.419
H3F3A	0.419
TP53TG3B	0.419
TP53TG3	0.418
TP53TG3C	0.418
WDR43	0.418
CEP192	0.417
ATP6V0C	0.417
TYMS	0.416
FUT11	0.416
NBPF10	0.416
MED14	0.416
BCL2L1	0.414
RPL7A	0.414
YTHDC1	0.414
USPL1	0.413
DTL	0.412
NUP205	0.411
RFXANK	0.41
ACSF2	0.41
COPB1	0.409
ATP6V1C1	0.409
C2orf27B	0.408
POLA2	0.407
HAP1	0.407
COPE	0.407
TERF2	0.407
ACTL7A	0.406
SEC13	0.406
RANBP2	0.405
GID4	0.405
XAB2	0.404
PBXIP1	0.404
TOP1MT	0.403
TICRR	0.403
NOP16	0.403
RPL35	0.403
S1PR4	0.402
GOLGA8O	0.402
HIST1H2BE	0.402
SCAF1	0.401
TSPY1	0.401
FBXL19	0.4

Global Fraction of Cell Lines Where Essential: 2/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 1942
Expression level (log2 read counts): 5.96

Expression Distribution

OGFr III
OGFr N

opioid receptor activity
opioid receptor signaling pathway
regulation of cell growth
cellular component
regulation of growth
G protein-coupled receptor signaling pathway
membrane