SEC62
Gene Information
- Official Symbol: SEC62
- Official Name: SEC62 homolog, preprotein translocation factor
- Aliases and Previous Symbols: N/A
- Entrez ID: 7095
- UniProt: Q99442
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Required for preprotein translocation. {ECO:0000250}.
Pfam Domains GO Terms
Pfam Domains
| Sec62 |
GO Terms
| posttranslational protein targeting to membrane, translocation |
| posttranslational protein targeting to endoplasmic reticulum membrane |
| intracellular protein transmembrane transport |
| protein transmembrane transport |
| rough endoplasmic reticulum |
| cotranslational protein targeting to membrane |
| integral component of endoplasmic reticulum membrane |
| protein targeting to ER |
| establishment of protein localization to endoplasmic reticulum |
| protein localization to endoplasmic reticulum |
| protein targeting to membrane |
| signaling receptor activity |
| establishment of protein localization to membrane |
| protein targeting |
| establishment of protein localization to organelle |
| protein localization to membrane |
| protein localization to organelle |
| endoplasmic reticulum membrane |
| intracellular protein transport |
| endoplasmic reticulum |
| transmembrane transport |
| protein transport |
| intracellular transport |
| peptide transport |
| amide transport |
| cellular protein localization |
| cellular macromolecule localization |
| establishment of protein localization |
| establishment of localization in cell |
| nitrogen compound transport |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| ALG6 | 0.607 |
| SEC63 | 0.565 |
| DHRSX | 0.556 |
| PMM2 | 0.528 |
| ROMO1 | 0.527 |
| UAP1 | 0.527 |
| MBTPS2 | 0.527 |
| ALG5 | 0.526 |
| ALG9 | 0.524 |
| TRIAP1 | 0.52 |
| SSB | 0.516 |
| MANF | 0.513 |
| UBE2G2 | 0.511 |
| DNAJC3 | 0.507 |
| DNAJB11 | 0.505 |
| ALDH18A1 | 0.505 |
| DPAGT1 | 0.505 |
| DPM1 | 0.503 |
| TRMT10A | 0.501 |
| THG1L | 0.499 |
| ALG8 | 0.499 |
| ALG1 | 0.497 |
| KDSR | 0.497 |
| SRP14 | 0.494 |
| DPM3 | 0.493 |
| UFC1 | 0.492 |
| IRF2BP2 | 0.488 |
| STT3A | 0.487 |
| SRD5A3 | 0.486 |
| UBA5 | 0.485 |
| GTF3C4 | 0.48 |
| ALG13 | 0.479 |
| ATXN10 | 0.478 |
| UBE2J1 | 0.475 |
| ALG3 | 0.472 |
| URM1 | 0.471 |
| TMED10 | 0.466 |
| PGGT1B | 0.466 |
| RPTOR | 0.464 |
| PGM3 | 0.463 |
| RPE | 0.458 |
| TRMT61A | 0.457 |
| KIAA0391 | 0.454 |
| GFPT1 | 0.454 |
| ATG9A | 0.453 |
| CRLS1 | 0.453 |
| C1orf27 | 0.452 |
| MPDU1 | 0.451 |
| CBFB | 0.451 |
| MRPS6 | 0.448 |
| YARS2 | 0.446 |
| DNLZ | 0.446 |
| DOLK | 0.446 |
| GMPPB | 0.445 |
| MBTPS1 | 0.445 |
| TIMM13 | 0.444 |
| PDAP1 | 0.443 |
| ATP5O | 0.442 |
| DOHH | 0.44 |
| EEF1E1 | 0.435 |
| ATP5A1 | 0.433 |
| RFT1 | 0.432 |
| PARS2 | 0.431 |
| RTCB | 0.431 |
| CHCHD4 | 0.428 |
| ENY2 | 0.424 |
| PARL | 0.424 |
| ATP5D | 0.424 |
| ATP2A2 | 0.423 |
| MRPS11 | 0.423 |
| ADSL | 0.422 |
| BCS1L | 0.421 |
| EXOC4 | 0.421 |
| TTC4 | 0.419 |
| TAZ | 0.417 |
| SLC25A26 | 0.416 |
| TIMM8B | 0.414 |
| RPP21 | 0.413 |
| ATP5J | 0.412 |
| TMEM41B | 0.412 |
| ELAC2 | 0.412 |
| RNMT | 0.411 |
| ELP3 | 0.411 |
| SUPV3L1 | 0.41 |
| TSEN54 | 0.409 |
| LSM11 | 0.409 |
| MOCS3 | 0.409 |
| VEZT | 0.407 |
| DAP3 | 0.407 |
| MRPS18A | 0.407 |
| SSBP2 | 0.407 |
| PELO | 0.406 |
| UFSP2 | 0.406 |
| ALG2 | 0.405 |
| ATP5C1 | 0.403 |
| MLST8 | 0.403 |
| TRNT1 | 0.402 |
| PIK3C3 | 0.402 |
| ATP5B | 0.402 |
| GTF3C6 | 0.401 |
| GTF3C3 | 0.401 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 7/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 1/26 |
| breast | 0/33 |
| central nervous system | 1/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 2/75 |
| lymphocyte | 1/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 1/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 3288
- Expression level (log2 read counts): 7.01
Expression Distribution
SEC62 Expression in NALM6 Cells: 7.01
